27 replies to this topic

[nicklesprout]

i found this on reddit and am curious to know if anyone has had any good experiences repairing their brains with BPC-157:

 

https://www.reddit.c...as_a_nootropic/

 

from the link above:

 

BPC-157 reduces tolerance to GABAergics and possibly dopaminergics. The dosage required is much lower than current broscience would indicate.

The case for BPC-157 as a nootropic

BPC-157 is an injectable peptide that doesn't get talked about around here but is well known over at /r/PEDs for it's ability to accelerate the healing of injuries. After having read through the research on pubmed and sampling it myself, I believe it deserves more attention from the Nootropics community.

Virtually all of the studies come from a group in Croatia and they always use the same doses in their mice and rat studies: 10 micrograms per kg and 10 nanograms per kg. Most of the studies find some activity at the lower dose and more activity at the higher dose. This translates to a dosage range of about 1 ng/kg to 1 mcg/kg in humans. The standard advice is to take 200 to 500 mcg for healing purposes when doses of as low as 0.1 mcg could show results.

I've been using doses in the 50-100 mcg range which is on the higher end of the experimental range for the simple reason that if I use doses lower than that the peptide will degrade before I finish it.

I'm not going to get too much into personal experience because you would expect a large placebo reaction to an injectable but it's GABAergic tolerance reducing effects are real for me. There is some evidence that it could do something similar for people who take dopaminergic drugs but I have little experience with these.

Summary of some of the more interesting research

The antidepressant effect of an antiulcer pentadecapeptide BPC 157

• "In a forced swimming test, a reduction of the immobility time in BPC 157 ... treated rats corresponds to the activity of the ... conventional antidepressants, imipramine or nialamide"
• "In chronic unpredictable stress procedure, particular aggravation of experimental conditions markedly affected the conventional antidepressant activity, whereas BPC 157 effectiveness was continuously present."

The effect of a novel pentadecapeptide BPC 157 on development of tolerance and physical dependence following repeated administration of diazepam.

• Reduced diazepam (valium) tolerence
• Reduced withdrawal symptoms
• Had some anticonvulsive effectiveness
• "Theoretically BPC 157 given simultaneously with repeated diazepam could act postsynaptically preventing the downregulation of the benzodiazepines receptors"
• "it could be speculated that BPC 157 acts favoring natural homeostasis of the GABA receptor complex as well as enhancing the GABAergic transmission"

The influence of gastric pentadecapeptide BPC 157 on acute and chronic ethanol administration in mice.

• Reduced intoxication, prevented overdose death
• Reduced withdrawal symptoms
• Protected against stomach and liver lesions

BPC 157 attenuates disturbances induced by neuroleptics

• "it blocks the stereotypy produced acutely by amphetamine in rats"
• "these findings indicate that pentadecapeptide BPC 157 fully interacts with the dopamine system, both centrally and peripherally, or at least, that BPC 157 interferes with some steps involved in catalepsy and/or ulcer formation"

Pentadecapeptide BPC 157 attenuates chronic amphetamine-induced behavior disturbances.

• "BPC 157 has a modulatory effect on dopamine system, and it could be used in chronic amphetamine disturbances"

BPC 157 effective against serotonin syndrome (2005)

• "in severe serotonin syndrome, gastric pentadecapeptide BPC 157 ... has a beneficial activity, which is likely, particular, and mostly related to a rather specific counteraction of 5-HT2A receptors phenomena"
• The down-regulation effect on the 5-HT2A receptor is interesting. From wikipedia: "findings suggest that post-synaptic 5-HT2A overdensity is involved in the pathogenesis of depression"

European Patent 0983300 A1

• Good summary of the many potential uses of BPC-157. Contains some (not properly cited) references to studies I can't find on pubmed.
• EXAMPLE 35: The Effect on Convulsions
  • "KBPC157 produced a consistently positive (dose and time dependent) anti-convulsive effect against all of the applied convulsants"
• EXAMPLE 48: Effect on Cognitive Disorders
  • "application of anti-cholinergic agents (scopolamine, atropine) led to a significant cognitive deficit in the rats"
  • "This cognitive deficit was abolished ... by subsequent coadministration of NaBPCI 57"
  • "Considering the widely implicated significance of these models for human cognitive function impairments, it is evident that NaBPCI 57 is useful in the therapy of cognitive disorders"

[Ark]

Good post, oddly enough there hasn't been much discussion on this substance. I'll do a little digging myself to see what information is out there.

[Madman]

Ive been using this substance for exactly this reason and also overall tissue/intestinal repair for 2 months using a nasal spray

 

Right now I'd say its effective, still early to give full results.

 

My mental functioning, mood and balance is much improved but I'm taking a lot of other things so its hard to be sure at the moment how much its contributing, Ill update after I cycle it again.

[nicklesprout]

Ive been using this substance for exactly this reason and also overall tissue/intestinal repair for 2 months using a nasal spray

Right now I'd say its effective, still early to give full results.

My mental functioning, mood and balance is much improved but I'm taking a lot of other things so its hard to be sure at the moment how much its contributing, Ill update after I cycle it again.

What is your daily dose? What were you trying to fix mentally wise?

[Madman]

The last few years Ive been suffering from very low brain performance due to some things I won't discuss here which have caused considerable damage to brain, my functioning in mood disturbances, stress response, ability to do lots of simple tasks, complex reasoning, thinking abilities, social interaction, learning, reading, and others.

 

Before I started to tackle this brain functioning issue, my level of improvement over the last year or two has been minimal in comparison.

 

Ive used a dosage of 5-10mg a week in divided doses throughout the day, roughly 1-2 mg per day in total, administered in a nasal spray.

 

However, the biggest improvement in terms of brain repair/functioning I noticed was from the use of GH and IGF1 which I did not expect to occur but on looking at the research they both show a connection in this area. Since using GH and IGF1 ive seen rapid improvement in all areas of brain functioning, with the exception of slight lethargy caused by the GH release. I'm of course not condoning nor recommending the use of either but it seems they work very well in this area but have obvious potential side effects, although I have experienced none at the dosages Ive taken except for mild GH lethargy.

 

Right now I'm probably at 80% of previous functioning performance and still improving, I'm hoping I'll see an improvement over previous functioning when I reach 100%

 

Ive also used TB500 although I'm not sure if this impacts on brain repair.

Edited by Madman, 18 January 2017 - 11:35 AM.

[Madman]

Forgot to mention, I'm not using synthetic GH (Too many side effects) but peptides Mod GRF-1-29 with Ipamorellin (Virtually side effect free except for a tiny amount of lethargy which is a good thing for me) which stimulates my body to release its own GH multiple times per day.

 

Not recommending anyone do the same as me, just providing this for information purposes.

Edited by Madman, 18 January 2017 - 08:25 PM.

[Autumn Knight]

Forgot to mention, I'm not using synthetic GH (Too many side effects) but peptides Mod GRF-1-29 with Ipamorellin (Virtually side effect free except for a tiny amount of lethargy which is a good thing for me) which stimulates my body to release its own GH multiple times per day.

 

Not recommending anyone do the same as me, just providing this for information purposes.

 

Where do you get your Ipamorelin and GRF-1-29, and how do you administer them?

[Madman]

I take 100mcg each of both Ipamorelin and GRF-1-29 , 5 times per day SUBQ with an insulin syringe-needle, this can be done at 3 times per day for life extension purposes but the overall daily GH output is best with 5 or more pulses.

 

Won't post a supplier on this thread, but if you PM me I'll be happy to tell you where I buy them from. There are many peptide suppliers on the internet now.

[tolerant]

Dear Topic Starter,

 

What dose did you use/are you using to effect benzodiazepine tolerance reduction. How do you notice the reduction? Do you get the effect of the benzodiazepines back or is it preventing withdrawal symptoms from tapering?

 

Thanks,

 

tolerant

[nicklesprout]

this substance did not help me.  i dosed according to the Ben Greenfield Fitness blog post:

 

https://bengreenfiel...to-use-bpc-157/

 

i took it for a whole month, either injected into the glutes or else sprayed orally into my mouth.  noticed maybe a slight calming effect every now and again, or could have been placebo. other than that, it was a waste of money for me. i don't think it's the miracle drug for everyone.  

 

i can't say my problems are all benzo related, but i believe that is a big part of it.  the adolescent MJ usage probably didn't help either.  

 

that's really all i can say, it may help you though.

[Icarus7]

I had adverse affect.  Was using it to treat mTBI. It could be that i stopped before giving it full trial as I developed rash ,sore throat, and anxiety.  I rarely get panic attacks and have been dealing with insane symptoms for 7 years.  The rash I am 100% is related to BPC though I'm not sure about sore throat as virus was going around house.  

 

Now I'm getting brain zaps.  My theory is it's related to BPC affect on serotonin.  

 

From a study cited on examine.com

 

In the first series of experiments, a single dose treatment of BPC157 (10 microg/kg) administered intraperitoneally 40 min before the alpha-MTrp tracer injection significantly reduced the regional rate of 5-HT synthesis in the dorsal thalamus, hippocampus, lateral geniculate body and hypothalamus. 5-HT synthesis rates in the substantia nigra reticulate and medial anterior olfactory nucleus in BPC157 treated rats were significantly higher than in the control rats. No significant change in the synthesis rate was observed in the raphe nuclei. In the second series of experiments, following a 7-day treatment with BPC157 (10 microg/kg; s.c.), a significant reduction in the 5-HT synthesis rate was observed in the dorsal raphe nucleus, and significant increases were observed in the substantia nigra, lateral caudate, accumbens nucleus and superior olive. This data suggests that BPC157, a gut peptide, influences brain 5-HT synthesis in rats, but we cannot determine, from this data, the mechanism of this action.

 

Brain zaps seem to be common side effect of those that withdrawal from anti-depressants.  I've never taking SSRI long term, as both my trials with those failed after 1 month and never have had this symptom before.  If I was certain that the sore throat wasn't bpc related, I maybe would give it another trial.  Anxiety is definitely heightened now and sleep is affected so will likely wait a couple weeks to see if I return to my baseline.  

[John250]

Wow I used to use bpc on my shoulder when it would act up after heavy training. It healed within days of using 250mcg IM in the tendon effected. I’m very interested in it’s positive effects on dopamine from amphetamine use. I’ll probably order some and just use 200mcg SubQ as it wouldn’t need to be localized.

[John250]

More great info on bpc. I’ll be using it at 1mcg/kg so only 110mcg/day

Potassium Imbalance: BPC 157 gives protection from the heart failure in the state of both hyperkalemia that is potassium overdose and hypokalemia, which is potassium overdose.
Blood Pressure: The BPC 157 is seen to increase the blood pressure with lower blood pressure and decrease the blood pressure with high blood pressure.
Calcium Imbalance: it gives protection from damage caused due to hypercalcemia. It also protects from the overdose of the calcium channel broker. Magnesium overdose: the BPC 157 gives protection from magnesium overdose or hypermagnesemia.
Toxicity and side effects of NSAIDs: The BPC 157 effectively reduces the NSAIDs’ adverse effects & toxicity such as prolonged bleeding, level, intestinal, brain lesions and various other behavioral disturbances. All these side effects are effectively antagonized by the administration of BPC 157.
Alcohol intoxication: The BPC 157 is also shown to have displayed prevention and inhibition of the harmful effects of acute intoxication from alcohol, and liver and gastric lesions.
Gastric ulcers: The product not only just prevents but also heals gastric ulcers. The BPC 157 helps in reducing the area of the ulcer and speeding up the reconstruction of the glandular epithelium & granulation tissue formation.
Inflammation, body temperature, and pain: The supplement effectively reduces various models of non-specific and acute inflammation. It increases the pain threshold and acts against the decrease (that is, a test of water immersion) & increase (yeast-induced) in temperature.
Diabetes: It increases the healing of the skin wounds, prevents the fructose-induced high BP. It also inhibits the development of the insulin resistance.
Dopamine system: BPC 157 significantly reduces the motor abnormalities & hyperactivity, which is induced by dopaminergic neurotoxin MPTP. It also decreases the behavioral disturbances that are basically chronic amphetamine-induced.
Wound Healing: The BPC 157 improves healing significantly after injuries such as deep skin burns, skin incisions, diabetic wounds, different anastomoses like intestinal wounds, different tissue transactions, various fistulas, particularly tendon, ligament, nerve, and muscle. The time taken to heal from all the said injuries is decreased significantly with the administration of BPC 157.

[John250]

Would be BPC 157 reduce the positive effects of amphetamines? Was a bit confused by the study.

[Icarus7]

Would be BPC 157 reduce the positive effects of amphetamines? Was a bit confused by the study.

[Icarus7]

Yes, that has been noted in several people over on Reddit. For some the positive effects they used to get from amphetmaines returned after month but others never came back and would get side effects.

For myself, even stimulant like coffee gave me negative effects while I was doing bpc and up to 1 week after. Of course, my neurotransmitters are going to be completely different having a mTBI.

[Omega 3 Snake Oil]

Wound Healing: The BPC 157 improves healing significantly after injuries such as deep skin burns, skin incisions, diabetic wounds, different anastomoses like intestinal wounds, different tissue transactions, various fistulas, particularly tendon, ligament, nerve, and muscle. The time taken to heal from all the said injuries is decreased significantly with the administration of BPC 157.

Can you inject it directly into scars (scars that happened internally, ie lesions) using the sub-q needles? I'm assuming so. 

Also, can you spray in the mouth for neurological healing?

[John250]

Can you inject it directly into scars (scars that happened internally, ie lesions) using the sub-q needles? I'm assuming so.

Also, can you spray in the mouth for neurological healing?

Never tried either of those methods

[Omega 3 Snake Oil]

I had adverse affect.  Was using it to treat mTBI. It could be that i stopped before giving it full trial as I developed rash ,sore throat, and anxiety.  I rarely get panic attacks and have been dealing with insane symptoms for 7 years.  The rash I am 100% is related to BPC though I'm not sure about sore throat as virus was going around house.  

 

Now I'm getting brain zaps.  My theory is it's related to BPC affect on serotonin.  

 

From a study cited on examine.com

 

In the first series of experiments, a single dose treatment of BPC157 (10 microg/kg) administered intraperitoneally 40 min before the alpha-MTrp tracer injection significantly reduced the regional rate of 5-HT synthesis in the dorsal thalamus, hippocampus, lateral geniculate body and hypothalamus. 5-HT synthesis rates in the substantia nigra reticulate and medial anterior olfactory nucleus in BPC157 treated rats were significantly higher than in the control rats. No significant change in the synthesis rate was observed in the raphe nuclei. In the second series of experiments, following a 7-day treatment with BPC157 (10 microg/kg; s.c.), a significant reduction in the 5-HT synthesis rate was observed in the dorsal raphe nucleus, and significant increases were observed in the substantia nigra, lateral caudate, accumbens nucleus and superior olive. This data suggests that BPC157, a gut peptide, influences brain 5-HT synthesis in rats, but we cannot determine, from this data, the mechanism of this action.

 

Brain zaps seem to be common side effect of those that withdrawal from anti-depressants.  I've never taking SSRI long term, as both my trials with those failed after 1 month and never have had this symptom before.  If I was certain that the sore throat wasn't bpc related, I maybe would give it another trial.  Anxiety is definitely heightened now and sleep is affected so will likely wait a couple weeks to see if I return to my baseline.  

I just got some BPC but havent tried it yet. This worries me a lot. I get a lot of brain zaps and have what I'm sure is degenerative damage to my hypothalamus. I also take selegiline, 1.25mg a day. An earlier post shows BPC actually protects against serotonin syndrome. 

Icarus. any updates, did you try BPC again? I'm wondering if I should just try a tiny dose, like 80-100mcg to see if there's an adverse reaction.

[Mind_Paralysis]

Can you inject it directly into scars (scars that happened internally, ie lesions) using the sub-q needles? I'm assuming so. 

Also, can you spray in the mouth for neurological healing?

 

Wouldn't it make more sense to spray into your NOSE if  your going to heal damage to the CENTRAL nervous system? Ak a the brain. I suppose spinal injections might do the trick too.

 

Another option is of course DMSO, but then you supposedly get it everywhere in your body, so that would kind of take away the point of concentrating the effects...

[Omega 3 Snake Oil]

Wouldn't it make more sense to spray into your NOSE if  your going to heal damage to the CENTRAL nervous system? Ak a the brain. I suppose spinal injections might do the trick too.

 

Another option is of course DMSO, but then you supposedly get it everywhere in your body, so that would kind of take away the point of concentrating the effects...

That makes sense. Does anyone have instructions for preparing BPC for intranasal use? I'd be worried about getting the dosing right when spraying it. 

DMSO seems to make my neuromuscular symptoms worse. I've heard it chelates copper.

[Mind_Paralysis]

That makes sense. Does anyone have instructions for preparing BPC for intranasal use? I'd be worried about getting the dosing right when spraying it. 

DMSO seems to make my neuromuscular symptoms worse. I've heard it chelates copper.

 

Well, you could always increase your intake of other bioavailable mineral-chelations prior to starting DMSO again - look into the copper detoxification-protocols floating around out there - if I recall correctly, you just need to add enough other metals to displace the copper.

[VanWinkle]

I found this discussion because I too am interested in brain and reair. I have had MS for 25 years, the last 8 of which I have been in a wheelchair. I have damage to the white and grey matter of the brain and spinal cord from MS lesions, and demyelination of axons. 

 

What you are discussing on the bain repair ability of BPC-157 sounds promising, and is supported by animal research.

 

2013 Stable anti-ulcer gastric pentadecapeptide BPC 157 also for multiple sclerosis: Counteraction of cuprizone brain injuries and motor disability (in rats)

 

Consistently less nerve damage was in all damaged areas in all BPC 157-cuprizone rats, also in those areas that were most affected. Consistently, BPC 157 counteracts cerebellar ataxia, rescues impaired forelimb function. Thereby, we advocate BPC 157 also in MS therapy. 

-----------

This one was just published, again from the  researchers in Croatia.

 

J Orthop Surg Res. 2019 Jul 2;14(1):199. doi: 10.1186/s13018-019-1242-6.

Stable gastric pentadecapeptide BPC 157 can improve the healing course of spinal cord injury and lead to functional recovery in rats (full paper)

 

Abstract

BACKGROUND:

We focused on the therapeutic effects of the stable gastric pentadecapeptide BPC 157 in spinal cord injury using a rat model. BPC 157, of which the LD1 has not been achieved, has been implemented as an anti-ulcer peptide in inflammatory bowel disease trials and recently in a multiple sclerosis trial. In animals, BPC 157 has an anti-inflammatory effect and therapeutic effects in functional recovery and the rescue of somatosensory neurons in the sciatic nerve after transection, upon brain injury after concussive trauma, and in severe encephalopathies. Additionally, BPC 157 affects various molecular pathways.

 

METHODS:

Therefore, BPC 157 therapy was administered by a one-time intraperitoneal injection (BPC 157 (200 or 2 μg/kg) or 0.9% NaCl (5 ml/kg)) 10 min after injury. The injury procedure involved laminectomy (level L2-L3) and a 60-s compression (neurosurgical piston (60-66 g) of the exposed dural sac of the sacrocaudal spinal cord). Assessments were performed at 1, 4, 7, 15, 30, 90, 180, and 360 days after injury.

 

RESULTS:

All of the injured rats that received BPC 157 exhibited consistent clinical improvement, increasingly better motor function of the tail, no autotomy, and resolved spasticity by day 15. BPC 157 application largely counteracted changes at the microscopic level, including the formation of vacuoles and the loss of axons in the white matter, the formation of edema and the loss of motoneurons in the gray matter, and a decreased number of large myelinated axons in the rat caudal nerve from day 7. EMG recordings showed a markedly lower motor unit potential in the tail muscle.

 

CONCLUSION:

Axonal and neuronal necrosis, demyelination, and cyst formation were counteracted. The functional rescue provided by BPC 157 after spinal cord injury implies that BPC 157 therapy can impact all stages of the secondary injury phase.

----------------------------------

 

[mati5000]

Hello,

 

I also tested this substance called bpc-157 after use baclofen. my mind is brighter younger. I don't care if something goes wrong anymore, this may be due to the reaction to GABA. the action  of bpc-157 was already noticeable after two days.

 

I use the caps version (Stable form)

 

Thanks

[Daniel Cooper]

Hello,

 

I also tested this substance called bpc-157 after use baclofen. my mind is brighter younger. I don't care if something goes wrong anymore, this may be due to the reaction to GABA. the action  of bpc-157 was already noticeable after two days.

 

I use the caps version (Stable form)

 

Thanks

 

Thanks for the info.

 

Where did you buy from?

[mati5000]

Thanks for reply

 

I bought from this site: https://salsuranutri...table-form.html

 

I take this caps twice a day. (250mcg) in one capsule.

 

 

[userCK]

OP/others:

are you saying BPC-157 also up-regulates Dopamine receptors. particularly d2?

Edited by userCK, 11 September 2020 - 12:17 AM.

[effinrich]

I used BPC-157 for the purpose of dopamine receptor repair.  It worked in resetting my tolerance to more things than dopaminergic drugs/supplements, which was interesting.  I abstained from my adderall for the month I trialed it.  Upon cessation of BPC, my adderall was back to working as it should with one difference.  The edgy physical feeling of the adderall come-up was gone, which I never considered bad, but often used the feeling as an indicator of it "working".  Even with higher doses when up late knocking out a deadline didn't result in that high-ish feeling, just more of the adderall cognitive effects.  Frankly I wasn't super jazzed about that because I enjoyed that side effect to some degree.  However I felt it was worth it to get back to productivity.  

 

A very unexpected result was the BPC killed my tolerance to microdosing to a point I don't ever recall existing.  I had been taking .3-.5 grams of mushrooms 2 days a week for 2 or more years.  I always used the same vendor and at this point had the same batch I had prior to starting BPC-157.  When I microdosed after my month trial it knocked me on my ass, like couldn't drive to work level of tripping.  That was from .25 grams.  I thought it was some very weird interaction and mushrooms have NEVER had that profound an effect for me, they've always been very controllable and nice at low doses.  So, with that in mind, I tried even less a few days later at .20 grams.  Again, so high it was uncomfortable.  After that I determined the BPC had reset that tolerance as well as dopaminergics, caffeine, etc.  Eventually, a year after I think, I went back to microdosing and it was much more tolerable albeit still stronger than normal.