I ran into this on another forum, fascinating stuff, especially considering titanium in sunscreens likely gets into the hairline.
From: http://www.hairlossh...=y&STARTPAGE=84
"Originally posted by: eldarlmario
So we take Dr Cotsarelis's findings:
ALL genes UPREGULATED in haired-scalp when compared to bald scalp as indicated in Dr Cotsarelis's patent- with reference from ctdbase.org(from most to least- bold for beneficial for the hair, underlined for non-beneficial for the hair):
GPRC5D: Tretinoin=UP(from the GPRC5D study with all trans retinoid acid), Zinc=DOWN, Dibutyl Phthalate=UP
CDT6(aka ANGPTL7): Valproic acid=UP, Tretinoin=DOWN, 2,2',4,4'-tetrabromodiphenyl ether=UP
LY6G6D: Valproic acid=AFFECTED, Fullerene C60=DOWN, Titanium dioxide=UP
S100A3: Calcitriol=UP, Valproic acid=UP, Titanium dioxide=DOWN, Lithium Chloride=UP
COMP: Valproic acid=UP, Titanium Dioxide=UP, Zinc=DOWN,
PSORS1C2: 2,2',4,4'-tetrabromodiphenyl ether=UP
DAZ2: 8-Bromo cAMP=UP
DAZ4: ?
GPR49(aka LGR5): Pirinixic acid=DOWN, Resveratrol=DOWN, Valproic acid=UP
Hypothetical protein MGC4504(aka CHAC1): Phenobarbital=DOWN, 2,2',4,4'-tetrabromodiphenyl ether=UP, Copper=UP, Dibutyl Phthalate=UP, Zinc=UP, Titanium dioixde=DOWN, Silicon dioxide=UP, Pirinixic acid=UP, Valproic acid=DOWN
FGF18(via FoxP1): Tretinoin=UP, Valproic acid=UP
DAZ3: ?
K6HF(aka KRT75): Copper sulfate=UP, Pirinixic acid=UP, Tretinoin=DOWN
SERPINA1: Caffeine=UP, Copper=DOWN, Phenobarbital=UP, Dibutyl Phthalate=UP, Flutamide=DOWN(AR blockers), Fullerene C60=UP, Genistein=UP, Omeprazole=AFFECTED, Pirinixic acid=DOWN, Resveratrol=UP, Valproic acid=DOWN
DKFZP565A1524(aka FAM49A): Valproic acid=UP, Butyraehdye=UP, Calcitriol=UP, Tretinoin=DOWN, Zinc=DOWN
LRRC15: Valproic acid=UP, Genistein=UP, Fullerene C60=DOWN
dkfzp564O0823(aka PARM1): Valproic acid=UP, Copper=UP, Dibutyl Phthalate=UP, Zinc=DOWN
SLC27A6: Pirinixic acid=UP, Tretinoin=DOWN, Valproic acid=UP
PPP2R1B: Valproic acid=UP, Vitamin E=DOWN, Tretinoin=DOWN, Pirinixic acid=UP, Fullerene C60=DOWN, Flutamide(assuming other AR blockers as well)=DOWN, Copper sulfate=DOWN
EHD3: Zinc=UP, Valproic acid=UP, Pirinixic acid=DOWN, Fullerene C60=UP, Halofuginone=UP
BAMBI: Copper=UP, Pirinixic acid=DOWN, Valproic acid=UP, Tretinoin=AFFECTED
BNC2: Valproic acid=UP, Tretinoin=UP
PDZRN3: Pirinixic acid=UP, Tretinoin=UP, 8-bromo cAMP=DOWN, Valproic acid=UP
CHST2: Valproic acid=UP, Fullerene C60=UP
BMP2: Tretinoin=UP, Resveratrol=UP, Calcitriol=UP, Fullerene C60=DOWN, Genistein=UP, Pirinixic acid=DOWN, Valproic acid=DOWN, PGE2(via the EP4 Receptor)=UP
SERPINA3: Prozac=UP, Ketoconazole=UP, Copper sulfate=DOWN, Curcumin=DOWN, Calcitirol=UP, Tretinoin=UP
LHX2: Zinc=DOWN, Valproic acid=DOWN, Tretinoin=DOWN, Resveratrol=UP, Copper sulfate=UP, Carbamazepine=Affected
SLC7A8: Valproic acid=UP, Calcitriol=DOWN, Pirinixic acid=DOWN
THBS1: Genistein=UP, Curcumin=DOWN, Dopamine=UP, Pirinixic acid=UP, Resveratrol=Affected, Tretinoin=Affected, Valproic acid=UP, Copper=UP
DNAJC8: Valproic aicd=UP, Pirinixic acid=DOWN
MYCN: Tretinoin=DOWN, Valproic acid=UP, Resveratrol=DOWN, Copper=UP, Phenobarbital=DOWN, Panthothenic acid(aka Vitamin B5)=UP
SLN: Zinc=DOWN, Titianium dioxide=DOWN, Pirinixic acid=Affected, Fullerene C60=Affected, Trichostatin A(presumably Valproic acid as well)=UP
FLRT3: Calcitriol=UP, Prinixic acid=UP, Titanium dioxide=Affected, Tretinoin=UP, Valproic acid=Affected, Vitamin E=DOWN
HOXC13(This gene is at the centre of multiple crossroads in regards to hair stem cell activation): Valproic acid=UP
SLC7A11: Valproic acid=UP, Curcumin=UP, Copper sulfate=UP, Tretinoin=DOWN, 8-Bromo cAMP=DOWN, Bicalutamide(assuming for other AR blockers as well)=UP, Copper=UP, Prozac=UP, Genistein=DOWN, Sulfasalazine=DOWN, Zinc=UP
AF1Q: Pirinixic acid=UP, Tretinoin=UP, Copper=UP, Valproic acid=DOWN, Lithium Chloride=DOWN
NR4A2: Pirinixic acid=UP, Valproic acid=UP, 8-Bromo cAMP=UP, Copper sulfate=UP, Curcumin=DOWN, Prozac=DOWN, Lithium Chloride=UP, PGE2=UP, Titanium Dioxide=UP, Zinc=UP
MEST: Copper sulfate=UP, Pirinixic acid=UP, Valproic acid=DOWN, Titanium Dioxide=UP
TMSSF1: Calcitriol=DOWN, Pirinixic acid=UP, Lithium Chloride=UP, Valproic acid=AFFECTED
CRLF1: Valproic acid=UP, Tretinoin=UP, Fullerene C60=UP
CDC42EP3: Tretinoin=DOWN, Calcitriol=UP, Pirinixic acid=UP, Valproic acid=DOWN
FABP4(By examing the chemicals that upregulate/downregulate it- it is easy to tell that this gene has got something to do with adipogenesis): Pirinixic acid=UP, PGJ2=UP, Resveratrol=DOWN, Valproic acid=UP, Calcitriol=DOWN, Ethanol=DOWN, Caffeine=DOWN, Bicalutamide=UP(and presumably any AR Blockers), Capsaicin=DOWN, PGD2=UP, Tretinoin=UP, Zinc=DOWN
MSX2: Valproic acid=UP, Tretinoin=UP, Calcitriol=UP
S100P: Bicaluatamide=UP(and presumbably other AR blockers), Copper=UP, Calcitriol=UP, Resveratrol=UP, Zinc=UP, Tretinoin=UP
SDC2: Copper=UP, Pirinixic acid=DOWN, Ascrobic acid=DOWN, Nitric Oxide=DOWN, Tretinoin=DOWN, Trichostatin A=DOWN(presumably Valproic acid as well), Vitamin E=UP, Resveratrol=UP, Glucosamine=DOWN
BASP1: Valproic acid=UP, Tretinoin=DOWN, Genistein=DOWN, Fullerene C60=DOWN, Copper sulfate=UP
KAL1: butyraldehyde=UP, Valproic acid=UP
TNFRSF12A: Croton Oil=UP, Calcitriol=UP, Genistein=DOWN, Valproic acid=UP
CDC42EP3: Tretinoin=DOWN, Calcitriol=UP, Pirinixic acid=UP, Dibutyl Phthalate=UP, Valproic acid=DOWN
ABCA4: Copper sulfate=UP, Pirinixic acid=UP
CYFIP2: Valproic acid=UP, Pirinixic acid=UP, Tretinoin acid=UP
KIAA0992(aka PALLD): Valproic acid=UP, Tretinoin=UP, Calcitriol=DOWN, Copper=UP, Pirinixic acid=AFFECTED
UNC5B: Pirinixic acid=UP, 8-Bromo cAMP=DOWN, Copper sulfate=UP, Butyraldehyde=UP, Valproic acid=UP, Titanium Dioxide=UP
TIMP3: Valproic acid=UP, Genistein=DOWN, Dibutyl Phthalate=UP, Capsaicin=UP, Copper sulfate=DOWN, Calcitriol=DOWN, Glucosamine=UP, Pirinixic acid=UP, Phthalic acids=UP, Resveratrol=DOWN, Tretinoin=UP, Vitamin E=UP, Zinc=UP, Curcumin=DOWN
GPR34: Iron=DOWN
MSX1: Valproic acid=UP. Tretinoin=UP, Copper sulfate=UP
Selenbp1(examing the chemical agents that upregulate/downregulate this gene- it seems that androgenic agents upregulates it. e.g DHT): Dibutyl Phalate=DOWN, DHT=UP, Flutamide=DOWN(presumably other AR blockers), Genistein=DOWN, Fullerene C60=UP, Glucosamine=DOWN, Valproic acid=DOWN, Zinc=DOWN, Tretinoin=UP
PAMCI(aka RASSF9): Pirinixic acid=UP, Trichostatin A=UP(valproic acid as well), Titanium Dioxide=DOWN, Butyraldehyde=DOWN
CTSL2: Valproic acid=UP, Butyraldehyde=UP
CREB5: Copper sulfate=UP, Flutamide=UP(AR blockers), Valproic acid=UP, Titanium Dioxide=UP, Tretinoin=AFFECTED
VSNL1: Valproic acid=dose-dependent, Tretinoin=DOWN, Halofuginone=DOWN, Calcitriol=DOWN, Dibutyl Phthalate=UP, Phthalic acid=DOWN, Titanium Dioxide=DOWN
S100A2: Copper=DOWN, Valproic acid=UP, Zinc=Affected
UBE2H: Valproic acid=UP, Copper sulfate=UP, Pirinixic acid=UP, Titanium dioxide=UP, Tretinoin=UP
PKP1: Pirinixic acid=UP, Fullerene C60=DOWN, Butyraldhyde=UP
SLCO3A1: Valproic acid=UP, Dibutyl Phthalate=UP, Phthalic acid=DOWN, Tretinoin=DOWN
PPP1R2: Valporic acid=UP, Butyraldhyde=UP, Flutamide=UP(AR blockers), Resveratrol=UP
B7-H4(aka VTCN1): Valproic acid=UP, Tretinoin=UP, Pirinixic acid=Down
SDC1: Pirinixic acid=AFFECTED, Tretinoin=DOWN, Copper=UP, Miconazole=DOWN,
ELOVL6: Pirinixic acid=UP, Butyraldehyde=DOWN, Copper=DOWN, Dibutyl Phthalate=DOWN, Omega-6=UP, Glucosamine=UP, Phthalic acid=DOWN, Tretinoin=DOWN, Valproic acid=UP
STK17A: Valproic acid=UP, Resveratrol=UP
DACH1: Valproic acid=UP, Tretinoin=UP, Titanium DIoxide=AFFECTED
SOX9: Tretinoin=DOWN, Dibutyl Phthalate=DOWN, Pirinixic acid=UP, Valproic acid=UP, Resveratrol=UP, Copper sulafate=DOWN, Curcumin=UP, Calcitriol=UP, Vitamin E=DOWN, Niacinamide=DOWN
SPOCK: ?
PTP4A1: Pirinixic acid=UP, Dibutyl Phthalate=DOWN, Valproic acid-AFFECTED, Butyrates=DOWN, Copper sulfate=DOWN, Calcitriol=UP, Fullerene C60=DOWN, Phenobarbital=UP, Silicon dioxide=UP, Vitamin E=DOWN, 8-bromo cAMP=UP
TUBB: Valproic acid=DOWN, Genistein=DOWN, Pirinixic acid=DOWN, Titianium dioxide=UP, Vitamin E=UP
PCOLCE2: Titanium Dioxide=DOWN, Tretinoin=DOWN, Valproic acid=UP, 2,2',4,4'-tetrabromodiphenyl ether=UP, Copper sulfate=DOWN, Silicon dixoide=DOWN, Halofuginone=UP
CYP1B1: Valproic acid=UP, Genistein=DOWN, Resveratrol=DOWN, Omeprazole=UP, Tretinoin=UP, Ethanol=UP, Ketoconazole=DOWN, Biotin=UP, Copper sulfate=UP, cAMP=UP, Titanium Dioxoide=DOWN
ADAMTS1: Valproic acid=UP, Dibutyl Phthalate=UP, DHT=UP, Pirinixic acid=UP
ACTN1: Dibutyl Phalate=UP, Copper sulfate=UP, Valproic acid=UP
LTBP2: Copper=UP, Dibutyl Phthalate=AFFECTED, Calcitriol=UP, Zinc=DOWN
PCDH7: Valproic acid=UP, Tretinoin=UP, Titanium Dioxide=AFFECTED
NFIL3: Dibutyl Phthalate=UP, Pirinixic acid=UP, Fullerene C60=DOWN, Valproic acid=UP
GPR161: Valproic acid=UP
HEPH(this gene has got something to do with intracellular Iron metabolism): Valproic acid=DOWN, Copper=UP, Zinc=UP, Titanium Dioxide=DOWN
FZD7: Butyraldehyde=DOWN, Pirinixic acid=UP, Tretinoin=AFFECTED, Trichostatin A=UP(presumbably Valproic acid as well)
CLIC4: Valporic acid=UP, Zinc=DOWN, Copper=UP, Butyraldehyde=UP
ID3: Tretinoin=UP, Pirinixic acid=DOWN, Titanium Dioxide=DOWN, Valproic acid=DOWN, Zinc=AFFECTED, Lithium CHloride=DOWN, Caffeine=UP, Copper sulfate=UP, Glucosamine=UP, Lithium chloride=DOWN, PGF2A=DOWN
ALL genes DOWNREGULATED in haired-scalp when compared to bald scalp(from least to most- bold for beneficial for the hair, underlined for non-beneficial for the hair). By downregulating the genes below here- we basically fulfill the other half of the 'cure':
OMD: Dopamine=DOWN, Ethanol=DOWN, Orphenadrine(a common muslce relaxant)=DOWN, Pirinixic acid=DOWN, Titanium Dioxide=DOWN, Silicon Dioxoide=UP, Valproic acid=DOWN
IGF1: Fullerene C60=DOWN, Capsaicin=UP, Pirinixic acid=DOWN, Zinc=AFFECTED, Resveratrol=AFFECTED, Valproic acid=UP, Ethanol=UP
IRF1: Clofibric acid=DOWN, Phenobarbital=DOWN, Mangiferin=DOWN, Thioctic(aka alpha lipoic acid)=DOWN, Tretinoin=UP, Pirinixic acid=DOWN, Valproic acid=UP, Calcitriol=DOWN, Flutamide(AR blockers)=DOWN, Glucosamine=DOWN
OLFML3: Phenobarbital=DOWN, Oxyquinoline=DOWN, Valproic acid=UP, Genistein=UP, Resveratrol=UP, Tretinoin=UP, Vitamin E=UP, Silicon Dioxide=DOWN
IGKC: Ketoconazole=DOWN, Phenobarbital=DOWN,
GPR105(aka P2RY14): Phenobarbital=AFFECTED, Pirinixic acid=AFFECTED, Phthalic acid=DOWN, Tretinoin=UP
NMU: Valproic acid=UP, Butyradehyde=UP, Copper=UP, Calcitriol=DOWN, Pirinixic acid=UP, Resveratrol=UP, Tretinoin=UP
PCSK2: Copper sulfate=DOWN
MOXD1: PPAR Alpha=DOWN, Valproic acid=UP, Butyraldhyde=UP, Pirinixic acid=DOWN, Tretinoin=UP, Vitamin E=UP, Zinc=DOWN
PTPRC: Pirinixic acid=DOWN, Genistein=UP, Titanium Dioxide=UP, Tretinoin=UP
CTSK: Titanium Dioxoide=UP, Zinc sulfate=DOWN, Ascorbic acid=UP, Ethanol=UP, Fullerene C60=UP, Genistein=DOWN, Silicon dioxide=UP, Tretinoin=AFFECTED, Valproic acid=DOWN, Calcitriol=DOWN, Zinc=UP
TRIM22: Valproic acid=DOWN, Butyraldehyde=DOWN, Copper sulfate=DOWN, Tretinoin=DOWN
RUNX3: Phthalic acid=AFFECTED, Tretinoin=DOWN, Valproic acid=AFFECTED
DSCR1L1(aka RCAN2): Pirinixic acid=UP, Titanium Dioxide=UP, Tretinoin=UP, Valproic acid=UP, 2,2',4,4'-tetrabromodiphenyl ether=DOWN
OSR2: 2,2',4,4'-tetrabromodiphenyl ether=DOWN, Calcitriol=UP, Butyraldhyde=UP, Copper=DOWN, Copper sulfate=DOWN, Dibutyl Phthalate=DOWN, Phthalic acid=DOWN, Vitamin E=UP
PDGFRL: Valproic acid=UP, Tretinoin=DOWN, 2,2',4,4'-tetrabromodiphenyl ether=DOWN, Copper sulfate=DOWN, Dibutyl Phthalate=UP, Lithium CHloride=UP, Pirinixic acid=UP, Titanium Dioxide=DOWN
PLA2G2A: Valproic acid=UP, Curcumin=DOWN, DMSO=DOWN, Fullerene C60=UP, Genistein=DOWN, Acetovanillone=DOWN, PGE2=UP, Pirinixic acid=UP, Tretinoin=UP, Resveratrol=DOWN
CXCL9: Silicon Dioxide=UP, Titanium Dioxide=UP, Pirinixic acid=DOWN, Flutamide(AR blockers)=UP, Resveratrol=DOWN, Tretinoin=UP, Luteolin=DOWN
PSMB9: Pirinixc acid=DOWN, Valproic acid=UP, Tretinoin=UP, Fullerene C60=DOWN, Lithium Chloride=UP, Salicylic acid=UP, Titanium Dioxide=UP, Vitamin E=UP
BCHE: Valproic acid=Dose-dependent, Pirinixic acid=UP, Calcitriol=DOWN, Genistein=UP, Resveratrol=UP
DPT: Pirinixic acid=DOWN, Titanium dioxide=DOWN, Tretinoin=DOWN, Vitamin E=UP
ADRA2A: Pirinxic acid=UP, Valproic acid=UP, Fullerene C60=DOWN, Tretinoin=UP, Yohimbine=DOWN
LYZ: Copper sulfate=DOWN, Curcumin=DOWN, Calcitriol=UP, Pirinixic acid=DOWN, Resveratrol=DOWN, Tretinoin=DOWN, Trichostatin(valproic acid)= UP
CCL18: 2,2',4,4'-tetrabromodiphenyl ether=UP, acetovanillone(aka Apocynin)=DOWN
MMP2: Halofuginone=DOWN, Tretinoin=dose-dependent, Ethanol=UP, Resveratrol=DOWN, Valproic acid=UP, Curcumin=DOWN, Berberine=DOWN, Capsaicin=UP, Copper=UP, GHK-CU=UP, Fullerene C60=UP, Genistein=DOWN, Glucosamine=AFFECTED, Ginsenoside Rg3=DOWN, Gingerol=DOWN(ok so ginger really does indeed help AGA in some way- at least by downregulating MMP2), PGE2=UP, Titanium dioxide=DOWN, Vitamin E=UP
IFI27: Phenobarbital=DOWN, Ascorbic acid=UP, Butyraldehyde=UP, Pirinixic acid=DOWN, Titanium dioxide=UP, Zinc sulfate=DOWN
HAL: Pirinixic acid=DOWN, Phenobarbital=DOWN, Calcitriol=UP, Ketoconazole=AFFECTED, Silicon dioxide=DOWN, Titanium dioxide=UP, Tretinoin=UP, Valproic acid=DOWN, Zinc=DOWN
C3: PPAR Alpha=DOWN, Genistein=UP, Titanium dioxide=UP, Mangiferin=DOWN, Ascorbic acid=UP, Androgens=UP, Curcumin=DOWN, Resveratrol=UP, Tacrolimus=UP, Isoproterenol=DOWN
ENPP4: Valproic acid=UP, Butyraldehyde=UP, Pirinixic acid=UP, Resveratrol=UP, Zinc=UP
STMN2: Valproic acid=UP, Fullerene C60=DOWN, Titanium dioxide=DOWN, Pirinixic acid=DOWN
AOX1: Valproic acid=DOWN, Phenobarbital=UP, Vitamin K3=DOWN, 2,2',4,4'-tetrabromodiphenyl ether=AFFECTED, Butyraldehyde=UP, Isoprotenol=UP, Phthalic acid=DOWN, Pirinixic acid=AFFECTED, Silicon dioxide=DOWN
ARS(aka SLURP1): Valproic acid=AFFECTED
ALDH1A1(by examining the chemicals involved here- it is easy to tell that this gene has got something to do with Reactive Oxidative Species generation. Tell-tale signs that bald scalp has got high oxidative stress levels): Pirinixic acid=UP, Phenobarbital=UP, Valproic acid=UP, Copper=UP, Ethanol=UP, Flutamide(AR blockers)=AFFECTED, Miconazole=UP, Pirinixic acid=UP, Phenytoin=UP, Resveratrol=DOWN, Silymarin=DOWN, Spironolactone=UP, Tacrolimus=DOWN, Titanium dioxide=DOWN, Tretinoin=DOWN, Zinc=DOWN
PLP1: Dibutyl Phthalate=DOWN, Valproic acid=DOWN, Caffeine=UP, Genistein=DOWN, Tretinoin=AFFECTED
CILP: Genistein=UP, Isoproterenol=UP, Pirinixic acid=UP, Copper=DOWN
CCL19: Titanium dioxide=UP, Silicon Dioxide=UP, Butyraldehyde=DOWN, Capsaicin=UP, Fullerene C60=DOWN, Zinc CHloride=DOWN
FOSB: Shikonin=UP,Copper=UP, Lithium=UP, Pirinixic acid=UP, Silicon dioxide=UP, Tretinoin=UP, Valproic acid=dose-dependent, Luteolin=DOWN,
FOS(aka c-FOS)(ok this gene has an massively-overwhelming amount of chemicals that upregulate it and is in the top 5 most downregulated gene in haired-scalp. Addressing this gene is critical in halting hairloss n regrowing hair.): Shikonin=UP, Baclofen=DOWN, Tretinoin=dose-dependent, Valproic acid=dose-dependent, Zinc=UP, Bicalutamide(AR blockers)=DOWN, Lithium Chloride=UP, Butyric acid=UP, Caffeine=UP, Bicuculline=DOWN, Carbamazepine=DOWN, Capsaicin=UP, Copper=UP, Curcumin=DOWN(especially in hypoxic conditions- like in the bald scalp), Levodopa=UP, Dopamine=UP, Ethanol=UP(a good reason why ethanol should be used as little as possible in a vehicle), Glucosamine=DOWN, Genistein=UP, Isoproterenol=UP, Lithium Chloride=UP, Resveratrol=DOWN
PTGDS: Antipyrine=DOWN, Butyraldehyde=UP, Ethanol=DOWN, Prozac=DOWN, Genistein=DOWN, Isoproterenol=UP, Titanium Dioxide=DOWN, Tetracycline(Doxycycline as well)=UP, Tretinoin=DOWN, Valproic acid=UP, Vitamin E=UP
Hence from PTGDS:
PTGDR2(aka CRTH2 aka GPR44): Ramatroban=DOWN, OC=DOWN, TM30089=DOWN, Setipiprant=DOWN, Fullerene C60=DOWN, Indomethacin=UP, PGD2=UP
CORIN: Phenobarbital=DOWN, Pirinixic acid=UP, Isoproterenol=UP, SERPINA1=DOWN
END of ALL the genes mentioned in Dr Cotsarelis's patent.
WNT3A: Valproic acid=UP, Tretinoin=DOWN, Resveratrol=UP
WNT5A: Valproic acid=UP, Calcitriol=UP, Halofuginone=UP, Phenobarbital=UP, Resveratrol=DOWN, Silicon dioxide=Down
WNT7A: Fullerene C60=UP, Tretinoin=UP, PPAR Alpha agonists=UP
WNT7B: Calcitriol=UP, Tretinoin=UP
WNT10A: Valproic acid=UP, Butyradehyde=UP, Tretinoin=DOWN
WNT10B: PGJ2=DOWN, Valproic acid=UP, Butyraldehyde=UP, p53=DOWN
Beta Catenin: Lithium Chloride=UP, Resveratrol=DOWN, Sulfasalazine=DOWN(ok it's official- sulfasalazine downregulates b-catenin), Quecertin=DOWN, Curcumin=DOWN, Valproic acid=UP, Capsaicin=UP, Corosolic acid=DOWN, Fullerene C60=UP, PGE2=UP, Pirinixic acid=UP, Vitamin E=DOWN, Tretinoin=AFFECTED, Zinc=DOWN
CD34: Valproic acid=UP, PGE2 EP2 receptor=UP
CD49F: Pirinixic acid=UP, Dibutyl Phthalate=UP, Tretioin=UP, Flutamide(AR blockers)=DOWN, Iron=DOWN, Phthalic acid=UP, Titanium dioixde=DOWN, Valproic acid=UP
CD200: Halofuginone=UP, Phenobarbital=UP, Calcitriol=UP, Tretinoin=DOWN, Valproic acid=DOWN
END
And translate it back into the findings in the Scoliosis study:
Experimental small molecule pharmalogical solutions for AGA by topical/oral route administration in order of descending preference(would be updated from time to time):
Simplified once and for all
1):
All affected genes indicated in the Scoliosis study:
TATA <= Topical/oral Palmitoylethanolamide or any PPAR Alpha receptor agonists
HNF4 <= Topical Valproic acid or any Androgen receptor inhibitors.
RAR <= Topical Tretinoin in ultra low dose
RXRA <= Topical/oral Palmitoylethanolamide or any PPAR Alpha receptor agonists.
STAT(STAT3) <= Topical Valproic acid, topical Copper
BATF <= Topical/oral Palmitoylethanolamide or any PPAR Alpha receptor agonists.
COMP <= Topical Valproic acid, topical/oral Titanium dioxide
VDR <= Topical Calcitirol/Calcipotriol, topical Valproic acid, topical Tretinoin in ultra low dose, topical/oral Palmitoylethanolamide or any PPAR Alpha receptor agonists.
HDAC2 <= Topical Valproic acid, topical/oral Fullerene C60
CART1 aka ALX1 <= Topical Valproic acid, topical Tretinoin in ultra low dose.
FOXA(this gene is the 1 primarily responsible for activating DKK1 and hence- GSK3B on the balding scalp. It is also the reason why estrogenic molecules inhibit Dkk1) <= Topical Valproic acid.
FOXP1 <= Topical Valproic acid, Topical Tretinoin in ultra low dose, topical Copper, oral/topical Titanium dioxide.
GATA(GATA3) <= Topical Valproic acid, Topical/oral Palmitoylethanolamide or any PPAR Alpha receptor agonists, oral/topical Titanium dioxide.
H6 family homeobox 2. Ok i havent figure yet whether it's an agonism or antagonoism that will deal with this gene- if it's even related to AGA, that is. Anyway there are a few drugs on the opposing ends of addressing this gene and it is IMO that it has to be done by oral route cos it seems to affect the inner ears more. Agonists: Oral Valproic acid or any oral anticonvulsants. Antagonists: Oral Fullerene C60, Oral Palmitoylethanolamide or any PPAR Alpha receptor agonists.
IRF(IRF1) <= Topical/oral Palmitoylethanolamide or any PPAR Alpha receptor agonists.
PAX5 <= Topical Tretinoin in ultra low dose.
P300<== Topical/oral Palmitoylethanolamide or any PPAR Alpha receptor agonists, topical Copper.
END
It's now easy to see the connection 1)why those genes discovered by Dr Cotsarelis were upregulated/downregulated in haired-scalp when compared to bald scalp- between those genes indicated in the Scoliosis study(Pax1/Foxa2 locus- the primary cause of AGA).
In Summary:
Pax1/Foxa2 AGA/Scoliosis haplotype variants ======> 17 altered genes in total as indicated in the Scoliosis study like RXRA, HDAC2, etc =======> altered the behavior of hundreds of downstream genes in Dr Cotarelis's patent that could be grouped into 2 main profiles:
1)Downregulation of Wnt/B-catenin pro-profileration pathway genes
2)Upregulation of Immunity and anti-profileration pathway genes;
======> AGA
This is like every hair growth study ever posted condensed down into one post....INCREDIBLE!!!
"
