Eating dietary amounts of long pepper as an added spice may be tasty and beneficial. Long pepper then would be part of the dizzying array of other components found in vegetables and fruit. But to consume it as a be-dreamed of senolytic?
I posted this thread for discussions about piperlonguminine. Nothing else.
As is expressed elsewhere on this site, hoping to kill senescent cells by using big rude amounts of long pepper is still another unknown in a long ass list of other unknowns about what kills senescent cells safely, and what does not.
See, for example:
http://www.longecity...mine-senolytic/
And more specifically, word up:
As I just posted elsewhere:
Folks, acting on this by swallowing large amounts of black pepper or Piper longum is madness ...
First, they haven't even shown that this stuff kills senescent cells in vivo, and we have no idea about a remotely rational dose for doing so. Second, we have no idea yet of the mechanism. Third, while the paper says that "the maximum tolerated dose in mice is very high," this is not remotely like safety data: it's based on the lack of acute toxic effects after 6 days' treatment.
And whether or not piperlongumine is safe or effective, swallowing mass amounts of pepper in hopes of getting an undefined minimum amoiunt of piperlongumine is not: piperine inhibits a range of xenobiotic-metabolizing enzymes, including the CYP450s and UDP-glucuronosyltransferase, potentially increasing the absorption of dietary carcinogens and other toxins (particularly in conjunction with the concomitant irritation of the intestinal wall). And while there are studies showing that piperine reduces the toxicity of endotoxin to cultured cells and tissue samples, it's entirely plausible that piperine-mediated increases in instestinal permeability could increase absorption of endotoxin, which increases systemic inflammation and has been implicated in atherosclerosis and a range of chronic diseases.
I repeat: they haven't even shown this stuff has senolytic effects in vivo yet, and are very far indeed from showing it's safe. Wait a while, OK? There's senolytic drugs and Oisín's non-integrating genetic senescent cell ablation system coming down the pipe, and they have animal data. There's nothing more embarrassing than dying prematurely from a foolish life extension experiment.
