3 replies to this topic

[alc]

https://www.scienced...70308083940.htm

 

http://www.impactjou...ew&path[]=15400

[jjnz]

Don't you love how science catches up with the sceptics, the quackwatch website is full of stories against vitamin C and against Linus pauling. Real science of course keeps looking it doesn't jump to conclusions and now it appears that sceptics have nothing to say on the matter not even that they were wrong

Edited by jjnz, 13 March 2017 - 11:16 PM.

[alc]

Don't you love how science catches up with the sceptics, the quackwatch website is full of stories against vitamin C and against Linus pauling. Real science of course keeps looking it doesn't jump to conclusions and now it appears that sceptics have nothing to say on the matter not even that they were wrong

 

There are lots of pooh-poohers around (just here on this forum you find seven-sins-of-aging followers that cannot comprehend something else ... )

 

Anyway, the cause of vitamin C is far from being closed, but the main cause of failure was how much and how was delivered. That is probably Pauling failed to show results.

 

Here is another example of recent work:

 

"Why high-dose vitamin C kills cancer cells"

 

https://now.uiowa.ed...ls-cancer-cells

 

https://www.ncbi.nlm...70/pdf/main.pdf

 

Just these small steps, if they are taken well, could improve a lot the life of beings. It is not "reverse aging", but could lead to very good things for all of us.

 

And also this recent study:

 

"Retinol and ascorbate drive erasure of epigenetic memory and enhance reprogramming to naïve pluripotency by complementary mechanisms"

 

http://www.pnas.org/...nt/113/43/12202

[Logic]

What I find interesting is that vit C slows/stops cancerous stem cell growth as this ties in with Navitoclax killing off senescent, often pre/cancerous, stem cells.
http://www.longecity...ndpost&p=808619
 
Also interesting from this POV is the other substances they found.
Some stronger than vit C:

...they measured the impact on cell lines in a laboratory of 7 substances, the clinically-approved drug stiripentol, 3 natural products –caffeic acid phenyl ester (CAPE), silibinin and ascorbic acid – and experimental pharmaceuticals, such as actinonin, FK866 and 2-DG.

While they found that natural antibiotic actinonin and the compound FK866 were the most potent, the natural products also inhibited CSC formation, with Vitamin C, outperforming 2-DG by tenfold in terms of potency...

https://nutritionrev...cer-stem-cells/

 

...we have now identified a variety of clinically-approved drugs (stiripentol), natural products (caffeic acid phenyl ester (CAPE), ascorbic acid, silibinin) and experimental pharmaceuticals (actinonin, FK866, 2-DG), that can be used to effectively inhibit CSC activity. We discuss the use of CAPE (derived from honey-bee propolis) and Vitamin C, as potential natural therapeutic modalities. In this context, Vitamin C was ~10 times more potent than 2-DG for the targeting of CSCs. Similarly, stiripentol was between 50 to 100 times more potent than 2-DG...

http://www.impactjou...ew&path[]=15400
 

More interesting is the antibacterial activity of actinonin, as the infection of cells by various pathogens is proven to stop the apoptosis of senescent cells.
Pathogens are also very often implicated in cancers as is evident from the anti cervical cancer vaccine for example, the fact that vit C itself has anti pathogenic properties and papers like the one below:

 

Peptide deformylase (PDF) is an essential bacterial metalloenzyme which deformylates the N-formylmethionine of newly synthesized polypeptides and as such represents a novel target for antibacterial chemotherapy. To identify novel PDF inhibitors, we screened a metalloenzyme inhibitor library and identified an N-formyl-hydroxylamine derivative, BB-3497, and a related natural hydroxamic acid antibiotic, actinonin, as potent and selective inhibitors of PDF. To elucidate the interactions that contribute to the binding affinity of these inhibitors, we determined the crystal structures of BB-3497 and actinonin bound to Escherichia coli PDF at resolutions of 2.1 and 1.75 Å, respectively. In both complexes, the active-site metal atom was pentacoordinated by the side chains of Cys 90, His 132, and His 136 and the two oxygen atoms of N-formyl-hydroxylamine or hydroxamate. BB-3497 had activity against gram-positive bacteria, including methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus faecalis, and activity against some gram-negative bacteria. Time-kill analysis showed that the mode of action of BB-3497 was primarily bacteriostatic. The mechanism of resistance was via mutations within the formyltransferase gene, as previously described for actinonin. While actinonin and its derivatives have not been used clinically because of their poor pharmacokinetic properties, BB-3497 was shown to be orally bioavailable. A single oral dose of BB-3497 given 1 h after intraperitoneal injection of S. aureus Smith or methicillin-resistant S. aureus protected mice from infection with median effective doses of 8 and 14 mg/kg of body weight, respectively. These data validate PDF as a novel target for the design of a new generation of antibacterial agents.

https://www.ncbi.nlm...icles/PMC90327/

 

​In summary:

Senescent, pre/cancerous stem and other cells cause serious shit; from senescent cell buildup to recurrent cancers.
Pathogens, often a combo of bacterial and viral infections, are very often the culprits behind all these pro aging and cancer issues.

Edited by Logic, 03 April 2017 - 11:01 AM.