Doctors are starting to wake up about hormone replacement therapy... unfortunately the medical industry is coming from an overtly conservative starting point. TRT can save lives, and improve quality of life.
Unfortunately in Australia, where I live, what is considered low testosterone is below 200ng/dL! This is ridiculous, as low testosterone symptoms can start as high as 450ng/dL.
I hope the undecanoate ester becomes cheaper and more widely available, as it seems like the most time-efficient reliable replacement.
"When most doctors learned about testosterone in medical school, they learned about total testosterone, or all the testosterone in the body. But about half of the testosterone that’s circulating in the bloodstream is not available to the cells. It’s tightly bound to a carrier molecule called sex hormone–binding globulin, which we abbreviate as SHBG.
The biologically available part of total testosterone is called free testosterone, and it’s readily available to the cells. Almost every lab has a blood test to measure free testosterone. Even though it’s only a small fraction of the total, the free testosterone level is a pretty good indicator of low testosterone. It’s not perfect, but the correlation is greater than with total testosterone.
I think that the biggest hurdle for most physicians prescribing testosterone is the fear that they’re going to promote prostate cancer. [See “Incongruous findings,” below.] That’s because more than six decades ago, it was shown that if you lowered testosterone in men whose prostate cancer had metastasized, their condition improved. (It became a standard therapy that we still use today for men with advanced prostate cancer. We call it androgen deprivation or androgen-suppressive therapy.) The thinking became that if lowering testosterone makes prostate cancer disappear, at least for a while, then raising it must make prostate cancer grow. But even though it’s been a widely held belief for six decades, no one has found any additional evidence to support the theory.
I think that the importance of testosterone for cardiovascular health is going to be increasingly recognized. In the past, because men die of heart attacks more often than women and men have more testosterone, the fear has been that testosterone causes heart problems. But every single study of whether testosterone is bad for the heart has been negative, and what people haven’t pointed out in most of those negative studies is that there may be a beneficial effect.
I think we’ll also find out in five years that there very well may be general health benefits of having normal testosterone compared to low testosterone. There are growing data for all-cause mortality that men who have low testosterone die earlier than those who have normal testosterone. A study by the Veterans Administration reported about a year ago showed low testosterone levels were associated with a dramatically increased mortality rate. It’s hard to know why that is, but I think we’ll be focused on that in the coming years."
http://www.harvardpr...acement-therapy
Other than testosterone, the industry should be looking more into mixing transdermal creams with Undecanoate and Nandrolone. Creams can help replicate the circadian rhythm of testosterone and estrogen, while Undecanoate can prevent serum crashes, and Nandrolone's progesterone affinity could be useful for many men. Further adjuncts to be considered are: pregnenolone, dhea, ibutamoren and boron.
Who here is on HRT, and what are people's opinions on the matter?
Edited by Adam Karlovsky, 17 March 2017 - 02:34 AM.
