Edited by soulprogrammer, 28 March 2017 - 12:14 PM.
Killing senescent cells using electromagnetic
#1
Posted 28 March 2017 - 12:12 PM
#2
Posted 28 March 2017 - 12:21 PM
Maximal tetanic tension was elicited at 200, 150, and 150 Hz in control tibialis anterior muscles and at 150, 100, and 100 Hz in 14-day regenerating muscles of young (3 months), adult (18 months), and old (31 months) Fischer 344/Brown Norway F1 rats, respectively. In contrast to young rats, increasing stimulation frequency from 50 to 150 Hz did not elicit significantly greater tetanic tension in control or regenerating muscles of old rats. At higher stimulation frequencies, tetanic fade was prevalent in control and regenerating muscles of adult (250–300 Hz) and old rats (200–300 Hz), but was only present at 14 days of recovery in regenerating muscles of young rats (300 Hz). The decreased efficacy of rehabilitative and physical medicine procedures in adult and elderly patients who have suffered skeletal muscle injury could be explained, in part, by the postulate that tetanic fade is indicative of inadequate synaptic transmission. © 1998 John Wiley & Sons, Inc. Muscle Nerve 21:1265–1274, 1998.
#3
Posted 28 March 2017 - 12:25 PM
It's borderline tinfoil hat stuff. And the conflict of interest statement should have one derating it by 90%--
Conflict of interest: Boris Pasche and Alexandre Barbault have filed applications for patent protection and hold patents related to electromagnetic fields amplitude-modulated at tumor-specific frequencies as they relate to the diagnosis and treatment of cancer. They hold stocks in TheraBionic.
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#4
Posted 14 July 2017 - 04:57 PM
It's borderline tinfoil hat stuff. And the conflict of interest statement should have one derating it by 90%--
Conflict of interest: Boris Pasche and Alexandre Barbault have filed applications for patent protection and hold patents related to electromagnetic fields amplitude-modulated at tumor-specific frequencies as they relate to the diagnosis and treatment of cancer. They hold stocks in TheraBionic.
Some organism survival probability studies about NF-kB Nuclear Translocation and Cytokine Transcription and Inhibition of those functions can be found here...
Also, NF-kB has been found to manage Senescence and SASP, here and there and inhibiting it provides cellular senescense related benefit.
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Context • During cell-communication processes, endogenous and exogenous signaling affects normal and pathological developmental conditions. Exogenous influences, such as extra-low-frequency (ELF) electromagnetic fields (EMFs) have been shown to affect pain and inflammation by modulating G-protein coupling receptors (GPCRs), downregulating cyclooxygenase-2 (Cox-2) activity, and downregulating inflammatory modulators, such as tumor necrosis factor alpha (TNF-α) and interleukin 1 beta (IL-1β) as well as the transcription factor nuclear factor kappa B (NF-κB). EMF devices could help clinicians who seek an alternative or complementary treatment for relief of patients chronic pain and disability.
Objective • The research team intended to review the literature on the effects of EMFs on inflammatory pain mechanisms.
Design • We used a literature search of articles published in PubMed using the following key words: low-frequency electromagnetic field therapy, inflammatory pain markers, cyclic adenosine monophosphate (cAMP), cyclic guanosine monophosphate (cGMP), opioid receptors, G-protein coupling receptors, and enzymes. Setting • The study took place at the Wake Forest School of Medicine in Winston-Salem, NC, USA. Results • The mechanistic pathway most often considered for the biological effects of EMF is the plasma membrane, across which the EMF signal induces a voltage change. Oscillating EMF exerts forces on free ions that are present on both sides of the plasma membrane and that move across the cell surface through transmembrane proteins. The ions create a forced intracellular vibration that is responsible for phenomena such as the influx of extracellular calcium (Ca2+) and the binding affinity of calmodulin (CaM), which is the primary transduction pathway to the secondary messengers, cAMP and cGMP, which have been found to influence inflammatory pain.
Conclusions • An emerging body of evidence indicates the existence of a frequency-dependent interaction between the mechanical interventions of EMF and cell signaling along the peripheral inflammatory pain pathway.
And there are a good many more about electromagnetic wave therapy like that.
Evolution has been establishing mechanisms in mammals, including in humans, over millions of years, that, when triggered safely, even in ways that surprise us, can increase survival probability and improved health. A benefit of learning about and deliberate triggering of these mechanisms is that they implicate fewer, if any, negative side effects...
Edited by HighDesertWizard, 14 July 2017 - 05:05 PM.
#5
Posted 22 July 2017 - 04:36 PM
I built my own Lakhovsky device after I read that a NASA study showed that EMF pulses could change gene expression - pushing that towards regeneration and growth.
I think the device may have worked but not for the reasons everyone thought. It has nothing to do with resonance. It involves a hormetic response to HV pulse exposure. Unfortunately, there is too much "Frankenstein" silliness associated with this subject - and that prevents serious research.
#6
Posted 23 July 2017 - 09:44 PM
I think the device may have worked but not for the reasons everyone thought. .... It involves a hormetic response to HV pulse exposure. Unfortunately, there is too much "Frankenstein" silliness associated with this subject - and that prevents serious research.
Agree. And more specifically...
Effect of 60 Hz electromagnetic fields on the activity of hsp70 promoter: an in vivo study
But there's also this...
Here's a question I have...
Is increased HSP 70 expression implicated in all hormetic response contexts?
Edited by HighDesertWizard, 23 July 2017 - 09:52 PM.
#7
Posted 30 July 2017 - 03:54 AM
Years ago I was given a wristwatch that had a 7.8 Hz (approx) Schumann resonance frequency oscillator inside it. Since we evolved in a Schumann resonant frequency environment, the watch was hyped as an electromagnetic pollution antidote. It was a nice looking watch. I wore it for a year or two, and didn't notice any effect, except for the following experience:
One day I ran into an engineer that was attempting to market a handheld instrument that focused infrared energy from a point 6 inches away and could look inside the human body. It was very sensitive to tiny temperature variations and showed a time trace of temperature. He aimed it at my shoulder on the same side as my wristwatch. The temperature trace was chaotic until I imagined myself floating on a cloud. We then saw the temperature inside my shoulder varying at the schumann resonant frequency. This stopped when I removed the wristwatch. I was amazed that my body temperature could vary (by a very small amount) in sync to that wristwatch.
Edited by RWhigham, 30 July 2017 - 03:56 AM.
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