2 replies to this topic

[bitstorm]

I would love to hear some contrary evidence to the angle this article is taking... especially as I've just bought a big bunch of Metacurcumin

 

Perhaps Anthony Loera can comment?

 

 

"There is, however, an even bigger reason why curcumin has not cured dozens of diseases. There are compounds which researchers call pan-assay interference compounds, or PAINS. These are compounds that seem to have a lot of activity against specific proteins, but it turns out they are false positives. The assays used to test for such protein activity show artifacts of non-specific activity which mimics specific protein activity.

Curcumin is apparently one of the worst offenders. In a commentary for Science Translational Medicine, Derek Lowe details why curcumin is so bad:

The paper cites a long list of references demonstrating that curcumin participates in pretty much every undesirable behavior possible in an assay: it reacts with proteins, it’s a redox cycler, it coordinates metal ions, it aggregates, it disrupts membranes nonspecifically, it interferes with fluorescent readouts, and it decomposes. Other than that, it’s a perfectly good hit.

Other reviewers call curcumin an “invalid metabolic panacea,” which is a term used to describe compounds, mostly natural compounds like curcumin, which seem to have all sorts of biological activity but nothing that amounts to a useful clinical effect."

https://sciencebased...om-iv-turmeric/

[joelcairo]

Right, every researcher in the field has made egregious mistakes invalidating their work except for Derek Lowe. Anyway this would only apply to in vitro testing, ignoring the enormous amount of in vivo evidence. Not to mention some clinical evidence, but not a huge amount yet.

[Anthony_Loera]

Hi bitstorm, I think I already replied to you by email

 

Here it is once more:

======================================

 

Hi <bitstorm>,

 

I just read the article, it is pretty scary stuff. 

 

As I read it, a couple things came to mind:

 

1- First, a recent conversation with a Medical Doctor regarding IV transfusion. 

The fact is that if you are not medically trained, lots of bad things can happen if you try to use an IV to take in a drug, even if the drug is determined to be completely safe... (even if its not a drug at all and simply a 'placebo'). The article reminds me that you should never trust someone who is not medically trained to inject you with anything as the risk is too great. 

 

The simple fact is that some IV medical treatments can suddenly drop blood sugar if administered too quick. Also, something like (insert most dietary supplements here) can probably cause huge electrolyte shifts, so proper calcium, magnesium, and potassium supplementation will be crucial. Any person who is not a medically trained doctor will likely know nothing about all of this and could unintentionally hurt or kill you. 

 

I am actually horrified a "Naturopath" was allowed to do this.

 

2- The article writter only focused on cell and animal studies (no human studies) to try and put Curcumin in a negative light. However, there are human clinical trials with some interesting observations on curcumin that the article writer never touches upon. I find it odd since the writer is a pretty smart medical doctor that probably knows his way around searching the science journals:

 

I copied the following from a list I have:

=============================

Improvement in Oxidant Stress - 21 People (link) 

Curcumin protects from DNA damage - 286 People (link) 

Antioxidant effect in pancreatitis - 20 People (link) 

Diverse positive effects in people - 38 People (link) 

Reduction in oral inflammation - 20 People (link) 

Decrease joint pain and improved function - 100 People (link) 

Ulcerative colitis maintenance therapy - 89 People (link) 

Reduce blood pressure - 24 People (link) 

Changes for type 2 diabetic nephropathy - 40 People (link) 

Laparoscopy postop pain improvement- 50 People (link) 

Management of osteoarthritis- 100 People (link) 

More management of osteoarthritis- 50 People (link) 

Acetominaphen vs Curcumin - 15 People (link)

Improve vascular endothelial health - 32 People (link) 

=============================

 

In the end I can only assume he overlooked these as he was focusing on the main issue, which was how diluting the legal term of "Physician" can be detrimental, and hence uses the death to drill this point home. 

 

The article writer actually really gets into it here about this legal 'dilution' and I have to agree with him:

https://sciencebased...a-physician-is/

 

Whatever the case, the article provides a perfect example of why folks are asked to seek advice from their Medical Doctors if they are not healthy, as Naturopaths are clearly not medically trained.

 

If the purpose of the article was to try and change people's minds and to stop regarding Neuropathy, Naturopaths or "Naturopathic Physicians" as medical professionals, then he has clearly convinced me.

 

Anthony