In the study Mitochondrial Fusion Is Essential for Steroid Biosynthesis, if I have understood correctly, fusion is needed for the conversion of cholesterol to pregnenolone.
Our results indicate that fusion per se is obligatory for steroid biosynthesis
That seems to imply that pregnenolone production is reduced when in fission, like after taking N+R.
I get a great energy boost from pregnenolone at 50 mg, lots of mental energy all day and a noticeable increase in endurance exercise capacity. I get just the opposite with higher doses of fission promoters, making me wonder if the fission blahs might be partly due to low pregnenolone.
If that's the case, then supplementing with pregnenolone might make taking fission promoters easier.