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Manipulating mitochondrial dynamics

nad nad+ c60 mito fission fusion stearic acid mtdna methylene blue

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2296 replies to this topic

#2281 zorba990

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Posted 18 November 2024 - 12:18 AM

You need at least 100-120 mg PQQ. Turnbuckle said that PQQ was the crucial supplement that made it all work. High dose required.


Do we have a reliable brand for PQQ?

#2282 Blueflash

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Posted 18 November 2024 - 10:54 AM

Do we have a reliable brand for PQQ?



#2283 Blueflash

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Posted 18 November 2024 - 10:57 AM

Im using a brand called BestVite. I chose it because it doesn’t have too many fillers. I can feel more focused, better memory and enhanced gym performance with it.

#2284 Advocatus Diaboli

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Posted 18 November 2024 - 03:09 PM

Bestvite seems to be an efficient operation. They do the manufacturing and distributing of more than 200 products (look above the "7-Keto" bottle on this page). Not too shabby for a company of 7 to maybe 15 employees. Their manufacturing facilities must be pretty impressive. Also, they have earned a reputation of being "The most trusted name in vitamins"--USPTO says so.  


Edited by Advocatus Diaboli, 18 November 2024 - 03:24 PM.

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#2285 PAMPAGUY

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Posted 18 November 2024 - 04:21 PM

https://cdn.consumerlab.com

 

 

HSN and Doublewood were cheapest per 20mg and passed test


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#2286 stephen_b

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Posted 20 December 2024 - 11:15 PM

I took 2g AAKG and 100 mg PQQ in the morning. At 6 PM that day I did a shorter 3.5 mile run which was better than average.

 

The following morning though I set a recent PR for push-ups at 60. Recently I had not been able to do more than a mid-40's count of push-ups. I wonder if the maximization of the benefits take more than 1 day.

 

I think I'm going to avoid taking the regular fission supplements (N+R 1 g, AAKG 1 g, PQQ 20 mg). The 2g AAKG and 100 mg PQQ feels much more restorative.


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#2287 kurt9

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Posted 21 December 2024 - 12:41 AM

This new protocol is cheaper and certainly much easier than the regular one.


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#2288 Repack Racing

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Posted 21 December 2024 - 11:20 PM

This protocol has had ZERO effect on anything related to athletics for me.


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#2289 stephen_b

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Posted 27 January 2025 - 05:10 PM

I was unaware of sulforaphane being a big fusion promoter.

 

Sulforaphane is a Nrf2-independent inhibitor of mitochondrial fission

 

We demonstrate here that the mitochondria of cultured, human retinal pigment epithelial (RPE-1) cells treated with SFN undergo hyperfusion that is independent of both Nrf2 and its cytoplasmic inhibitor KEAP1.

 

 


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#2290 stephen_b

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Posted 10 February 2025 - 05:46 PM

In Turnbuckle's earlier post on restoring mitochondrial function (link), the protocol is:

 

Fission: 500mg niacinamide, 1g AAKG, and 20mg PQQ

Fusion: 300mg DHM, 1g AAKG, and 20mg PQQ

 

I have not felt much benefit from the DHM. I'd like to propose 1g Meriva curcumin in its place, with or without Broccomax sulphurophane.

 

 
 
 
Curcumin has been reported to enhance the fusion activity, reduce fission machinery, and increase biogenesis and synaptic proteins. Elevation in mitochondrial function and cell viability has been shown with curcumin treatment. Curcumin might improve mitochondrial potential and ATP and restore mitochondrial fusion, probably by upregulating PGC-1α protein expression.
 

Edited by stephen_b, 10 February 2025 - 05:50 PM.

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#2291 kurt9

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Posted 10 February 2025 - 06:20 PM

Would the single dose of 100-120 mg of PQQ along with the AAGK be considered the replacement for the above/


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#2292 stephen_b

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Posted 11 February 2025 - 12:54 AM

Would the single dose of 100-120 mg of PQQ along with the AAGK be considered the replacement for the above/

 

I was under the impression that the PQQ/AAKG was for mitochondrial methylation issues he spoke of in the reversing MS article as opposed to normal mitochondrial errors.


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#2293 bullGenteel

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Posted 07 March 2025 - 09:44 PM

I was reading the updates made by Turnbuckle. I thought it sounded like he used lactic acid once for his newly devised latching method.

Im a little scatterbrained in my approach. I have had a mild to moderate concussion and I have moderate/severe ocd. I first tried the new protocol with pqq around 60-80mg 6 monnths ago, no lactic acid, like others here have tried. I used it after doing 3 or 5 day fasts that included the stem cell protocol. These took a lot out of me. It felt like it took a couple weeks to recover my strength using the old mitochondria protocol or this updated version, just using 60- 80mg pqq, no lactic acid.

I am sure I may have greater placebo or psycho somatic tendencies than the average person. I felt like I bounced back, almost immediately the day of doing the latching method with lactic acid after doing 3 day fastlt combined wi5h stem cell protocol. The first time I took 2g or roughly a teaspoon of lactic acid with 100mg of pqq or there abouts. I don't take notes. I take 2g akg and 100mg pqq and lactic acid. Than an hour or so later I take a little more akg and calcium lactate. I try to save money by only taking pqq once, with the half life this may work I thought.
I have only used this version once in a week. I use 2.5 teaspoons of lactic acid and teaspoon of glycine for fission. I tried to research on my own. I don't have a science background. The lactic acid supposedly does the opposite of calcium lactate and the two csncel each other out, as far as I read. Unless the way they are processed in the body is different than how I thought I read it.

I had some ocd/hypochondriac anxiety around lactic acid. There is lethal dose for animals. Don't quote me I think it is something like 23mg for mice or humans. I did this reading few months ago. I don't really take. Notes. I am still recovering from a brain trauma. I felt fine taking about 5g of lactic acid. 2.5 teaspoons roughly 5g, if my math is right. I got it from a brewing company. It is 88% lactic acid. I take it with a full cup of water. It kinda jilted my system taking it first time. I'm sure it should be diluted with water. If you have an gastric issues it is not recccomened I would strongly warn against.

I also took 5g glycine with it and 2g akg and 80-120mg pqq.

I never had an account up until now. I've been a little scatterbrained too. Maybe others could share thier thoughts on what I have tried. I just based off what I thought I read. The only addition is I thought I read lactic acid was used as a fission agent. I have used this prot9cl about onc3 a month since October last year.

I did do the original mitchondria protocol with great results back in fall of 2022. I have kept up with it off and on and used the atomic protocol for exercise a few times a month.

Maybe I will .ake a post about what I have learned in my work in myself the last 4 years or so. Using this website. For a moderate concussion as well as some severe inherited mental health issues.

I just wanted to add my experience to the discussion.
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#2294 Logic

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Posted 14 March 2025 - 11:07 AM

I NB the effects of Sildenafil + Leucine  and Icariin + Leucine on the synthesis of mitochondria here:
https://www.ergo-log...ed-leucine.html

#2295 Repack Racing

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Posted 17 March 2025 - 07:30 PM

Squad-

 

Turnbuckle has announced he is publishing a new 3x more effective protocol in about a month.

 

As a reminder, here is a link to the most recent article he published: https://www.linkedin...dischler-snu5f/

 

I hadn't done the latching protocol for a while because I was working on other stuff, but today I took:

 

5g Glycerol

 

2 hours later:

 

140mg PQQ

2g AAKG

7g Sports Legs

 

Anyone else have any updates?

 

 


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#2296 PAMPAGUY

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Posted 27 March 2025 - 05:38 PM

Turnbuckles latest latching formula for increasing ATP.

 

https://www.linkedin...ae9pE6/J7uF0g==



#2297 Repack Racing

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Posted 27 March 2025 - 05:40 PM

Turnbuckles latest latching formula for increasing ATP.

 

https://www.linkedin...ae9pE6/J7uF0g==

 

See my questions in the comments - please add if there are further questions to clarify the protocol.







Also tagged with one or more of these keywords: nad, nad+, c60, mito, fission, fusion, stearic acid, mtdna, methylene blue

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