68 replies to this topic

[Oinen]

The studies done with mice for the past 5 years has been NMN in water. I think NR is the one that only raises NAD+ in the liver; you want NMN to increase NAD+ in all the cells it seems? NMN sublingually seems to be the best route to go if you want to also increase NAD+ in the brain. If you have the money, why not do NMN sublingually, ingest NR, and also NAD+ sublingually?

I personally think Pterostilbene's main benefit is its blood glucose lowering effects, since we know that lower blood gluecose is tied with lowered aging biomarkers. Also suppresses hunger if you want to skip a meal a day, since the feeling of hunger also triggers SIRT1 activation if I understood Sinclair correctly.

Pterostilbene seems to work as good as Metformin in lowering blood gluecose, I don't remember the video I saw that from, but it was from some doctors discussing studies done with Pterostilbene. As for Resveratrol, it's cheap enough and harmless, so that's why Sinclair probably takes it. He figures, why not? In case something is found out about it later.

When he talked about his dad, it seemed as if he was getting his dad to take the modified NMN molecule that Sinclair has been using in mice studies, and since his dad was a retired biochemist or something, felt confident with taking it.

Seems like you guys are missing half of the discussion here, where Sinclair talks about the many, many modified NMN versions he and his team have been testing, with one version increasing mice lifespan by 50% - saying it was the equivalent of a 150 year old human. Granted, I think there have been other things that have increased longevity in mice, such as C60/Fullerenes https://www.scienced...142961212003237

Edited by Oinen, 26 March 2019 - 02:51 AM.

[bluemoon]

 
When he talked about his dad, it seemed as if he was getting his dad to take the modified NMN molecule that Sinclair has been using in mice studies, and since his dad was a retired biochemist or something, felt confident with taking it. 

 

I realize this is Sinclair, but he has always stated he and his father take NMN, not a modified version.

[Slobec]

He say i at least two interviews that metformin is also sirt1 activator and that he takes it i the evening and rasveratol in the morning (same?)   https://www.frontier...2018.00657/full

[AlxM]

So confusing reading this thread which way to go...take NMN or NR. Seems like there’s no clear consensus.

[bluemoon]

So confusing reading this thread which way to go...take NMN or NR. Seems like there’s no clear consensus.

 

My guess is that both do something and both are hyped for healthy people.

[Slobec]

So confusing reading this thread which way to go...take NMN or NR. Seems like there’s no clear consensus.

 

If you take them orally, neither is better than niacinamide (to which they are metabolised) and can't pass liver metabolism, only small amounts reach blood. Nicotinic acid (say, 3x1g) and niacinamide (from 2x100mg to 3x500mg) with equal amounts of betaine may be better. Especially nicotinic acid for liver, kidneys, small intestine, hearth, astrocytes (half of brain cells and major supplier of NAD to neurons), even for skin. Just use google, you have bunch studies about which form of B3 increase NAD levels in diferent tissues. 

[osris]

Sinclair is a scam artist. Resveratrol does nothing at low doses. At high doses it is harmful and raises LDL. A NMN mice study showed 300mg/kg only raised NAD+ by 14% in the liver and muscle while another paper showed 185mg/kg NR raised NAD+ by 100%. NR is about 64 fold more effective than NMN at raising NAD+.

 

According to ChatGPT:

"Regarding its effects on blood lipids, a dose-response meta-analysis of randomized controlled trials (RCTs) was conducted to explore the effects of resveratrol supplementation on the lipid profile. The results indicated that the intake of resveratrol could significantly decrease total cholesterol, LDL cholesterol, and triglycerides [1]. However, it's important to note that this analysis focuses on the effects of resveratrol supplementation and does not specify the dosage range."

[osris]

They are both wrong. NAD+ is the real activator. Resveratrol and pterostilbene don’t activate Sirt1. Elysium basis trial revealed the bad effects of pterostilbene. NR in its own is very effective at lowering cholesterol. But that effect is negated by pterostilbene. If Resveratrol and pterostilbene can’t improve metabolism and actually make it worse, then they are not Sirt1 activators. So far only NR and NMN are effective Sirtuin activators. NAM and Niacin can increase NAD+, but the positive effect from higher NAD+ is countered by their inhibitory effect on Sirt1. http://www.timelessl...atio-influence/

 

According to ChatGPT:

"Based on the information provided, the statement "Resveratrol and pterostilbene don't activate Sirt1" is not entirely accurate. Resveratrol has been shown to activate Sirt1, specifically human SIRT1, in various studies. It is a polyphenol that has been reported to activate Sir2 enzymes, including SIRT1, both in vivo and in vitro [1][2][4]. Resveratrol's activation of SIRT1 has been associated with several biological processes, including gene silencing, regulation of p53, fatty acid metabolism, cell cycle regulation, and life span extension [1].

 

On the other hand, the information available does not directly confirm or refute the statement regarding pterostilbene's activation of Sirt1. However, pterostilbene, a resveratrol derivative, has been researched for its potential health benefits and has shown positive effects in various studies [5][6][7][8][9][10][11]. These studies highlight pterostilbene's potential as an activator of SIRT1 or its positive effects on various health conditions, including cholestasis, skeletal muscle oxidative stress injury, and cardiotoxicity.

 

In summary, while resveratrol has been demonstrated to activate SIRT1, the available information suggests that pterostilbene may also have SIRT1-activating properties or positive effects on SIRT1-related processes. However, further research is needed to fully understand the extent and mechanisms of their activation of SIRT1 and their specific effects."

[osris]

Sinclair bit all over the place on what he takes over time, so in reality, he's a bit like many of us. Even in his interviews, I've not heard any rationale for how much he takes, or even why he still take it, other than he says he's "more familiar" with resveratrol and so he and his father both take 1000 mg/day (along with other supps like NMN, etc.. One thing I would like to know is, 'is he taking resveratrol say, as a Japanese knotweed sourced product, which has a varying amount of trans-resveratrol plus cis-resveratrol or 100% trans-resveratrol'. As one would hope, as a scientist, he's being specific, but he hasn't said as far as I know.

 

It would make a big difference and something we to consider if trying to emulate his regime.

 

As of now (June 2023) he is taking resveratrol again. So even though the age test he took in 2017 gave him an age of 58 while he was on resveratrol the first time round, there must be something good about it for him to be taking it again.