The studies done with mice for the past 5 years has been NMN in water. I think NR is the one that only raises NAD+ in the liver; you want NMN to increase NAD+ in all the cells it seems? NMN sublingually seems to be the best route to go if you want to also increase NAD+ in the brain. If you have the money, why not do NMN sublingually, ingest NR, and also NAD+ sublingually?
I personally think Pterostilbene's main benefit is its blood glucose lowering effects, since we know that lower blood gluecose is tied with lowered aging biomarkers. Also suppresses hunger if you want to skip a meal a day, since the feeling of hunger also triggers SIRT1 activation if I understood Sinclair correctly.
Pterostilbene seems to work as good as Metformin in lowering blood gluecose, I don't remember the video I saw that from, but it was from some doctors discussing studies done with Pterostilbene. As for Resveratrol, it's cheap enough and harmless, so that's why Sinclair probably takes it. He figures, why not? In case something is found out about it later.
When he talked about his dad, it seemed as if he was getting his dad to take the modified NMN molecule that Sinclair has been using in mice studies, and since his dad was a retired biochemist or something, felt confident with taking it.
Seems like you guys are missing half of the discussion here, where Sinclair talks about the many, many modified NMN versions he and his team have been testing, with one version increasing mice lifespan by 50% - saying it was the equivalent of a 150 year old human. Granted, I think there have been other things that have increased longevity in mice, such as C60/Fullerenes https://www.scienced...142961212003237
Edited by Oinen, 26 March 2019 - 02:51 AM.