6 replies to this topic

[ta5]

J Nutr Health Aging. 2017;21(3):314-319.

Anti-Aging Effect of Riboflavin Via Endogenous Antioxidant in Fruit fly Drosophila Melanogaster.

Zou YX1, Ruan MH, Luan J, Feng X, Chen S, Chu ZY.

OBJECTIVES: This study investigated the effect of riboflavin on aging in Drosophila melanogaster (fruit fly).

DESIGN: Experimental study.

SETTING: Naval Medical Research Institute.

PARTICIPANTS: Fruit fly Drosophila melanogaster.

INTERVENTION: After lifelong supplement of riboflavin, the lifespan and the reproduction of fruit flies were observed. Hydrogen peroxide (H2O2) was used to mimic oxidative stress damage to fruit flies and the survival time was recorded.

MEASUREMENTS: The activity of copper-zinc-containing superoxide dismutase (SOD1), manganese containing SOD (SOD2) and catalase (CAT) and lipofuscin (LF) content were determined.

RESULTS: Riboflavin significantly prolonged the lifespan (Log rank χ2=16.677, P<0.001) and increased the reproductive capacity (P<0.01 for day 15; P<0.05 for day 30) of fruit flies by lifelong supplement. The survival time of fruit flies damaged by H2O2 was significantly prolonged (Log rank χ2=15.886, P<0.001), the activity of SOD1 (P<0.01) and CAT (P<0.01) was enhanced, and the accumulation of LF (P<0.01) was inhibited by riboflavin supplement.

CONCLUSION: Riboflavin prolonged the lifespan and increased the reproduction of fruit flies through anti-oxidative stress pathway involving enhancing the activity of SOD1 and CAT and inhibiting LF accumulation. Riboflavin deserves more attention for slowing human aging.

PMID: 28244572

[mrkosh1]

Inhibiting lipofuscin, glucosepane, and other waste products won't do much to reverse aging -- if anything at all. What we need are substances that can break these molecules so they can be removed from the body.

[PeaceAndProsperity]

I think there is already a method for the body to remove these things. It's proven already that significantly reducing lipoprotein(a) can reverse atherosclerosis. So where does the accumulated lpa go? Obviously the body can remove them.

[maxwatt]

lipoprotein is not a cross linked protein; age breakers are needed to reverse glucosopane (the skin cross-links contributing to wrinkles).

[PeaceAndProsperity]

They always say that there is NO way to remove those things unless highly expensive pharmaceuticals are designed especially for this task (LOL) and it always proves to be false, that there is an endogenous way to remove these "toxins" and they accumulate for good reasons (take lipoprotein that repairs the arteries, take amyloid beta that is neuroprotective, etc.).

 

It is only very rarely that these "toxins" don't serve a purpose (like calcium in arteries)

[PeaceAndProsperity]

Why do misfolded proteins only accumulate when you reach your 40s and above? Why not in your 20s? 20 years is actually very old if you have any understanding of biology. Most animals don't live past around that age.

What about misfolded proteins caused by genetic mutations like marfan syndrome. Do you really think that even if you fixed the mutated gene or genes so the body was producing the right proteins, you'd still need to remove the old misfolded protein? That doesn't seem to be right.

[Mind]

They always say that there is NO way to remove those things unless highly expensive pharmaceuticals are designed especially for this task (LOL) and it always proves to be false, that there is an endogenous way to remove these "toxins" and they accumulate for good reasons (take lipoprotein that repairs the arteries, take amyloid beta that is neuroprotective, etc.).

 

It is only very rarely that these "toxins" don't serve a purpose (like calcium in arteries)

 

If you know of a way to easily break down different forms of lipofuscin, glucosepane, and other types of AGE, you should contact SENS and let them know. They have been working on the problem for over a decade now. 

 

Maybe contact the Speigel lab as well with your knowledge of inter and intracellular junk: http://www.longecity...pane-synthesis/ They are working very hard on a way to break down glucossepane.