J Nutr Health Aging. 2017;21(3):314-319.
Riboflavin inhibits lipofuscin and prolongs lifespan in fruit flies
#1
Posted 30 April 2017 - 03:13 PM
#2
Posted 30 April 2017 - 04:01 PM
Inhibiting lipofuscin, glucosepane, and other waste products won't do much to reverse aging -- if anything at all. What we need are substances that can break these molecules so they can be removed from the body.
#3
Posted 30 April 2017 - 05:13 PM
I think there is already a method for the body to remove these things. It's proven already that significantly reducing lipoprotein(a) can reverse atherosclerosis. So where does the accumulated lpa go? Obviously the body can remove them.
#4
Posted 01 May 2017 - 03:14 AM
lipoprotein is not a cross linked protein; age breakers are needed to reverse glucosopane (the skin cross-links contributing to wrinkles).
#5
Posted 01 May 2017 - 02:15 PM
They always say that there is NO way to remove those things unless highly expensive pharmaceuticals are designed especially for this task (LOL) and it always proves to be false, that there is an endogenous way to remove these "toxins" and they accumulate for good reasons (take lipoprotein that repairs the arteries, take amyloid beta that is neuroprotective, etc.).
It is only very rarely that these "toxins" don't serve a purpose (like calcium in arteries)
#6
Posted 01 May 2017 - 02:20 PM
Why do misfolded proteins only accumulate when you reach your 40s and above? Why not in your 20s? 20 years is actually very old if you have any understanding of biology. Most animals don't live past around that age.
What about misfolded proteins caused by genetic mutations like marfan syndrome. Do you really think that even if you fixed the mutated gene or genes so the body was producing the right proteins, you'd still need to remove the old misfolded protein? That doesn't seem to be right.
#7
Posted 01 May 2017 - 07:46 PM
They always say that there is NO way to remove those things unless highly expensive pharmaceuticals are designed especially for this task (LOL) and it always proves to be false, that there is an endogenous way to remove these "toxins" and they accumulate for good reasons (take lipoprotein that repairs the arteries, take amyloid beta that is neuroprotective, etc.).
It is only very rarely that these "toxins" don't serve a purpose (like calcium in arteries)
If you know of a way to easily break down different forms of lipofuscin, glucosepane, and other types of AGE, you should contact SENS and let them know. They have been working on the problem for over a decade now.
Maybe contact the Speigel lab as well with your knowledge of inter and intracellular junk: http://www.longecity...pane-synthesis/ They are working very hard on a way to break down glucossepane.
Also tagged with one or more of these keywords: riboflavin, lipofuscin, lifespan, sod, catalase, vitamin b2
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