"Inhibitory Effects of Growth Differentiation Factor 11 on Phenotypic Transition Associated
with Autophagy Deficiency in Mouse Coronary Arterial Myocytes"
Abstract:
"
Growth-differentiation factor 11 (GDF11) as an anti-aging factor may reverse age-related cardiac
hypertrophy in mice and cause youthful regeneration of cardiomyocytes.
"
It is concluded that both exogenous and endogenous GDF11 promote CAMs differentiation and
prevent a phenotypic transition of these cells by reduction of lysosome
accumulation induced by different pathological stimuli.
"
http://www.fasebj.or...ent/826.1.short