154 replies to this topic

[WOG2021]

You can buy it here:

 

https://mitolab.com/...am-60m-120ml-2/

 

A specially formulated cream containing a 0.5uM concentration of methylene blue.

 

A recent study confirmed that Methylene Blue has the potential to slow down the skin’s natural aging process (R).

DermaBlue mitochondrial research cream uses Methylene Blue at a concentration of 0.5uM, in accordance with preliminary research on Methylene Blue as an anti-aging skin treatment.

Ingredients: Almond oil, Borax, Methylene Blue & Purified Water

 

[TheFountain]

This piqued my interest in MB

 

[Geijutsu]

Hi, I'm in agreement with others regarding concern about using MB in skin cream because of its photodynamic qualities...eg 600nm range peak absorption which is a potential problem in sunlight and definitely a no no with infrared therapy. I have used it orally for many years but avoid skin for that reason. Possible applications using the combo for fungal or bacterial infections but would not use as face cream.....unless I lived in Scotland!!!

Methylene blue, with an absorption maximum at 668 nmin visible light region, as shown in Figure 6, is usually used in mixed indicators or as a redox indicator. Hence, the amount of MB was measured quantitatively with the absorption of light at 668 nm.

Say what now?! I thought MB is a good adjunct to use with Red and Near Infrared light.

[Geijutsu]

Souldn't that intensify and potentiate the rejuvenating effects of 670nm red light in skin?

That’s what confuses me, for example there’s this paper that lauds both MB and NIR light for neuroprotection:
https://www.frontier...2015.00179/full

Albeit, they didn’t specify if it’s about combining the two together or not. I personally have contacted the Bluelene company and asked them about combing their MB serum with red/nir light and their response was that in low doses, MB actually helps neutralize some of the initial burst of ROS that form from irradiating the skin with red/nir light.

Edited by Geijutsu, 16 July 2023 - 09:53 PM.

[ta5]

This thread started in 2017. Did anyone keep using Methylene Blue topically? And have you seen any benefits?

 

This post by smithx says 1.6mg in 1L solution would be 5uM. That seems like a ridiculously low concentration to me considering the oral dose is often suggested to be 5-20mg per day. I'm always suspicious when I see a topical dose of anything is much lower than the oral dose. For most things, the topical dose is higher than the oral dose. The oral dose studied for COVID19 was 1mg/kg every 12 hours. Though, that was only for 12 days. In the Alzheimer's study linked below, they say "the recommended safe dose appears to be between 1 and 4 mg/kg". 

 

How high of a concentration could we use topically twice a day and not get any noticeable staining?

 

What do folks here think of the risks?:

 

National Toxicology Program. Toxicology and carcinogenesis studies of methylene blue trihydrate (Cas No. 7220-79-3) in F344/N rats and B6C3F1 mice (gavage studies).

Natl Toxicol Program Tech Rep Ser. 2008 May;(540):1-224. PMID: 18685714.

"The increased incidence of malignant lymphoma in males receiving 25 mg/kg may have been related to the administration of methylene blue trihydrate. There was equivocal evidence of carcinogenic activity in female B6C3F1 mice based on marginally increased incidences of malignant lymphoma."

 

This study references the above study:

Oz M, Lorke DE, Petroianu GA.

Methylene blue and Alzheimer's disease.

Biochem Pharmacol. 2009 Oct 15;78(8):927-32. doi: 10.1016/j.bcp.2009.04.034. Epub 2009 May 9. PMID: 19433072.

"In neonates, MB toxicities include hemolytic anemia, respiratory distress, and phototoxicity. The use of MB during pregnancy and intra-amniotic procedures is not recommended, due to its association with a high percentage of fetal intestinal atresia and other teratogenic effects [31]. The results of comprehensive studies by the National Toxicology Program [33] indicated that MB is mutagenic in several bacterial strains and that long term MB administration (1–24 months) in rodents is associated with lymphomas as well as various intestinal malignancies."