I simply haven't seen enough anecdotes to inspire me to buy FOXO4-DRI, although I have been looking for it with great personal bias.
If I am missing something please tell me the conversation number(s) so that I can read it(them).
Thank you.
I've gone through quickly and collected the anecdotal responses among all the irrelevant diversions in the thread (Note that I don't guarantee I haven't missed one) -
Meatsauce's initial results.
The bottom line is that Meatsauce (to my knowledge the only one so far to have taken it) has -- I think -- developed a mild case of gout, presumably from hyperuricemia caused by tumor lysis syndrome.
......
He initially didn't think it was related to the peptide, since apparently his bed sucks, which could explain the neck and back, and he lifts weights, so an ankle injury could have been from that. But after hashing this out with him in some detail, he's related the following facts: 1) this feels like the pain is coming from his joints themselves, not the surrounding muscle/tendons; 2) it's persisted a couple weeks, though is now subsiding; and 3) it's basically only present at night when he moves the affected joints around.
....
In any event, it looks like the peptide works.
Anonymous from the group by:
"Coincidentally, about a week after the experimental procedures, I noticed my constant nagging low back pain is gone, both moving and at rest. Thirty-year-old grinding noises and pain in my cervical spine from a martial arts injury is reduced about 90%. The twice-weekly headaches went with it. I'm a programmer, and the continuous dull ache in my right wrist, forearm and fingers that has been building for the past 15 years from mouse-usage RSI is also about 90% gone. I'm sleeping better, deeper; waking without the fatigue, stiffness, head and body aches that used to greet every sunrise. My lungs and sinuses are clear, clogged ears unblocked. Breathing deeply is much easier, and a gentle, stimulating pleasure again. A cough I've had most of a year is almost entirely gone."
chris1299
Did my 50mg this week, 20mg 4/1 then 30mg on 4/5. Experienced some redness and inflammation around injection site (sub-Q on stomach, left and right of navel), and pain which gradually went away over two days both times. Small lumps now at injection sites—not visible externally, but I can feel them beneath the skin. I was careful with sterility—used bacteriostatic water, needles fresh out of wrapping, clean environment. May have reconstituted with too little fluid.
Both times after injection I became ill with mild flu-like symptoms. Those have mostly subsided by now. Also have been experiencing nausea and constipation. Hard for me to tell if this is just correlation or not—for all I know I happened to get sick independently of the drugs this week. Hopefully more experimenters post, as more data is better and if these symptoms are reported by others perhaps causation can be established (or, better, falsified).
No positive changes to report, but that is to be expected given my age (31).
Gern
I am 60. I never really feel my age. I run and jump, and play with my Great Dane. A year ago I was lifting 220lbs. If I fall I just roll and spring back up. My point is I’m old, but not frail.
My first injection was Tuesday, 30 mg, sub-q, in my belly fat. It stung a little at first, then got worse. The worst of it was over after a day and a half. Not much of note except I slept little the next night but felt great the next day. That’s not unheard of for me, but uncommon. Also after 20 hours I had muscle soreness in my shoulders and arms, as if I had overworked them. Which I do occasionally do, but it couldn’t think of any cause.
My second injection was 30 mg intramuscular in my left shoulder. Again it was no worse than a flu shot at first, but within a couple hours got very sore and felt warm to the touch. I’m fairly conscious of my mental state and concentration, having been treated for semi-mild depression. My concentration seemed improved. I was able to work on proof reading and grammar checks in something I was writing for a good 12 hours without becoming foggy or suffering mental fatigue. Again very rare, but hard to say as wouldn’t have felt that way anyway.
My third injection was 40mg last night in right shoulder. Very sore this morning, as if I had a big bruise, but without any signs of bruising. Also stings some. I would describe it as more than just “some soreness.” I felt like crap when I got up this morning. Had a sore throat and aches. I have a habit of getting sick if I make big changes like go on a ketogeneic diet, so its possible, but it doesn’t really feel like I’m sick, just run down and too little water perhaps. It’s getting better as time goes by.
Not much else to report. I didn’t take any bio markers. I’m just not that organized. I’m generally reasonably healthy anyway. It seems like it’s too soon to draw any conclusions about effects. Though I would say, I suspect an improvement in concentration and mental acuity (I am picking up on things I didn’t before and able to see solutions more easily.) Even that is hard to say because seasonal mood changes could partially account for it.
Daredevil
Today I took 35mg split into two subQ injections, one on either side of the bellly. The injection sites, each with 50ml of saline, quickly became both hot and irritated, but not much worse than when I inject Epitalon, only it's more intense and persistant over several hours. I attached a photo of one of them so that you can see it's a visible reaction, but nothing too nasty for sure.
I was planning on upping my dose to 50mg and spreading treatment over 2 days, instead of the usual 3 injections, one every other day. However I noted an unexpected effect of this product. My body feels warm and flushed, with the impression of being worked on from the inside. While this may be an imaginary placebo effect, many other products I have taken even at high doses gave me no such sensations.
I notice something is going on, and it is sufficient that I believe that an effectiveness plateau is reached in my case at 35mg/80kg body weight. I plan to take my next two identical doses during the next two days, reducing the duration of my exposure by half, but increasing the circulating dose during these three days by approximately 50% when accounting for product half-life. I will not take any other products during this testing and will soon post further comments.
https://www.longecit...ndpost&p=848341
OK, here's the second follow-up. My first subQ injection was done in the afternoon, the second one upon wake-up the following morning. Each was dosed at 35mg. I was about to take the last dose the same day before bed, but felt it was still active enough to wait. I took the third dose of 30mg the following morning.
This last dose is still active so I cannot give my final conclusions this soon. However, in sum my impressions so far are as follow. Upon the first injection I noted a manifest effect. I hadn't heard positive responses from others so I was ready to add 15mg to my first dose an hour later, splitting the 100mg into two subsequent injections of 50mg each. However, I felt the effects were strong enough to not do this. Remember, I am notorious for upping dosage until I can really feel effects, so this attests to the fact that there is definitely, at least in my case, something going on at the 35mg dosage.
It is hard to describe something that affects your body in ways that you never experienced before. So I will try to outline a few of my impressions. At first I felt a warmth throughout my body and also a combination of slightly more low ebb energy as well as a sense of calm and relaxation. This was unexpected and lasted the entire first day. During the second day of intake I worked for ten hours and felt fine. One thing I noticed was first a sense of being more centered physically, i.e. a heightened awareness of my body but not so much of its outlying surface, and a tightening sensation that feels like a general contraction of all tissues. I don't know what this can be attributed to, hopefully it is due to the elimination of old cells that have less binding force or possibly the loss of cells in general that causes one's body to carry slightly less mass and occupy a bit less physical space?
The second morning after, prior to the third intake I felt like the effects had subsided, with maybe 25% residual effects as it was definitely wearing off. So I no longer postponed the third injection and took the remaining 30mg of Foxo4-DRI. I think it is probably more important to retain a sufficiently active amount of this chemical in one's bloodstream for it to do a more active cell clearing than would occur with lower dosages in circulation in your body. I find that at least in my case it is more worthwhile than using lesser dosages over a longer period of time. It's like hitting a nail with a hammer in my view, you can tap it gently for days without driving it in, while a single stronger blow can knock it into the board instantly.
While I understand that mechanical force and manifest effect of chemicals are not at all the same thing, I do see a similarity with their respective threshold factors wherein under sufficient impact the forces are resisted, and cannot reach the desired effect. I don't know whether the half-life of drugs in mice is different than in humans, but I think that possibly the best way to reproduce the test results that were published, would be to maintain this protocol for six days, but dosing every day instead of every other day might be more effective. It could be because the translation of dosages to our human levels is different, but if I had more I would definitely stretch this test further until 200mg had been injected. I don't feel in any way negatively affected, much to the contrary.
I will report back on my impressions of my third daily dose, and speaking of what I may have noted as the general effects of this treatment prior to follow-up with a short run of Dasatinib and Quercetin that I should start a few days later. Afterwards I plan to do cell sweeping and clearance and through chelation with EDTA and wheatgrass. This prior to preparing with supplements and preliminary treatments for my second activated autologous bone marrow stem cell infusion.
So I will resume with my concluding remarks about my last day of intake at 30mg subQ. Interestingly I felt less residual effects the morning after than subsequently to the first intake. I sensed I had maybe 15% left in my body before the last shot, and therefore was happy that I had a remedial dose left to take. Once I injected it subQ I happily noticed that within an hour or two it has re-become active at a similar level to the previous day. I also felt that this was furthering its effect and that my body was feeling somehow rearranged and tensed up.
tintinet
https://www.longecit...ndpost&p=848411
Amazing. Did nada for me.
stponky
https://www.longecit...ndpost&p=848595
Some observations:
1) It took way longer for my calf muscles to recover. Usually around 3 days but in this case about a week.
2) I usually don't get enough sleep (6 1/2 - 7 hours) so I wonder if my strong sleep reaction was FOXO4 DRI working on my brain.
3) My hip feels better but I still feel the tendon issue. The FOXO4 DRI did help my joint discomfort. I hope it stays better as I continue to go through the summer.
4) When I drive, I notice that a slight discomfort in my heart when I stop the car more suddenly. Driving in rush hour is also stressful. I have not noticed this after FOXO4. I have been worried in the back of my mind that something was going wrong with my heart. I am hoping that it remains ok.
If I were to do it again:
1) I would try to eat less to stress the cells. I didn't really fast at all.
2) I would do things that stress areas that I want FOXO4 to attack. Ex., if your wrist is bad try stressing the wrist a little to send signals to FOXO4 to clear things out there.
3) Take metformin (or maybe something else is better) throughout for more stress.
Overall, I would say it has been positive. I would be willing to try it again.
Out of the 7 responses - 1 (tintinet) didn't notice any differences but didn't really provide any other info, the posters in the 30 - 40 age range didn't appear to notice any big permanent changes (at least at the time of posting) other than effects for a few days after they injected, and the older individuals noticed the biggest improvements.
Basically what you'd expect - with the 30 - 40 year old's possibly benefiting from the injection from a much more longer term view in potentially slowing down the effects of aging.
Edited by Ibbz, 11 September 2018 - 02:23 AM.
