848 replies to this topic

[RenewYou]

Mi Meatsauce

 

Do you find cjc 1295 to be more effective than the oral MK677? I had the exact same protocol in mid as you described above,  (perhaps with a little TB500 added in for good measure), but would love to know your opinion on the 2 GH secretagogues as I've only experimented w/ MK766 (with great success)

 

And yes I'd like in on the next Group Buy

 

Cheers

 

[RenewYou]

 

 

Hope I made it into the first group buy. If it matters i will do pre and post blood tests. The only things I will be on is megadosing liposomal resveratrol, cjc and bpc for the next 5 weeks.

I know it's off topic, but what are those (aside from the resveratrol) and why are you megadosing them?

 

cjc 1295 is a peptide that causes a the pituitary gland to constantly release growth hormone which will cause an increase in IGF1. BPC - 157 is another peptide that is produced in the stomach that was found to have systemic healing effects when injected. 

 

 

Mi Meatsauce

 

Do you find cjc 1295 to be more effective than the oral MK677? I had the exact same protocol in mid as you described above,  (perhaps with a little TB500 added in for good measure), but would love to know your opinion on the 2 GH secretagogues as I've only experimented w/ MK766 (with great success)

 

And yes I'd like in on the next Group Buy

 

Cheers

[framework7]

Hello,

I am interested in any subsequent cycle of this group buy, for at least 100mg and possibly more.

I am also available to fill any gap in the current group buy, in case anyone pulls out or is unable to coordinate payment and logistics.

Also, just curious-- are you acetylating the N-terminal or amidating the C-terminal of this peptide, or just using free acids at the termini?  It could be more stable and membrane-permeant with these modifications, but the original documents and Cell paper associated with FOXO4-DRI do not do so.

Anyway, nice to be here.  Please keep me in mind.  Please keep me in mind likewise for other group buys in general, as there are various other compounds that interest me as well.

[extendcel]

Hello,

I am interested in any subsequent cycle of this group buy, for at least 100mg and possibly more.

I am also available to fill any gap in the current group buy, in case anyone pulls out or is unable to coordinate payment and logistics.

Also, just curious-- are you acetylating the N-terminal or amidating the C-terminal of this peptide, or just using free acids at the termini? It could be more stable and membrane-permeant with these modifications, but the original documents and Cell paper associated with FOXO4-DRI do not do so.

Anyway, nice to be here. Please keep me in mind. Please keep me in mind likewise for other group buys in general, as there are various other compounds that interest me as well.

The D retro inverso sequence itself solves any stability issues with this peptide. It's best not to detract from the literature this early into the game.

[framework7]

The D retro inverso sequence itself solves any stability issues with this peptide.

Certainly true endogenously -- more resistant to proteases.

I was more curious about stability in solution, but I suppose the dosing protocol is a relatively quick succession based on my reading of the de Keizer interview.  Should be ok if the reconstituted solution is kept a few degrees above freezing between uses.
 

It's best not to detract from the literature this early into the game.

Of course.  Just checking the exact details.  I agree this is the best approach at present.

Edited by framework7, 10 January 2018 - 08:05 AM.

[Vantika]

Hey, guys.

 

I wanted to let everyone know that I just got my FOXO4-DRI from meatsauce from the first batch.

 

Everything looks good. Purity came out higher than ordered/expected (98.5% purity was achieved, even though we only paid for 95%).

 

Hopefully the next batches should be arriving pretty soon! 

 

At this point, you might want to think about reserving a little bit of freezer space to store yours.

 

Most peptide handling documents I've read recommend storing your freeze-dried peptides at -20°C (-4°F) for medium-term storage (anything longer than a couple weeks), which supposedly will confer stability from somewhere between two months to a year, depending on the source of the instructions.  My freezer reaches this temperature (-20°C / -4°F) at its coldest setting, so something near this temperature ostensibly is achievable with a normal, household freezer.

 

Each 10 mg vial is about the same diameter as a tube of chapstick, though only about half the length.  Divide the amount of peptide you ordered by 10 mg and that's how many vials of this size you'll need space for, until you're ready to use it.  Mine actually ended up taking far less space than I originally expected (the vials being pretty small).

 

 

[extendcel]

 

The D retro inverso sequence itself solves any stability issues with this peptide.

Certainly true endogenously -- more resistant to proteases.

I was more curious about stability in solution, but I suppose the dosing protocol is a relatively quick succession based on my reading of the de Keizer interview.  Should be ok if the reconstituted solution is kept a few degrees above freezing between uses.
 

It's best not to detract from the literature this early into the game.

Of course.  Just checking the exact details.  I agree this is the best approach at present.

 

 

Yes, reconstituted peptides must be stored in the fridge, not the freezer or room temperature. From my experience with peptides, they are a lot more stable than we give them credit for. Even reconstituted HGH will remain viable for a few weeks in the fridge. I've had shorter peptides (reconstituted) stored for months that were still quite potent.

 

FOXO4DRI would be used up before it would degrade significantly.
 

Edited by extendcel, 11 January 2018 - 07:25 AM.

[meatsauce]

Im going to have the order size increased for those who want this peptide for their anti-aging research. PM me for details

 

Edited by meatsauce, 11 January 2018 - 05:09 PM.

[Moondancer]

Will the same supplier be used for the second group buy?

[meatsauce]

Will the same supplier be used for the second group buy?

Yes they are speeding up now.

[helix66]

 

 

The D retro inverso sequence itself solves any stability issues with this peptide.

Certainly true endogenously -- more resistant to proteases.

I was more curious about stability in solution, but I suppose the dosing protocol is a relatively quick succession based on my reading of the de Keizer interview.  Should be ok if the reconstituted solution is kept a few degrees above freezing between uses.
 

It's best not to detract from the literature this early into the game.

Of course.  Just checking the exact details.  I agree this is the best approach at present.

 

 

Yes, reconstituted peptides must be stored in the fridge, not the freezer or room temperature. From my experience with peptides, they are a lot more stable than we give them credit for. Even reconstituted HGH will remain viable for a few weeks in the fridge. I've had shorter peptides (reconstituted) stored for months that were still quite potent.

 

FOXO4DRI would be used up before it would degrade significantly.
 

 

 

Could the FOXO4DRI peptide be transported at essentially room temperature for a period of approximately 7 days, or does it necessitate packing in dry ice? Would there be significant stability issues (at room temperature)? This is for a batch to be air freighted to Australia.

Edited by helix66, 16 January 2018 - 03:38 PM.

[extendcel]

The D retro inverso sequence itself solves any stability issues with this peptide.

Certainly true endogenously -- more resistant to proteases.

I was more curious about stability in solution, but I suppose the dosing protocol is a relatively quick succession based on my reading of the de Keizer interview. Should be ok if the reconstituted solution is kept a few degrees above freezing between uses.

It's best not to detract from the literature this early into the game.

Of course. Just checking the exact details. I agree this is the best approach at present.

Yes, reconstituted peptides must be stored in the fridge, not the freezer or room temperature. From my experience with peptides, they are a lot more stable than we give them credit for. Even reconstituted HGH will remain viable for a few weeks in the fridge. I've had shorter peptides (reconstituted) stored for months that were still quite potent.

FOXO4DRI would be used up before it would degrade significantly.

Could the FOXO4DRI peptide be transported at essentially room temperature for a period of approximately 7 days, or does it necessitate packing in dry ice? Would there be significant stability issues (at room temperature)? This is for a batch to be air freighted to Australia.

Shouldn't be an issue if it's lyophilized if it's actually at room temperature, but there's always room for issue in the summer heat. I would personally have it packed in some type of insulation to be safe. I've heard Australian customs is pretty strict on peptides though. Are you sure they won't seize it?

[Moondancer]

This has been asked but how do we know for sure the Foxo4-d-retro-inverso peptide we are ordering/using is really similar to the peptide used in the studies. It doesn't seem like a too easy peptide to produce, and the fact it took the company so long to produce it actually shows that too. Why don't we order from Pepscan in the first place as they provided the peptide used in the studies? What company are we ordering from currently? 

Edited by Moondancer, 16 January 2018 - 05:15 PM.

[meatsauce]

This has been asked but how do we know for sure the Foxo4-d-retro-inverso peptide we are ordering/using is really similar to the peptide used in the studies. It doesn't seem like a too easy peptide to produce, and the fact it took the company so long to produce it actually shows that too. Why don't we order from Pepscan in the first place as they provided the peptide used in the studies? What company are we ordering from currently? 

Its not a good idea to post that info publicly but peptide companies verify the peptide with MS along the way.  Pepscan happened to be the peptide manufacture that the inventors chose to make the peptide. They could have picked someone else to make it and we would be talking about a different company. Pepscan is also much more expensive. 

[Nate-2004]

Looking forward to hearing results. Take note and let us know what dosage, frequency and method you used, I assume injection. Please take before/after pics in same scene same lighting conditions. Get blood work before/after if possible. Write down how you feel in general before then after. Etc.

[helix66]

extendcel

 

Shouldn't be an issue if it's lyophilized if it's actually at room temperature, but there's always room for issue in the summer heat. I would personally have it packed in some type of insulation to be safe. I've heard Australian customs is pretty strict on peptides though. Are you sure they won't seize it?

 

 

In regards to importing it into Australia, I checked, the peptide doesn't meet any restrictions (as far as I can determine);

 

* It's not on the Importation of controlled substances list; https://www.odc.gov.au/importers

 

* It meets the TGA - Importation of Therapeutic Goods for Personal Use. https://www.tga.gov....l-import-scheme

 

Looks like I need to make a stat dec in regards to 3 months supply; http://www.agricultu...c-foods-dietary

 

I'm currently seeking contact with the TGA for final confirmation.

 

In short as long as it's for personal importation, less than 3 months supply, not on a restricted list, and doesn't fall into the following; 

* anabolic substances

* androgenic steroids

* treatments for alcohol and drug addiction

* erythropoietin

* darbepoietin alfa

* growth hormones

* gonadotrophins

* antibiotics

It's permitted for personal importation.

 

Link to personal import guidelines; https://www.tga.gov....-guidelines.pdf

 

[smithx]

extendcel
 In regards to importing it into Australia, I checked, the peptide doesn't meet any restrictions (as far as I can determine);

It could be easier to just not say anything about it. By admitting it has a medical intention you may be opening yourself up to having to prove that it's OK rather than not having to prove anything.

[Moondancer]

 

extendcel
 In regards to importing it into Australia, I checked, the peptide doesn't meet any restrictions (as far as I can determine);

It could be easier to just not say anything about it. By admitting it has a medical intention you may be opening yourself up to having to prove that it's OK rather than not having to prove anything.

 

 

How would you advise shipping it overseas? And with a specific carrier?

[extendcel]

I bring this concern up because I've heard many stories of Australian customs seizing popular bodybuilding peptides like ghrps and ghrhs. Since they've banned these peptides then they may put all peptides in general under scrutiny. Getting this foxo4dri seized may be expensive.

Edited by extendcel, 17 January 2018 - 09:42 PM.

[helix66]

I bring this concern up because I've heard many stories of Australian customs seizing popular bodybuilding peptides like ghrps and ghrhs. Since they've banned these peptides then they may put all peptides in general under scrutiny. Getting this foxo4dri seized may be expensive.

 

Yes if anyone has any alternate suggestions for labeling packing to Aus please speak up.

 

FYI - I was redirected by TGA to email The Office of Drug Control and I'm fearful this might trigger FOXO4 being added to the list rather than being approved.

[Zed]

 

I bring this concern up because I've heard many stories of Australian customs seizing popular bodybuilding peptides like ghrps and ghrhs. Since they've banned these peptides then they may put all peptides in general under scrutiny. Getting this foxo4dri seized may be expensive.

 

Yes if anyone has any alternate suggestions for labeling packing to Aus please speak up.

 

FYI - I was redirected by TGA to email The Office of Drug Control and I'm fearful this might trigger FOXO4 being added to the list rather than being approved.

 

 

I would just use stealth packaging and express DHL.

I have had tons of RC's, Peps and SARMs come through - generally all posted in a small envelope US Mail marked innocuously. Its the luck of the draw.  SARMS are likely to get through as they are not androgenic whereas steroids are a no no.( damn I even had mild Testogel confiscated off me coming back to OZ even though I had bought it in OZ before leaving and had the RX with me. Apparently needed a permit prior). The law really sucks.

 

Given the TGA has just banned Phenibut (WTF!? whats next? Green tea? ) and apparently also Phenlypiracetam   I wouldnt be prodding them for a permit - it will just trigger an expansion of their nanny list....imo.

 

[JJet]

Bit offtopic sorry but the other Foxo4-d-retro-inverso-topic seems dead. Could a senolytic agent such as Foxo4-d-retro potentially be effective in reducing fibrotic scar tissue?

[helix66]

 

 

I bring this concern up because I've heard many stories of Australian customs seizing popular bodybuilding peptides like ghrps and ghrhs. Since they've banned these peptides then they may put all peptides in general under scrutiny. Getting this foxo4dri seized may be expensive.

 

Yes if anyone has any alternate suggestions for labeling packing to Aus please speak up.

 

FYI - I was redirected by TGA to email The Office of Drug Control and I'm fearful this might trigger FOXO4 being added to the list rather than being approved.

 

 

I would just use stealth packaging and express DHL.

I have had tons of RC's, Peps and SARMs come through - generally all posted in a small envelope US Mail marked innocuously. Its the luck of the draw.  SARMS are likely to get through as they are not androgenic whereas steroids are a no no.( damn I even had mild Testogel confiscated off me coming back to OZ even though I had bought it in OZ before leaving and had the RX with me. Apparently needed a permit prior). The law really sucks.

 

Given the TGA has just banned Phenibut (WTF!? whats next? Green tea? ) and apparently also Phenlypiracetam   I wouldnt be prodding them for a permit - it will just trigger an expansion of their nanny list....imo.

 

 

Cheers thanks for your feedback.

 

Few questions, probably a bit naive, when you say stealth packaging, do you mean not listing what is inside the package or listing it as some other item. If the later what do you recommend listing it as?

 

Secondly, seeing as the FOXO4 is in vial format would you use a box for the express DHL package?

 

Once again cheers for your input.
 

[extendcel]

I bring this concern up because I've heard many stories of Australian customs seizing popular bodybuilding peptides like ghrps and ghrhs. Since they've banned these peptides then they may put all peptides in general under scrutiny. Getting this foxo4dri seized may be expensive.

Yes if anyone has any alternate suggestions for labeling packing to Aus please speak up.

FYI - I was redirected by TGA to email The Office of Drug Control and I'm fearful this might trigger FOXO4 being added to the list rather than being approved.

I would just use stealth packaging and express DHL.
I have had tons of RC's, Peps and SARMs come through - generally all posted in a small envelope US Mail marked innocuously. Its the luck of the draw. SARMS are likely to get through as they are not androgenic whereas steroids are a no no.( damn I even had mild Testogel confiscated off me coming back to OZ even though I had bought it in OZ before leaving and had the RX with me. Apparently needed a permit prior). The law really sucks.

Given the TGA has just banned Phenibut (WTF!? whats next? Green tea? ) and apparently also Phenlypiracetam I wouldnt be prodding them for a permit - it will just trigger an expansion of their nanny list....imo.

Cheers thanks for your feedback.

Few questions, probably a bit naive, when you say stealth packaging, do you mean not listing what is inside the package or listing it as some other item. If the later what do you recommend listing it as?

Secondly, seeing as the FOXO4 is in vial format would you use a box for the express DHL package?

Once again cheers for your input.

Stealth packaging is often packing some inconspicuous object and labeling it based on the inconspicuous object. Then you would attempt to blend or hide the object in the package. Of course if they find the peptides in this case it's definitely getting seized regardless of its importation status.

[Moondancer]

Out of curiosity: has the first batch been shipped? How many group members have started using the peptide already? When is the second batch expected? Can't deny I can't wait for updates. 

[meatsauce]

Out of curiosity: has the first batch been shipped? How many group members have started using the peptide already? When is the second batch expected? Can't deny I can't wait for updates. 

  The first part of the first order went out to a few people. The majority of the rest of the first order is almost finished. I think Im the fist one to complete a cycle. We figured out the best way to use the peptide and will will PM everyone who ordered instructions. 

Edited by meatsauce, 21 January 2018 - 11:59 PM.

[tintinet]

No soup for me, yet!

[Zed]

 

 

 

I bring this concern up because I've heard many stories of Australian customs seizing popular bodybuilding peptides like ghrps and ghrhs. Since they've banned these peptides then they may put all peptides in general under scrutiny. Getting this foxo4dri seized may be expensive.

 

Yes if anyone has any alternate suggestions for labeling packing to Aus please speak up.

 

FYI - I was redirected by TGA to email The Office of Drug Control and I'm fearful this might trigger FOXO4 being added to the list rather than being approved.

 

 

I would just use stealth packaging and express DHL.

I have had tons of RC's, Peps and SARMs come through - generally all posted in a small envelope US Mail marked innocuously. Its the luck of the draw.  SARMS are likely to get through as they are not androgenic whereas steroids are a no no.( damn I even had mild Testogel confiscated off me coming back to OZ even though I had bought it in OZ before leaving and had the RX with me. Apparently needed a permit prior). The law really sucks.

 

Given the TGA has just banned Phenibut (WTF!? whats next? Green tea? ) and apparently also Phenlypiracetam   I wouldnt be prodding them for a permit - it will just trigger an expansion of their nanny list....imo.

 

 

Cheers thanks for your feedback.

 

Few questions, probably a bit naive, when you say stealth packaging, do you mean not listing what is inside the package or listing it as some other item. If the later what do you recommend listing it as?

 

Secondly, seeing as the FOXO4 is in vial format would you use a box for the express DHL package?

 

Once again cheers for your input.
 

 

 

Stealth as in "reasonable deniability" . You dont want to mislabel something (eg call it "childs doll" )  as that could be a red flag. However you can use vague or tangential references .."ie Beauty Product "  or as is normally put on the numerous vials of RC's and peps I have received -"MS samples"  - whatever that is.

 

I have received literally over a dozen peps in vials posted in plain US express post envelopes  wrapped in bubble warp plastic - no sweat (US $13.50) - 10 working days with online tracking . Being in an envelope may even help being waved through.

 

I suggested Fed Ex Box (3-4 days) as I thought you needed an ice pack or something -if not express envelope is fine.

 

A friend getting similar RC's - boldly marked "Research Chemical - Not for Human Consumption" had her package opened by the Customs - and a letter to that effect inserted but all good - no warnings, questions whatever. I guess its the luck of the draw - if its a chemical that comes up on their radar then they will throw the book at you - otherwise not.

PS -I generally make a small animal sacrifice to Mercury the messenger of the Gods every time I order a package - seems to work.. 

 
 

[Orinoco]

Have followed this topic as an interested lurker for a while and signed up for it. I'd be interested to buy 400-500mg Foxo4-D-retro-inverso peptide. But: how do we get any insight in the quality? 

 

I contacted the Chinese supplier mentioned in this topic and they gave me exactly the same timing, as the Foxo-order in this topic. Does this order come from China, or does it come from GenScript as was mentioned a few pages back in this topic?

MeatSauce, this is not to question your motives since it is generous of you to spend your time on this. But I've been fooled all too often blindly trusting people (even close friends). And this is a decent investment so personally I'd want to have more information before I'd do such an investment. As said, to trust someone blindly didn't bring me far in the past. You seem to be involved in several group buys: I just saw you offered spermidine in a topic on here asking if others wanted to buy through you, Tiron, Epitalon to name a few. Is this a business for you? It would be only fair to me if the person that arranges the group buy would make some money from it: it takes time of course. But I'd want to have an idea of who I am paying to, whether this person is selling peptides as a business, and where the peptide comes from. I can't be the only one that is wondering?

[meatsauce]

Have followed this topic as an interested lurker for a while and signed up for it. I'd be interested to buy 400-500mg Foxo4-D-retro-inverso peptide. But: how do we get any insight in the quality? 

 

I contacted the Chinese supplier mentioned in this topic and they gave me exactly the same timing, as the Foxo-order in this topic. Does this order come from China, or does it come from GenScript as was mentioned a few pages back in this topic?

MeatSauce, this is not to question your motives since it is generous of you to spend your time on this. But I've been fooled all too often blindly trusting people (even close friends). And this is a decent investment so personally I'd want to have more information before I'd do such an investment. As said, to trust someone blindly didn't bring me far in the past. You seem to be involved in several group buys: I just saw you offered spermidine in a topic on here asking if others wanted to buy through you, Tiron, Epitalon to name a few. Is this a business for you? It would be only fair to me if the person that arranges the group buy would make some money from it: it takes time of course. But I'd want to have an idea of who I am paying to, whether this person is selling peptides as a business, and where the peptide comes from. I can't be the only one that is wondering?

GS is a Chinese company with an office in the US.  This is more of a hobby for me right now as I am really into anti aging and I am doing these group buys as a way to acquire hard to get anti-aging compounds for cheap. I do have plans to start a peptide business that offers the best third party tested peptides as the quality of most peptides from online stores is not verified. I just need a lot of capitol to get everything that I want to offer. The only current group buys I'm doing are this one and the epitalon one.  

 

The peptides are verified with mass spectrometry and high pressure liquid chromatography which I have crossed referenced from other companies who have made the same peptide. 

 

Edited by meatsauce, 24 January 2018 - 06:33 PM.