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Nigella sativa (thymoquinone) as an HDACi

hdac hdaci vorinostat emdr fear extinction

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#1 StabMe

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Posted 08 June 2017 - 03:47 PM


Hey!

 

It has been speculated, that main ingredient in Nigella Sativa - Thymoquinone - posses some HDAC inhibiting activity. Musicman4534, the guy who organized Vorinostat group buy, alluded to this in the group buy thread. 

 

I was wondering, is it possible to calculate the amount of the ingredient needed to induce an inhibition required for, say, an EMDR session? Fear extinction session? A learning session of any other kind? I could buy it in seeds form, or as an extract. 

 

It is very hard to find a pharmaceutical version on HDACi for me, given my location. So kinda looking for an alternative. Really interested in trying the compound alongside EMDR, Neurofeedback, skills learning, etc.

 

There is a thread of a guy who used tributyrin with EMDR therapy sessions who reports tremendous success. The problem is that i couldn't source any Tributyrin either.

 

So, any thoughts and speculations are welcome.



#2 William Sterog

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Posted 09 June 2017 - 01:51 PM

What about supplementing broccoli sprouts? 

 

https://www.ncbi.nlm...les/PMC2777483/

 

https://www.ncbi.nlm...les/PMC2561129/

 

 


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#3 normalizing

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Posted 14 June 2017 - 07:44 PM

what does HDAC inhibition means?


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