3 replies to this topic

[Snejks]

Welcome, someone know thats true high protein and high carb diet short life?
What macros(Prot./Carb./Fat) proportions are very good for healthy man?

[ekaitz]

I always liked the 50/30/20 carb/fat/protein.

Edited by ekaitz, 22 June 2017 - 10:33 PM.

[mccoy]

There are so many theories and experiments but little facts on humans.

 

On lab mice the literature suggests that a very high carb diet with little protein (C/P ratio = 10) increases longevity.

In humans, in the longevity-prone blue zone areas people tend to eat  prevalently carbs, with fats and protein subordinate. healthy food, like vegetables, natural starch, fruit, nuts & seeds, little animal protein, usually

 

 

Ageing Res Rev. 2017 Mar 6. pii: S1568-1637(17)30046-6. doi: 10.1016/j.arr.2017.03.001. [Epub ahead of print]

Dietary protein, aging and nutritional geometry.

Simpson SJ1, Le Couteur DG2, Raubenheimer D3, Solon-Biet SM4, Cooney GJ4, Cogger VC2, Fontana L5.

 

 

[Darryl]

Little experimental evidence in humans, but the animal studies are very consistent: protein restriction extends lifespan. And in humans, higher protein intake, at least from high methionine animal sources, increases cardiometabolic risk and all-cause mortality among the middle aged. As you'll note from the refs below, its a lively topic of research of late, particularly at the Charles Perkins Centre, University of Sydney, and in Valter Longo's lab at USC Leonard Davis School of Gerontology.

 

Given true protein and or methionine restriction is not particularly practical for the weak-willed like myself, I aim for protein and methionine moderation, a high ratio of (glycine+serine)/(methionine+cysteine) (ie, legumes/nuts for protein), and periodic fasts. The animal evidence makes a compelling case that caloric restriction practitioners that achieve satiety through high protein diets may be undermining the benefits.

 

Recent studies/reviews focusing on animal protein restriction experiments:

 

Sanz et al, 2004. Protein restriction without strong caloric restriction decreases mitochondrial oxygen radical production and oxidative DNA damage in rat liver. Journal of bioenergetics and biomembranes, 36(6), pp.545-552.

Nakagawa et al, 2012. Comparative and meta‐analytic insights into life extension via dietary restriction. Aging cell, 11(3), pp.401-409.

Mirzael et al., 2014. Protein and amino acid restriction, aging and disease: from yeast to humans. Trends in Endocrinology & Metabolism, 25(11), pp.558-566.

Solon-Biet et al, 2014. The ratio of macronutrients, not caloric intake, dictates cardiometabolic health, aging, and longevity in ad libitum-fed mice. Cell metabolism, 19(3), pp.418-430.

Solon-Biet et al, 2015. Dietary protein to carbohydrate ratio and caloric restriction: comparing metabolic outcomes in mice. Cell reports, 11(10), pp.1529-1534.

Shim and Longo, 2015. A protein restriction-dependent sulfur code for longevity. Cell, 160(1), pp.15-17.

Simpson et al, 2015. Putting the balance back in diet. Cell, 161(1), pp.18-23.

Mirzaei et al, 2016. The conserved role of protein restriction in aging and disease. Current opinion in clinical nutrition and metabolic care, 19(1), pp.74-79.

Le Couteur et al, 2016. The impact of low-protein high-carbohydrate diets on aging and lifespan. Cell Mol Life Sci, 73(6), pp.1237-52.

Le Couteur et al, 2016. Dietary protein, ageing and the Okinawan ratio. Age and ageing, 45(4), pp.443-447.

Díaz-Rúa,et al 2017. Long-term intake of a high-protein diet increases liver triacylglycerol deposition pathways and hepatic signs of injury in rats. The Journal of Nutritional Biochemistry, 46, pp.39-48.

 

I'll skip the methionine restriction experiments/reviews, as I'd be here all night.

 

Recent human epidemiology favoring lower protein intake:

Virtanen et al, 2006. High dietary methionine intake increases the risk of acute coronary events in middle-aged men. Nutrition, metabolism and cardiovascular diseases, 16(2), pp.113-120.

Halbesma et al, 2009. High protein intake associates with cardiovascular events but not with loss of renal function. Journal of the American Society of Nephrology, 20(8), pp.1797-1804.

Levine et al, 2014. Low protein intake is associated with a major reduction in IGF-1, cancer, and overall mortality in the 65 and younger but not older population. Cell metabolism, 19(3), pp.407-417.

 

Hernández-Alonso et al, 2016. High dietary protein intake is associated with an increased body weight and total death risk. Clinical Nutrition, 35(2), pp.496-506.

Malik et al, 2016. Dietary protein intake and risk of type 2 diabetes in US men and women. American journal of epidemiology, 183(8), pp.715-728.

Song et al, 2016. Association of animal and plant protein intake with all-cause and cause-specific mortality. JAMA internal medicine, 176(10), pp.1453-1463.

Xu et al, 2016. Excess protein intake relative to fiber and cardiovascular events in elderly men with chronic kidney disease. Nutrition, Metabolism and Cardiovascular Diseases, 26(7), pp.597-602.

Shang et al, 2016. Dietary protein from different food sources, incident metabolic syndrome and changes in its components: An 11-year longitudinal study in healthy community-dwelling adults. Clinical Nutrition.

Shang,et al, 2016. Dietary protein intake and risk of type 2 diabetes: results from the Melbourne Collaborative Cohort Study and a meta-analysis of prospective studies. The American journal of clinical nutrition, p.ajcn140954.

Azemati et al, 2017. Animal protein intake is associated with insulin resistance in Adventist Health Study-2 (AHS-2) calibration participants: A cross-sectional analysis. Current Developments in Nutrition, pp.cdn-116.