435 replies to this topic

[Mind]

This might have been posted earlier, but could someone please point to any human CD research? I know of the cat research  - treating Niemenns Pick disease, but what about human research?

[DougClean]

I posted a Link on a 6 year study on treating Niemenns Pick disease on humans.

That's all I could find.

 

Read all of it...2 people did have some hearing loss but they were dosing very high and the hearing loss was small.

looks like if you stay under 3-6G per dose its safe.

 

The AU guys used a 6 gram IV dose twice a day and said they had no side effects.

 

I did notice that the NPD Doctors changed the dosing to once a week with a at home IV kit.

They were hitting them once every 2 weeks with a stronger dose before.

 

6 year study on NPD

https://ojrd.biomedc...019-1207-1#Fig1

 

After almost a year of research  it looks like Cyclodextrin helps with

 

Niemenns Pick

COPD 

Aatherosclerosis

Alzheimers.

 

I started taking some CD today a very small dose will let people know how I feel in a few weeks.

Going to build up to 3-4g a day 4-5 times a week.

 

PS: Going to try and get a calcium score done in the next week or so

I want some proof that this stuff works or not.

 

 

 

 

[DougClean]

Hi guys just checking in..

 

Took about 40 Grams of CD over the last 3-4 weeks

At first no side effects at all but last week I started to get some inflammation on some of my plugged arteries (very small ones)

I know this because I took some EDTA months ago and had the same problem.

 

So for now I am off for a few weeks and will restart along with some strong anti-inflammatories.

 

The good news is we now know that the CD is getting to where its needs to be but removing plaque may cause some inflammation.

Next try will include 3 different anti-inflammatories in the hopes of stopping the inflammation before it gets bad.

Take care

[Snapper]

Would it be possible to improve the oral bioavailability by dissolving cyclodextrin in DMSO and drinking it?  Or taking it alongside MSM?

 

Also, any further progress reports from those taking it?  Always good to hear anything encouraging.

Edited by Snapper, 08 May 2022 - 01:08 PM.

[Wookie]

Would it be possible to improve the oral bioavailability by dissolving cyclodextrin in DMSO and drinking it? Or taking it alongside MSM?

Also, any further progress reports from those taking it? Always good to hear anything encouraging.

The tubes work very well. Cleaned out my carotid artery completely via doppler scan. Also no more angina. There's a USA website now. Cavadexusa.com
I take a tube in the morning and 1 at night. I took 6 boxes total then had my scan done.

[FrankEd]

You used 6 boxes that means US$ 1,350,00. Is that correct? Assuming each box has 32 tubes?

[Wookie]

You used 6 boxes that means US$ 1,350,00. Is that correct? Assuming each box has 32 tubes?

Correct. I do once a day now. I like to go out to eat so I'm going to continue dosing for the foreseeable future.

Yes correct.

[Mind]

Correct. I do once a day now. I like to go out to eat so I'm going to continue dosing for the foreseeable future.

Yes correct.

 

If the tubes made you better, why would you continue to use them? People don't continue taking chemotherapy after their cancer is gone.

[Wookie]

If the tubes made you better, why would you continue to use them? People don't continue taking chemotherapy after their cancer is gone.

I mean you're right I wouldn't keep taking chemo but this is a non toxic sugar that allows me to eat fatty foods without consequences. I mean I also take a multi vitamin and elderberry. I guess I just can't see a downside to taking it.

[Kevinsan]

We are all just concerned about hearing loss - Ototoxicity.

 

https://www.frontier...2017.00355/full

[Snapper]

The tubes work very well. Cleaned out my carotid artery completely via doppler scan. Also no more angina. There's a USA website now. Cavadexusa.com
I take a tube in the morning and 1 at night. I took 6 boxes total then had my scan done.

 

Thank you, good to hear this.  When there are many touted theories and supplements for atherosclerosis, to have something which you can take and find does work for you is terrific. 
 

[smithx]

Correct. I do once a day now. I like to go out to eat so I'm going to continue dosing for the foreseeable future.

Yes correct.

 

There's a good chance that the cyclodextrins you're taking are also attacking cell membranes of healthy cells. It's really best to stop while you're ahead and maybe repeat later if it becomes necessary.

 

Too much of a good thing can become a very bad thing indeed. I refer you to this sad story:

https://commonplacef...s-jaw-fell-off/

[eigenber]

Wondering why  Cavadex uses beta instead of gamma cyclodextrin when gamma is more absorbable?

[Kevinsan]

[TheFountain]

There's a good chance that the cyclodextrins you're taking are also attacking cell membranes of healthy cells. It's really best to stop while you're ahead and maybe repeat later if it becomes necessary.

 

Too much of a good thing can become a very bad thing indeed. I refer you to this sad story:

https://commonplacef...s-jaw-fell-off/

 

This

 

Using a compound as an excuse to have a shitty diet is an absolute no go. 

[Grooovin1]

Hello all, found this thread on a Google search and have been looking for people who have experience with this substance.

 

I have been using (2-Hydroxyproppyl)-beta cyclodextrin (I will be calling this HPBCD in my post from now on for obvious reasons) in parenteral delivery for about 6 months now. The results have kept me going. I will tell you what has happened with a regimen that has amassed approximately 2400 grams being delivered over a period of 6 months. 

I am a AA man age 54 who has 3 factors that result in the increased formation of arterial plaque namely: Cigarettes , medication and a really bad cocaine habit back in my 30s. My first problem was Erectile Dysfunction. Later I exhibited symptoms of Reynauds Syndrome, then my blood pressure was elevated to 130, also I was starting to have periodic symptoms of BPA (enlarged prostate).

So I started off 8 months ago trying to read everything I could about helping myself with the substance...luckily nothing went wrong as I turned out in my confusion using a combination of mainly HPBCD but with smaller amounts of Alpha and Beta Cyclodextrin...luckily nothing went wrong due to the later 2 indicating renal toxicity. After that mistake , I took a break and tried to make sure no more errors were made and graduated to injection with a home made .9% sterile saline solution. I used the data from the Cavadex trials which seemed to indicate a 10% decrease in arterial plaque per 400 grams ...roughly.

My results. The periodic enlarged prostate is absolute history, My erections are harder than the have been in 20 years. The Reynauds syndrome is absolute history. My blood pressure fluctuates between 121 and 119. I still take viagra but down in dosage and honestly I was taken both Viagra and Cialis at the same time because honestly they just stopped working.

 

Great results however ...I do have a problem with anemia and or dehydration although my blood test labs are in a normal range...but probably not the most reliable because the last time I had a blood test I wasn't sure how long ago the treatment was, my kidney function is fine and no hearing loss. My biggest series of injections was 235 grams over a period of 3 days.

 

Back to my issues...due to regulation in the US I have not been able to use the same methods as in the Cavadex study it seems that they deliver about 6 grams in at least an IV bag of 500 ML . This may explain that I could be actually have hemolysis (the destruction of red blood cells) due to the high concentration of my delivery which has been 12.5 grams in 60 ML of saline solution or it could be due to dehydration.. I mean, I am kind of turning my blood stream into gravy.

 

I am giving myself a break til these symptoms go away...in the meantime I have ordered a digital Hemoglobin meter to rule out anemia , also I have found a source of sterile IV bags in Canada that will help me with the dilution issue if it is an issue. By the way my delivery concentration was obtained from the expanded treatment routines for the kids with NPC.

 

That was a hell of an introduction , any feed back questions or advice would be greatly appreciated from this group.

[Grooovin1]

This might have been posted earlier, but could someone please point to any human CD research? I know of the cat research  - treating Niemenns Pick disease, but what about human research?

Niemans Pick research is actually on humans.. and check out the Chlorem.com website they have trials from 2 patience that they have published. The problem with the Cavadex trial results is that the reporting of the methods and results is just....shitty.

[Grooovin1]

The real reason for the lack of human trials on HPBCD

 

Not trying to turn this political or classist however the real reason for the lack of a trial is pretty obvious. Here we have a substance that is unpatentable ....that would cost both the healthcare system and the pharma industry billions if it was successfully proven effective (which it will be anyways and I put my life on that) . Just think cardio vascular surgeries would be dropped in the neighborhood of 90% , maintenance drugs like lipitor would be obsolete, heart medications would be gone , ED drugs would be yesterdays news, most vein surgeries wouldn't be needed, fatty liver treatment would be gone , enlarged prostates would be a thing of the past , ocular surgeries wouldn't be need. 

The fact is that cholesterol is huge in deaths in various ways...my discovery is that viruses use cholesterol to infiltrate cells cyclodextrins are proven antivirals, cyclodextrins seem to retard cancer growth due to cancers using cholesterol. With that established let's go further , Hair loss seems to be related to circulation..which is affected by blood flow. There are so many conditions that this substance could solve the medical INDUSTRY will never fund studies and my bet is they may deliver grants to PREVENT studies because they have tons of cash just from a few drugs.

[TheFountain]

What are these products?

 

https://www.google.c...HZEJAKwQ9pwGCAU

 

https://www.google.c...HVI6DisQ9pwGCAU

[Grooovin1]

What are these products?

 

https://www.google.c...HZEJAKwQ9pwGCAU

 

https://www.google.c...HVI6DisQ9pwGCAU

They are a simple reaction to market..people don't take the time to read. Cyclodextrin is a cheap substance ...literally  corn starch. However when taken orally it is treated like a starch and broken down by the digestive system. In other words ...these will extract some of the cholesterol in the food you eat but not enough to have a positive effect on blood cholesterol levels. Google the studies on oral alpha cyclodextrin. 

The biggest problem with delivery is bypassing the the digestive system.

[TheFountain]

They are a simple reaction to market..people don't take the time to read. Cyclodextrin is a cheap substance ...literally  corn starch. However when taken orally it is treated like a starch and broken down by the digestive system. In other words ...these will extract some of the cholesterol in the food you eat but not enough to have a positive effect on blood cholesterol levels. Google the studies on oral alpha cyclodextrin. 

The biggest problem with delivery is bypassing the the digestive system.

 

Links to references please?

[Grooovin1]

Not doing that with information you can google.

[Grooovin1]

I posted a Link on a 6 year study on treating Niemenns Pick disease on humans.

That's all I could find.

 

Read all of it...2 people did have some hearing loss but they were dosing very high and the hearing loss was small.

looks like if you stay under 3-6G per dose its safe.

 

The AU guys used a 6 gram IV dose twice a day and said they had no side effects.

 

I did notice that the NPD Doctors changed the dosing to once a week with a at home IV kit.

They were hitting them once every 2 weeks with a stronger dose before.

 

6 year study on NPD

https://ojrd.biomedc...019-1207-1#Fig1

 

After almost a year of research  it looks like Cyclodextrin helps with

 

Niemenns Pick

COPD 

Aatherosclerosis

Alzheimers.

 

I started taking some CD today a very small dose will let people know how I feel in a few weeks.

Going to build up to 3-4g a day 4-5 times a week.

 

PS: Going to try and get a calcium score done in the next week or so

I want some proof that this stuff works or not.

 

[Grooovin1]

Actually if you look at the study the amounts that cause hearing loss is listed at Grams/Killogram meaning if you weigh 180 pounds you the amount for hearing loss would be 6x90=540 grams in a dose. Be careful when you read those research papers. 

I easily inject 12 grams in one session. Below from an article on hearing loss from cyclodextrin.

 Only when research on the use of HPβCD to treat NPC in preclinical models prompted routine testing in animals at multi-thousand mg/kg parenteral doses, did the ototoxicity of HPβCD come to light.

 

https://www.frontier...2017.00355/full

[Grooovin1]

 

Let us know how the calcium score goes.. So far I have received relief from ED, BPA (enlarged prostate) , Reynauds syndrome and I swear my eyesight is clearer. 

[Grooovin1]

I'm not soured on it. I'm just advising that a little caution is in order. This is one experiment in mice. What happens if you put it in a primate? Or a higher primate (i.e. human)? We don't know.

 

And there is the practical consideration of getting polymerized CD of sufficient purity that you'd feel reasonably safe injecting it into your veins. Having some unpolymerized CD mingled in is a distinct possibility. If you go to China to make this, do you trust them not to screw this up? And you're probably going to have to go to China to get anyone that will deal with you and you can afford.

 

Oral administration is one thing. If it has endotoxins (definitely possible) your digestive tract will generally render them harmless. But IV administration bypasses all that. You really have to be careful what you're injecting directly into the bloodstream.

 

So I've not soured on anything. This is an exciting development. But safely doing this today with a single experiment and the issues with procuring good product should not be underestimated.

Actually they are using it in so many drugs even injectable ones...it has already been marked as safe by the FDA. They are currently using on kids that suffer from Nieman Picks and also a firm called Chorlren has conducted 2 human trials with results published at Cholrem.com

Has anyone found what they believe to be a safe source of HPβCD?  Anyone dosing themselves?

Yes I currently am, check my first post in this thread.

Correct. I do once a day now. I like to go out to eat so I'm going to continue dosing for the foreseeable future.

Yes correct.

Any side effects? I seem to be having a problem with either dehydration or anemia after dosing.

[Grooovin1]

You bring up some very good points.

I agree with you about the safety precautions. I know a lab owner personally, im not sure if his type of lab could make this. He is doing PCR testing for Covid currently.

 

We could always contact the lab they used in the studies. It would really help if one of us was a scientist or expert in this field so we could be sure not to poison ourselves.

 

There seems to be a lot of researchers that believe Beta CD reverses plaque. The polymer version (at least in mice) seems to be more powerful and safer. Heart disease is terminal. (eventually) There has to be cure. 

 

Is there the same safety concerns with Trehalose? I appreciate your insights. Thanks.

I have been sourcing mine from Amazon from an US lab called ChemCenter...the pharma grade HPBCD is staggeringly expensive. After 6 months I haven't had any problems besides possible dehydration or anemia . Just ordered a testing device to keep an eye on my hemoglobin levels even though my last blood test came out normal. 

[Grooovin1]

Wondering why  Cavadex uses beta instead of gamma cyclodextrin when gamma is more absorbable?

They use HPBCD ...the HP is important because Beta Cyclodextrin is dangerous to use this way. 

I am I read the same thing and I would guess it's because the research is changing rapidly.

[Grooovin1]

Hi guys just checking in..

 

Took about 40 Grams of CD over the last 3-4 weeks

At first no side effects at all but last week I started to get some inflammation on some of my plugged arteries (very small ones)

I know this because I took some EDTA months ago and had the same problem.

 

So for now I am off for a few weeks and will restart along with some strong anti-inflammatories.

 

The good news is we now know that the CD is getting to where its needs to be but removing plaque may cause some inflammation.

Next try will include 3 different anti-inflammatories in the hopes of stopping the inflammation before it gets bad.

Take care

Hey... I took 235 grams in 3 days. That was a bit much, but my point is that you  should be able to take 24 grams a day for 10 days with no side effects. 

I really think you should look at the dosing ratios in the Nieman Pick studies . it is listed as MG/KG meaning if the say 2500mg/KG it is multiplied by the patients weight. So for me that would be a twice weekly dose of 2500mgx90KG =225 Grams per 2 times a week. 

My goal is to simple hit around the 350 gram a month which according to one study should give me a 10% reduction in arterial plaque. I am 6-7 months in with about 2200 grams delivered .

[Grooovin1]

If the tubes made you better, why would you continue to use them? People don't continue taking chemotherapy after their cancer is gone.

Sorry I can't link yet as I am new here but they did a study on mice with a "maintenance" dose and the mice lived 10% longer.

If there are no side effects why wouldn't you want to maintain your arterial health as long as possible?