4 replies to this topic

[farware]

I've been trying to interpret studies as to what type of probiotics are counterindicative in autoimmunity

 

E.g. let's say I have autoimmune reactions when TH17 cells get activated I should probably avoid probiotics that are pro-TH17. 

 

Please read:

 

 

Specifically, B. bifidum IF10/10, A8, DSM20239 and LMG13195 strains showed the highest production of IL-17 

http://journals.plos...al.pone.0024776

 

Therefore, it is generally recognized that the anti-inflammatory effect of probiotics in IBD is linked to the down-regulation of pro-inflammatory IL-17 cytokine production https://www.ncbi.nlm...les/PMC4613231/

 

 

Lactobacillus acidophilus Suppresses Colitis-Associated Activation of the IL-23/Th17 Axis

https://www.ncbi.nlm...les/PMC4417982/

 

Now my interpretation is if you have autoimmune disease involving TH17 (autism/candida) you may want to stay away from Bifidum IF10/10 and related or you end up with lots of inflammatory cytokines. However, Lactobillus acidophilus seems to suppress this. 

 

My question, do you interpret this similarly or am I misreading this (difference in vivo/vitro)? 

 

My own experiences with probiotics show similarities (Breve/longum = negative reaction, inflammation but Rhamnosus/Acidophillus seems ok)

 

Any input appreciated!

 

 

 

 

Edited by farware, 23 September 2017 - 09:20 PM.

[farware]

 

Our results showed that DCs exposed to the possible Th17-inducer B. bifidum strains exhibited high IL-1β/IL-12 and low IL-12/IL-10 proportions, a profile compatible with a Th17 cell differentiation. Conversely, the highest IL-12/IL-10 ratio was presented by B. breve BM12/11, suggesting that it could promote the induction of Th1 responses.

 

 

 

Here is an interesting study:

 

B. infantis suppressed IL-17 production 

Therefore, it was assumed that the induction of immunoregulatory IL-10 by B. infantis was, at least in part, important for suppressing the Th17 function in the splenocytes https://www.spandido.../2/181/download

 

Edited by farware, 23 September 2017 - 09:07 PM.

[farware]

Probiotics seem pretty useless at this point. If you take them, you either promote immunity and get an autoimmune reaction because you are now supporting the forces that work against potential pathogens.

 

OR you take an immuno-suppressing probiotic and potentially amplify the attacks against you, inviting more pathogens in leading to proliferation. Sure it can heal for a while from the autoimmune overload but the body does that for a reason.

 

Only solutions seems to me is to try to modulate the immune system and take away possible foods that promote pathogens e.g. focus on removing gluten, dairy, etc for a while until the immune system resets. Then you can reintroduce friendly bacteria. 

 

 

[farware]

As for reference: 

 

The focus of the other doctors, however, was on how to suppress the inflammation with medication, not finding and treating the cause. 

http://drhyman.com/b...immune-disease/

 

If I suppress an autoimmune reaction you may get temporary relief that MAY help the body to get a balance again but you are not treating the causes of the autoimmune reaction

 

 

[farware]

However, further studies indicate that promoting IL-10 and Tregs could have profound inflammatory effects that can help the immune system to rebalance itself

 

The addition of L. casei to the repletion diet normalized the immune response against C. albicans, allowing efficient recruitment and activation of phagocytes, as well as effective release of pro-inflammatory cytokines. In addition, probiotic treatment induced an increase in IL-10 concentrations, which would have helped to prevent damage caused by the inflammatory response. https://www.ncbi.nlm...pubmed/21395664

 

 

CONCLUSION: Our study suggests the potential of cinnamon extract as an anti-inflammatory agent by targeting the generation of regulatory APCs and IL-10+ regulatory T cells. 

https://www.wjgnet.c.../v17/i8/976.htm

 

 

 

According to the studies I have read, Cinnammon can help create Tregs. L-casei seems to help promote IL-10 which may be helpful if you are affected by TH1/Th17 auto-immune responses.

 

I know I react well to Cinammon so that would explain it. Still unsure about L.Casei, I get mixed results from common probiotics found in supermarkets, but a little cautious taking proper ones

Edited by farware, 24 September 2017 - 07:45 PM.