6 replies to this topic

[Bockemossen]

Let’s talk about the potent serotonin antagonist metergoline. This compound is an agonist at D2 and antagonize 5ht2, 5ht6, 5ht7 and most importantly 5ht1a. Antagonizing 5ht1a autoreceptors should upregulate them. This would in turn lead to lower serotonin levels overall. This could fix SSRI induced libido issues and possibly emotional blunting/anhedonia symptoms. Read this thread if you haven’t heard about it: https://raypeatforum...-for-r-d.12908/

People with social anxiety should be extra interested. As social anxiety has recently been associated with elevated levels of serotonin. https://www.scienced...50617115327.htm.

I’m going to mix metergoline with parnate + nortriptyline + memantine to see if it has any benefits on sexual and emotional symptoms.

If anyone have tried metergoline, please tell us about your experience with the substance.

 

[Rocket]

What have you found out?

[kurdishfella]

I tried metergoline , serotonin antagonist like these they just Stop your serotonin from having an effect they dont actually reduce serotonin levels in the brain..Some say its the same thing But I dont belive it. Also if you go on a high enough dosage on these serotonin antagonists it will block all serotonin Receptors. 
Fenclonine is something I always wanted to try it actually deplets your serotonin .

 

 

Edited by farshad, 10 December 2017 - 08:39 PM.

[Bockemossen]

What have you found out?

 

It didn’t seem to go well with the nortriptyline, so I didn’t use it many times. Made my heart feel weird and some other stuff but that could have been from the nortriptyline itself.

But I definitely felt that metergoline had some other effects as well. Some brain fog relief, warmth in my body at some times and other times it made me tiered. I took it again after discontinuing nortriptyline (couldn’t tolerate it), three drops sublingual/oral and it made me feel great and stimulated the day after, both in mind and body. Like others have said on the ray peat forum, I became less inhibited when talking to people after drinking some wine, but I didn’t notice that until the day after. Quite interesting. Though I must take it more consistently to be sure. But I’m a bit wary of using it, especially considering my other meds.

[Bockemossen]

I tried metergoline , serotonin antagonist like these they just Stop your serotonin from having an effect they dont actually reduce serotonin levels in the brain..Some say its the same thing But I dont belive it. Also if you go on a high enough dosage on these serotonin antagonists it will block all serotonin Receptors. 
Fenclonine is something I always wanted to try it actually deplets your serotonin .

​It reduces serotonin synthesis.

[jacobjerondin]

 

It didn’t seem to go well with the nortriptyline, so I didn’t use it many times. Made my heart feel weird and some other stuff but that could have been from the nortriptyline itself.

But I definitely felt that metergoline had some other effects as well. Some brain fog relief, warmth in my body at some times and other times it made me tiered. I took it again after discontinuing nortriptyline (couldn’t tolerate it), three drops sublingual/oral and it made me feel great and stimulated the day after, both in mind and body. Like others have said on the ray peat forum, I became less inhibited when talking to people after drinking some wine, but I didn’t notice that until the day after. Quite interesting. Though I must take it more consistently to be sure. But I’m a bit wary of using it, especially considering my other meds.

 

 

This stuff sounds really promising for me, are you still using it? I'd love to try it, it sounds like a magic bullet for me but I'm pretty concerned about the dopamine agonism. Any dopamine agonist can cause serious receptor downregulation and more importantly, the dreaded dopamine agonist withdrawal syndrome (DAWS), which can be permanent! Doesn't sound like anything to be experimenting with imo, despite the great benefits. But if you used it for a while and then stopped, I'd love to hear if you felt any of that (or not)?

[Bockemossen]

This stuff sounds really promising for me, are you still using it? I'd love to try it, it sounds like a magic bullet for me but I'm pretty concerned about the dopamine agonism. Any dopamine agonist can cause serious receptor downregulation and more importantly, the dreaded dopamine agonist withdrawal syndrome (DAWS), which can be permanent! Doesn't sound like anything to be experimenting with imo, despite the great benefits. But if you used it for a while and then stopped, I'd love to hear if you felt any of that (or not)?

I haven't used it again. No long term effects/side effects. Yes I agree it's risky, little is known about it's D2 agonism. I might try taking it once or twice a week with my psychiatrist.

Read this post by "marybanana"
http://www.pssdforum...1f612&start=130

 

You can read more testimonials on raypeatforum.