I'm currently on vyvanse(called Elvanse here in Germany) at 60mg a day(I'm taking two of the 30mg capsules). I've been on it for at least half a year, before that I was on 54mg of Concerta. Some level of tolerance has already set in, but I still greatly benefit from the effects it gives me on energy, focus, motivation, confidence and sociability. However, its side effects are not worth it to me anymore, so I'm looking for a replacement with similar benefits. Also, the replacement should either have no effect or a positive effect on libido, since I don't want to take a drug that suppresses my libido, it's already low enough. I'm absolutely certain that I will need something that acts on dopamine at least to some degree since
1) Vyvanse gave me EXACTLY the benefits I was looking for, and its main action is increasing dopamine release 2) Even if dopamine was not my main problem, I would need something dopaminergic by now, since my body became used to Vyvanse so when switching to something non-dopaminergic I would definitely have a lack in dopamine
Ideas on what to try:
1) Selegiline - This one sounds very promising, since many users report exactly the same benefits that I got out of Vyvanse: Enhanced energy, focus, motivation, confidence and sociability. Additionally, this one seems to boost libido in many, which would be a welcome benefit for me. The MAO-B inhibition also boosts dopamine, but I would guess the dopamine boost can't compare to Vyvanse, so I would need quite a high dose, maybe like 40mg. Such high daily doses have been studied as antidepressants, so I'm comfortable it will be safe, as long as sticking to a strict MAOI diet, since at such high doses selegiline has some action on MAO-A, too. Only thing I would be somewhat worried about is that selegiline seems to be metabolized into l-methamphetamine and l-amphetamine to some degree, which would be undesirable when trying to get off vyvanse. However, from all I found the metabolization into amphetamines seems to be quite minor, though I wasn't able to find any exact numbers. Maybe someone would be able to chime in here. I'm definitely going to try selegiline at this point, but any info about the metabolization into amphetamines and other things I should be careful about is welcome.
2) Bromantane - Same as with selegiline, users report benefits on energy, focus, motivation, confidence and sociability. Bromantane is also thought to be dopaminergic in its action, though the exact mechanism of action seems to be unknown at this point. Quite unsure about what dosage would be required to replace elvanse.
3) Phenylpiracetam - Seems to show similar benefits to the above two. Unsure about dosage.
4) Amineptine - Seems to act as both a DRI and DRA. Couldn't find much anecdotal experience of this one.
5) Modafinil/Armodafinil - There's not the same reports of effects as with the other three, but they also seem to have some dopaminergic action. From what I found armodafinil would be the better option here, as it has a stronger affinity for DAT and also seems to be a partial agonist at D2 receptors, though I'm unsure if the D2 partial agonism would be good or bad in my case.
Which of the options would you recommend to try in my case, keeping in mind that I have a high tolerance for dopaminergics so I probably need something strong. Also, feel free to suggest any other options.
