Ok so I am being stupid here but I can’t figure this out. I read someone on this forum say the following about C60:
http://www.longecity...ts-home/page-10
“Another interesting article, dealing with atherosclerotic rats, C60 in saline solution and resulting in vasomotor balance shift towards vasorelaxation:
https://particleandf...6/1743-8977-6-5 “
I check the study and find this:
“The aged apoE-/-mice had lower endothelium-dependent vasorelaxation elicited by acetylcholine in aorta segments mounted in myographs and the phenylephrine-dependent vasoconstriction response was increased. One hour after an intraperitoneal injection of 0.05 or 0.5 mg/kg of C60 fullerenes, the young apoE-/- mice had slightly reduced maximal endothelium-dependent vasorelaxation. A similar tendency was observed in the old apoE-/- mice. Hampered endothelium-independent vasorelaxation was also observed as slightly increased EC50 of sodium nitroprusside-induced vasorelaxation response in young apoE-/- mice.”
”The SNP-induced vasorelaxation was shifted toward a reduced responsiveness in young apoE-/- mice treated with 0.5 mg/kg of C60 fullerenes compared with the 0 mg/kg exposed group (figure 4, table 1). This was evident from the EC50 value (16.5 nM (95% CI: 13.4–20.3 nM) which was significantly increased compared to the control group (10.1 nM (95% CI: 8.1–12.6 nM). The EC50 for mice treated with the lower dose was slightly increased (15.7 nM (95% CI: 11.2–22.0 nM), although this was not statistically significant at a 5% level.”
My brain simplifies it like this
When the scientist tried to force vasorelaxation with acetylcholine then:
· vasorelaxation was lower (as in less relaxed) with C60 than without
· vasoconstriction was higher (as in more constricted) with C60 than without
When the scientist tried to force vasorelaxation with sodium nitroprusside (SNP) then:
· vasorelaxation was slightly lower (as in less relaxed) with C60 than without
So how does this mean that “vasomotor balance shifts towards vasorelaxation”? I know sometimes stuff appears to decrease stuff while it actually increases them. For example, when you first hear the word Selective Serotonin Reuptake inhibitor (SSRI), as a normal person you can easily believe that this means that Serotonin will be inhibited as in decreased. But as everyone a little educated knows Serotonin in this case will actually increase, at least temporarily. So I thought that maybe something similar that I’m missing is in place with this vasorelaxation thing. On the other hand, maybe the forum guy is just wrong, mystery solved?
