I am not an expert, but if CD38 consumes NAD+ then more NAD+ will probably also upregulate everything downstream CD38 as a side effect,right? In that case a CD38-Inhibitor would maybe just compenate this effect. Your thoughts?
That's probably correct, but (at least some of) these effects are beneficial. This was also discussed earlier in this thread. CD38 is no fiend, its just a pity that it needs so much NAD.