I take some broad spectrum mushroom extracts as well. The data on mushrooms is quite supportive for health.
Mushrooms do seem more powerful than medicinal plants when it comes to immune health.
Examine has pretty good summary of the benefits of Reishi:
Summary
Ganoderma lucidum, commonly known as the lingzi mushroom, is frequently used in traditional Chinese medicine. Its popularity extends to Japanese and Korean medicine, and it has been making its way west.
Ganoderma lucidum has anti-oxidative effects when supplemented. It also has a therapeutic effect on insulin resistance, reduces the risk of prostate cancer, and can help treat a variety of conditions associated with metabolic syndrome.
The lingzi mushroom is well known for its anti-cancer effects. It is able to activate natural killer cells, increasing their activity and the body’s ability to fight tumors. Supplementing Ganoderma lucidum reduces the chances of metastasis, which is when cancer spreads to another part of the body.
Ganoderma lucidum has a variety of mechanisms, but they are focused on moderating the immune system. The lingzi mushroom is able to reduce immune system activity when the system is overstimulated, and bolster the immune system when it is weakened. In general, Ganoderma lucidum increases the amount of active immune system cells.
Though further research is needed to confirm these effects, Ganoderma lucidum shows promise for a wide variety of cancer-related therapies. It has been shown to be an effective adjunct therapy, which means it improves health when taken alongside other medications, for breast cancer, hepatitis, fatigue syndrome, and prostate cancer. There are not many promising supplements with anti-cancer properties available over-the-counter but Ganoderma lucidum appears to be one of them.
→ source (external link)
Personally I've found Reishi to effectively reduce my adult back acne which has been resistant to even the strongest medication available, Accutane. The anxiolytic effect of Reishi is also powerful, I think it's mediated through several mechanisms: GABA-A receptors, adenosine-agonism and lowering histamine release.