Stem Cells Dev. 2006 Feb;15(1):118-23. Related Articles, Links
Nutraceuticals synergistically promote proliferation of human stem
cells.
Bickford PC, Tan J, Shytle RD, Sanberg CD, El-Badri N, Sanberg PR.
Center of Excellence for Aging and Brain Repair, University of South
Florida College of Medicine, Tampa, FL 33612., James A. Haley Veterans
Administration Hospital, Tampa, FL 33612.
A viable alternative to stem cell transplantation is to design
approaches that stimulate endogenous stem cells to promote healing and
regenerative medicine. Many natural compounds have been shown to
promote healing; however, the effects of these compounds on stem cells
have not been investigated. We report here the effects of several
natural compounds on the proliferation of human bone marrow and human
CD34(+) and CD133(+) cells. A dose-related effect of blueberry, green
tea, catechin, carnosine, and vitamin D(3) was observed on
proliferation with human bone marrow as compared with human
granulocyte-macrophage colony-stimulating factor (hGM-CSF). We further
show that combinations of nutrients produce a synergistic effect to
promote proliferation of human hematopoietic progenitors. This
demonstrates that nutrients can act to promote healing via an
interaction with stem cell populations.
PMID: 16522169 [PubMed - in process]
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