674 replies to this topic

[recon]

Turnbuckle, what do you think about the addition of enzymes such as nattokinase, serrapeptase and lumbrokinase?

I think there’s a study linking nattokinase and serrapeptase to the relief of Alzheimer’s pathophysiology in rats [1].
I am inclined to hope that the enzymes are able to dissolve amyloid plaques if they’re able to cross the blood-brain barrier [2].

Lumbrokinase, on the other hand, should have similar mechanisms.
I wonder if they’re any good for dissolving AGEs at the same time.


[1]:
Serrapeptase and nattokinase intervention for relieving Alzheimer's disease pathophysiology in rat model.
Fadl NN, et al. Hum Exp Toxicol. 2013 Jul;32(7):721-35. doi: 10.1177/0960327112467040.
PMID 23821590
https://www.ncbi.nlm...ubmed/23821590/

[2]:
Amyloid-Degrading Ability of Nattokinase from Bacillus subtilis Natto
Ruei-Lin Hsu, Kung-Ta Lee, Jung-Hao Wang, Lily Y.-L. Lee and Rita P.-Y. Chen. Journal of Agricultural and Food Chemistry. Vol. 57, Issue. 2, Pages 503-508 December 31, 2008
https://pubs.acs.org....1021/jf803072r

[Turnbuckle]

Turnbuckle, what do you think about the addition of enzymes such as nattokinase, serrapeptase and lumbrokinase?

I think there’s a study linking nattokinase and serrapeptase to the relief of Alzheimer’s pathophysiology in rats [1].
I am inclined to hope that the enzymes are able to dissolve amyloid plaques if they’re able to cross the blood-brain barrier [2].

Lumbrokinase, on the other hand, should have similar mechanisms.
I wonder if they’re any good for dissolving AGEs at the same time.


[1]:
Serrapeptase and nattokinase intervention for relieving Alzheimer's disease pathophysiology in rat model.
Fadl NN, et al. Hum Exp Toxicol. 2013 Jul;32(7):721-35. doi: 10.1177/0960327112467040.
PMID 23821590
https://www.ncbi.nlm...ubmed/23821590/

[2]:
Amyloid-Degrading Ability of Nattokinase from Bacillus subtilis Natto
Ruei-Lin Hsu, Kung-Ta Lee, Jung-Hao Wang, Lily Y.-L. Lee and Rita P.-Y. Chen. Journal of Agricultural and Food Chemistry. Vol. 57, Issue. 2, Pages 503-508 December 31, 2008
https://pubs.acs.org....1021/jf803072r

 

 

Serrapeptase and nattokinase look very interesting. I will give them a shot and add them to the protocol. 

Edited by Turnbuckle, 14 March 2018 - 12:11 AM.

[biggyrat]

 

Sorry- I hadn't seen the updated protocol ( post 83).  So you dropped the 2 g of ascorbic acid with the AB Plaque protocol?  

 

Does it matter whether these protocols are taken with or without food? 

 

 

 

The 1/4 teaspoon of C powder is around 1g. Take more if you wish. As for food, I take this with fruit juice. I hold off eating for half an hour or more to insure that it gets going.

 

Thanks Turnbuckle.  Appreciate it. 

[ceridwen]

My tinnitus is always there it used to be sporadic but is a lot worse noe

[ceridwen]

Has anyone here heard of the Bredesen Protocol if so what do think of it?
Has anyone here heard of the Bredesen Protocol if so what do think of it?
Has anyone here heard of the Bredesen Protocol if so what do think of it?

[matrix83]

Has anyone here heard of the Bredesen Protocol if so what do think of it?
Has anyone here heard of the Bredesen Protocol if so what do think of it?
Has anyone here heard of the Bredesen Protocol if so what do think of it?

 

Well, he put out a whole book on it. I certainly think it is a big step in the right direction. 

[biggyrat]

Has anyone here heard of the Bredesen Protocol if so what do think of it?
Has anyone here heard of the Bredesen Protocol if so what do think of it?
Has anyone here heard of the Bredesen Protocol if so what do think of it?

The book is really interesting.  There are places on line that give the protocol also. 

[Mind]

Maybe through TREM2 manipulation: http://www.longecity...imers-patients/

[ceridwen]

Adding a chelator to this stack IP6 and also ENADH. Also R-Lipoic after reading an article that said that 600mg for 80 days stopped the disease. Taking TUDC and Saffron and zinc also using skin patches Vitamin D and K, B complex Vitamins, an anti inflammatory patch HGH and a DHEA tablet. Wondering if I should replace Taurine with Acetyl Carnetine as this is said to protect the brain against beta amyloid toxicity. I am also using lemon balm oil. I would be very interested to know what others on this thread think of this stack

[ceridwen]

There's a smaller book that goes into the Bredesen Protocol. It is called "the last days of Alzheimer's Dementia" by Precious C. Godson,Andy I Yamaha and Judy Skub. This book outlines all the tests you have to do for Biomarkers and the change in lifestyle and all the other details.
But I'm actually doing what Turnbuckle suggested plus the additions that I've mentioned above.

[MidwestGreg]

Turnbuckle, interesting protocol.

 

Do you think it might be useful to add a mechanism to remove aluminum from the body such as drinking silicon rich mineral water?

 

This study, although small in size, demonstrated the removal of aluminum from the body and some of the dementia participants improved on cognitive tests.

 

https://www.ncbi.nlm...pubmed/22976072

 

Abstract

 

There has been a plausible link between human exposure to aluminum and Alzheimer's disease for several decades. We contend that the only direct and ethically acceptable experimental test of the 'aluminum hypothesis', which would provide unequivocal data specific to the link, is to test the null hypothesis that a reduction in the body burden of aluminum to its lowest practical limit would have no influence upon the incidence, progression, or severity of Alzheimer's disease. Herein we are testing the hypothesis that silicon-rich mineral waters can be used as non-invasive methods to reduce the body burden of aluminum in individuals with Alzheimer's disease and a control group consisting of their carers and partners. We have shown that drinking up to 1 L of a silicon-rich mineral water each day for 12 weeks facilitated the removal of aluminum via the urine in both patient and control groups without any concomitant affect upon the urinary excretion of the essential metals, iron and copper. We have provided preliminary evidence that over 12 weeks of silicon-rich mineral water therapy the body burden of aluminum fell in individuals with Alzheimer's disease and, concomitantly, cognitive performance showed clinically relevant improvements in at least 3 out of 15 individuals. This is a first step in a much needed rigorous test of the 'aluminum hypothesis of Alzheimer's disease' and a longer term study involving many more individuals is now warranted.

 

The protocol involves drinking 500ml of silicon rich water twice a day (morning/evening) over a 12 week period. The water has to be drunk within a 10 minute period. Here in the US, Fiji water meets the silicon content requirements.

 

The author, Exely, has several interesting publications. https://www.ncbi.nlm...or_uid=16988476

 

His publications are also posted here: https://www.keele.ac...m/publications/

[Turnbuckle]

Turnbuckle, interesting protocol.

 

Do you think it might be useful to add a mechanism to remove aluminum from the body such as drinking silicon rich mineral water?

 

 

 

 

 

See post #83 where I added a form of cucurmin with high bioavalibility--

 

 

For chelation of metals:

Meriva curcumin (high absorption) — 1-2g

 

Suggested dosing—once a day until symptoms resolve, then every other day. All except the oleuropein, curcumin and nicotinamide (if in pills) can be added to fruit juice.

 

Note: I’ve added curcumin to the protocol as it will likely help with removal of Aβ insofar as it can remove metals that could make Aβ more refractory to dissolution. I’d already been taking Meriva curcumin due to its excellent reduction of knee pain. That it can remove metals from the hippocampus suggests it would be good for memory, and in rats has been found to increase nerve growth factors in the hippocampus that were suppressed by stress.

 

 

 

Cucurmin is known to remove aluminim from the brain in rats--

 

 

Chronic aluminium chloride administration resulted in poor retention of memory in Morris water maze, elevated plus maze task paradigms and caused marked oxidative damage. It also caused a significant increase in the acetylcholinesterase activity and aluminium concentration in aluminium treated rats. Chronic administration of curcumin significantly improved memory retention in both tasks, attenuated oxidative damage, acetylcholinesterase activity and aluminium concentration in aluminium treated rats (P<0.05). Curcumin has neuroprotective effects against aluminium-induced cognitive dysfunction and oxidative damage.

https://www.ncbi.nlm...pubmed/19616038

 

 

[biggyrat]

Hi ... so I've been taking the protocol, every day or every other day , depending on my schedule. 

 

That is ,  for AB plaque, 1/4 teas HEPPS,  2 teas Taurine,   2 caps Olive Leaf ( its a 20% Oleuropein, and label says each cap is standardized to contain 150 mg of Oleuropein).  I know the protocol listed suggested 200 mg of Oleuropein, but since these are 150 each, I opted for more , rather than less thus taking the 2 caps, 300 Oeuropein.  Taking the Hepps/ Taurine with a grape juice / water mix.  

 

For the Tau aspect, I'm taking 4 mg of MB,  1/4 teas or a little less  of ascorbic acid - its not taking away the blue color , not sure why. I know the MB I have says its liposomal, so maybe it has something to do with that? It doesn't list the ingredients that make it liposomal, so I'm not sure about why its says this.  Also, I have Vitamin Research Niaciniamide caps,  500 mg each.  Again, the protocol listed says to take 250 mg of this, but I'm taking the 500 mg.  

 

Doing all of this on an empty stomach, waiting at least 30 min to eat after.  And then with food, I'm taking Healthy Origins Curcumin Phytosome with 1000 mg of Meriva per 2 caps. So I'm taking 2 caps with food.  Along with my other various supplements.  

 

I've been getting  a very unsettled gastro/ intestinal  reaction.  Stomach gurgles a lot, feels very mushy,  and the rest that goes along with that.   This lasts pretty much the entire day and I'm generally doing this protocol mid- morning.  I wondered if anyone else had this reaction and / or if there was any comments/ suggestions.  

 

Thanks much... 

 

 

 

 

[Turnbuckle]

Biggy, I'd first try leaving off the MB and nicotinamide--stomach upset is listed as side effects for both--and if that solves the problem, adding a reduced amount of nicotinamide with food. And finally adding the MB in juice.

[biggyrat]

Thanks Turnbuckle.  

[Fafner55]

My mistake.

 

Edited by Fafner55, 02 April 2018 - 01:57 AM.

[matrix83]

https://www.ncbi.nlm...pubmed/29523960

 

Taurine is an amino acid with the ability to activate autophagy in adipocytes Abstract

Alterations in adipocyte characteristics are highly implicated in the pathology of obesity. In a recent article, we demonstrated that high-fat diet-induced obesity impairs lysosomal function, thereby suppressing autophagy in mice white adipose tissue. Taurine, an amino acid naturally contained in the normal diet and existing ubiquitously in tissues, has been reported to improve insulin resistance and chronic inflammation in animal models, but underlying mechanisms remain unclear. From these findings, we hypothesized that improvement of obese pathology by taurine may be mediated through recovery of autophagy. In matured 3T3-L1 mouse adipocytes, treatment with taurine-promoted autophagy. Moreover, taurine-induced nuclear translocation of transcription factor EB (TFEB), a master regulator of autophagy- and lysosome-related factors. As this translocation is regulated by several kinase pathways, including extracellular signal-related kinase 1 and 2 (ERK1/2) and mechanistic target of rapamycin protein kinase complex 1 (MTORC1), we examined related signaling elements. Consequently, taurine-reduced phosphorylation levels of ERK1/2 but did not alter the phosphorylation of MTORC1 pathway-associated adenosine monophosphate-activated protein kinase or ribosomal protein S6 kinase. Taken together, these results suggest that taurine may enhance TFEB nuclear translocation through ERK1/2 to accelerate autophagy. The effect discovered in this study may represent a novel mechanism for the improvement of obesity-related pathology by taurine.

 

[Ibbz]

Apologies if this has already been posted, but another (double blind placebo) study came out a month ago with positive results for curcumin on Alzheimer's - 

 

http://newsroom.ucla...ucla-study-says

 

"The people who took curcumin experienced significant improvements in their memory and attention abilities, while the subjects who received placebo did not, Small said. In memory tests, the people taking curcumin improved by 28 percent over the 18 months. Those taking curcumin also had mild improvements in mood, and their brain PET scans showed significantly less amyloid and tau signals in the amygdala and hypothalamus than those who took placebos."

 

Note that they were using Theracurmin version of curcumin. (I know from other research Longvida curcumin has also penetrated the Blood brain barrier)

[matrix83]

Does anyone have an Oleuropein recommendation?

 

[Blueflash]

Does anyone have an Oleuropein recommendation?

[Blueflash]

I use one made by lifeline nutrients. Nothing extra added, and 20% oleuropein, which is what I understand to be an effective concentration. Seems to help somewhat with sinuses as well. (I have no affiliation)

[Blueflash]

So I just finished 100 grams hepps along with everything else in the original protocol. Started with 1 gram hepps and 1 gram oleuropein (20 %) in the middle of February. After about 1 week I had a headache/pressure in my head, which cleared after a couple days. This was significant to me, as I very rarely have headaches. Also I'm not a stranger to taurine, OLE, nicotinamide or vitamin c. Started 2 grams/day hepps for about a month, and the last last 10 days it was 3 gram/day. I seem to follow up much better on things without a mental or written note. Also seem to be dreaming much more. I plan to repeat the protocol at some point. Thanks to those who created and contributed to this post.

[Turnbuckle]

I would not stop with the disappearance of symptoms, as there were likely decades of buildup before you noticed a problem. So why not continue and get rid of as much as you can?

[Blueflash]

I'll not wait too long. I need to order more supplements. Curcumin, apigenin and TUDCA look promising.

[Fafner55]

I have taken the Turnbuckle protocol for about 3 weeks with good effect: 500 mg or so HEPPS,  200 mg Oleuropein, 2g Vitamin C. Gradually I've become more clear minded and memory has improved. Like Turnbuckle, I too have noticed more typing errors and forgetfulness increasing over the last few years. Since taking this treatment I feel like my old self - much more mentally agile. There is no doubt that I benefited significantly.

 

The only side effect to this treatment has been a slight headache for the first 5 or 6 days.

 

I tried 2 tsp taurine for one day then dropped it due to diarrhea.

 

I am ApoE ε3/ε3, have none of the major risk factors associated with Alzheimers' except a tendency towards sedentary habits, and am nearly 63 years old. 

 

 

[Turnbuckle]

Melatonin won't cure AD by itself, but it can lessen Aβ generation and tau hyperphosphorylation, and reduce damage to the hippocampus, and so can be used here as an auxiliary supplement --

 

Melatonin in Alzheimer’s Disease

 

Data from clinical trials indicate that melatonin supplementation improves sleep, ameliorates sundowning and slows down the progression of cognitive impairment in AD patients. Melatonin efficiently protects neuronal cells from Aβ-mediated toxicity via antioxidant and anti-amyloid properties. It not only inhibits Aβ generation, but also arrests the formation of amyloid fibrils by a structure-dependent interaction with Aβ. Our studies have demonstrated that melatonin efficiently attenuates Alzheimer-like tau hyperphosphorylation.

https://www.ncbi.nlm...les/PMC3742260/

 

 

 

 

[recon]

What do you think of a preemptive use of Alzheimer drugs?

Probably not acetylcholinerase inhibitors as they are just fixing the end symptoms, but drug like memantine.

[Turnbuckle]

You'll be a lot better off using this protocol than big pharma drugs that are proven not to work, esp. drugs like memantine that only treat the symptoms.

[ceridwen]

Thank you Turnbuckle I'm going to get Dr Green's Rapamycin though. Perhaps I shall combine the 2 or even 3 treat my mitochondria too. I hope it's not too late for me
That is combine your protocols and also take Rapamycin

[aribadabar]

Could there be any issues running the mito fission/fusion protocol with this one concurrently or they better be run consecutively?