674 replies to this topic

[C0rt3x]

I have ordered the 100g of HEPPS, hopefully will be delivered in a few days.

 

 

[C0rt3x]

They have cancelled my order

[Turnbuckle]

Could be a nice little business -- buying it from China, repackaging it and selling it on ebay at a 500% markup.

[kurt9]

I'm wondering if the appropriate solution is to set up an LLC, complete with DBA and like, before attempting to buy anything from a research lab. First, these guys are concerned about liability if someone buys their products and is injured as a result. Second, they are used to selling to commercial accounts such as other research labs. They may want to be sure you are a commercial account before they sell to you.

[C0rt3x]

I'm wondering if the appropriate solution is to set up an LLC, complete with DBA and like, before attempting to buy anything from a research lab. First, these guys are concerned about liability if someone buys their products and is injured as a result. Second, they are used to selling to commercial accounts such as other research labs. They may want to be sure you are a commercial account before they sell to you.

 

I emailed them to explain that I wan an individual and not a business, they accepted that and told me to go ahead and order, so I did but then they cancelled.

I am waiting for their reply.

[Turnbuckle]

You are dealing with clerks at a big corporation. They have rules they can't break, so if you don't check the right boxes, you won't get what you want. 

[bladedmind]

An easier way to get HEPPS is at Amazon, from legit vendor RPI, 100 mg (or one kg).

 

https://www.amazon.com/dp/B01N5LTPCF

 

The RPI website offers 25 mg.  

 

 

[EliotH]

An easier way to get HEPPS is at Amazon, from legit vendor RPI, 100 mg (or one kg).

 

https://www.amazon.com/dp/B01N5LTPCF

 

The RPI website offers 25 mg.  

 

I posted the link on the previous page but apparently no one noticed. I ordered and received it already, even though Amazon said expected delivery would next month. It actually came in a box from netascientific. They offer more options but I don't know if they ship to individuals - haven't had the need to try. They all have the same CAS number so I am pretty sure it is the right stuff.

 

https://www.netascientific.com/ - just enter HEPPS in the search box.

[Phoebus]

Apologies if this has already been posted 

 

 

 

Oleuropein-Rich Olive Leaf Extract Attenuates Neuroinflammation in the Alzheimer’s Disease Mouse Model

•  

Cite this: ACS Chem. Neurosci. 2022, 13, 7, 1002–1013

Publication Date:March 9, 2022

 

https://doi.org/10.1...emneuro.2c00005

 

 

ACS Chemical Neuroscience

Abstract

Alzheimer’s disease (AD) is the most common form of dementia among several neurodegenerative disorders afflicting the elderly. AD is characterized by the deposition of extracellular amyloid-β (Aβ) plaques, disrupted blood–brain barrier (BBB), and neuroinflammation. Several studies have demonstrated the health benefits of olive oil and olive leaf extract (OLE) due to their polyphenolic content. The main phenolic compound in OLE is glycosylated oleuropein (OLG), while the aglycon form of oleuropein (OLA) exists in much lower amounts. This work aimed to evaluate the effect of a low dose of OLG-rich OLE and the mechanism(s) that contributed to the observed beneficial effects against Aβ pathology in the homozygous 5xFAD mouse model. Mice were fed with OLE-enriched diet (695 μg/kg body weight/day) for 3 months, starting at 3 months old. Overall findings demonstrated that OLE reduced neuroinflammation by inhibiting the NF-κB pathway and suppressing the activation of NLRP3 inflammasomes and RAGE/HMGB1 pathways. In addition, OLE reduced total Aβ brain levels due to increased clearance and reduced production of Aβ and enhanced BBB integrity and function, which collectively improved the memory function. Thus, the consumption of OLE as a dietary supplement is expected to stop and/or slow the progression of AD.

https://pubs.acs.org...emneuro.2c00005

Edited by Phoebus, 20 November 2022 - 05:29 AM.

[Phoebus]

 

Published online 2022 Mar 25. doi: 10.3390/antiox11040629

PMCID: PMC9025619

PMID: 35453314

An Olive-Derived Extract 20% Rich in Hydroxytyrosol Prevents β-Amyloid Aggregation and Oxidative Stress, Two Features of Alzheimer Disease, via SKN-1/NRF2 and HSP-16.2 in Caenorhabditis elegans

Go to:

Abstract

Olive milling produces olive oil and different by-products, all of them very rich in different bioactive compounds like the phenolic alcohol hydroxytyrosol. The aim of the present study was to investigate the effects of an olive fruit extract 20% rich in hydroxytyrosol on the molecular mechanisms associated with Alzheimer disease features like Aβ- and tau- induced toxicity, as well as on oxidative stress in Caenorhabditis elegans. Moreover, characterization of the extracts, regarding the profile and content of phenolics, as well as total antioxidant ability, was investigated. The study of lethality, growth, pharyngeal pumping, and longevity in vivo demonstrated the lack of toxicity of the extract. One hundred μg/mL of extract treatment revealed prevention of oxidative stress and a delay in Aβ-induced paralysis related with a lower presence of Aβ aggregates. Indeed, the extract showed the ability to avoid a certain degree of proteotoxicity associated with aggregation of the tau protein. According to RNAi tests, SKN-1/NRF2 transcription factor and the overexpression of HSP-16.2 were mechanistically associated in the observed effects.

https://www.ncbi.nlm...les/PMC9025619/

 

So it looks like together Oleuropein and hydroxytyrosol work on both amyloid and tau plaques. 

[Phoebus]

An easier way to get HEPPS is at Amazon, from legit vendor RPI, 100 mg (or one kg).

 

https://www.amazon.com/dp/B01N5LTPCF

 

The RPI website offers 25 mg.  

 

Did you actually order this? 

 

I ordered it and it now says est deliery date is Jan 11th which seems really out there. Hopefully it actually gets delivered. 

[njurkovi]

An easier way to get HEPPS is at Amazon, from legit vendor RPI, 100 mg (or one kg).

 

https://www.amazon.com/dp/B01N5LTPCF

 

The RPI website offers 25 mg.  

 

Thanks for the link. I am not going to do the protocol right now, but I ordered it anyway because I tend to agree with Turnbuckle that this type of chemical will be harder and harder to get. The delivery date estimate: May 4-8 (??). Even for China this seems excessively long.
 

[Danniel]

It's been a while since anyone posted here. Are there any updates? Anyone can report if they tried the protocol, with which results and how were they measured?

[Meggo]

Is there any known vendor that ships HEPPS to EU countries?

Edited by Meggo, 12 July 2023 - 05:52 AM.

[rarefried]

Trigonelline sounds like a good candidate for this protocol.

 

Trigonelline recovers memory function in Alzheimer’s disease model mice: evidence of brain penetration and target molecule