5 replies to this topic

[BRIGHT]

Quote from new 2017 PMC article by Blagosklonny: "by reducing cellular senescence, rapamycin may be considered to prevent photo aging. Rapalogs (rapamycin and everolimus) can be used not only systemically but also topically. Rapalog-based creams are expected not to interfere with sun tanning and vitamin D3 synthesis."

 

Let's discuss

 

REFERENCE: https://www.ncbi.nlm...les/PMC5752566/

Edited by BRIGHT, 27 January 2018 - 08:38 AM.

[recon]

Interesting. I’m sure the folks over at the Ageless Looks subforum will appreciate the news more.

[BRIGHT]

Moved to Ageless Looks subforum - https://www.longecit...y-blagosklonny/

Edited by BRIGHT, 07 December 2018 - 02:39 PM.

[smithx]

There was also a recent thread about a 100uM solution of azithromycin in vitro killing 97% of senescent fibroblasts, so my idea is to:

 

- First use azithromycin to kill the senescent cells

- Then use rapamycin to preserve the remaining cells

 

I made an azithromycin in 95% ethanol solution today and am applying it only to my left outside eye region (which is actually more wrinkled than the right for some reason) to see if there's a noticeable difference in a week.

 

After that I will make a 5nM solution of rapamycin and apply that. (I just happened to have both of these componds in the freezer).

 

But I wonder if the rapa should be applied intermittently (once a week or so) the same way it's best to dose it.

 

Thoughts?

[BRIGHT]

There are some articles out there if you search pubmed for "topical rapamycin"

 

For example this study (https://www.ncbi.nlm...les/PMC3573457/) found topical sirolimus 1% to be more effective than 0.1%. It was applied nightly for 6 months.

Table 1. Topical rapamycin used for treatment of facial angiofibromas

 

 

 

Edited by BRIGHT, 08 December 2018 - 06:33 AM.

[results]

How did you go with your experiment?