4 replies to this topic

[Ovidus]

I have not seen any discussion on FGF19-understandable given how many such damn peptides have emerged over the last few years alone.

 

However, this does look promising
http://www.longlongl...sociated-aging/

 

Rodent study, of course.... and this may or may not play out as expected in humans. But this part of the above link is interesting:

"For seven consecutive days, they administered FGF19 to different mice models......

All mice models that received FGF19 gained less weight and developed less fat tissue than mice in the control groups, when they had in fact been eating more."

 

To observe an effect in seven days makes me think that the effect size here is rather large.

 

The piece continues with the following comment: "In addition, their skeletal muscles became more developed, as well as their muscle strength."

This is even more significant. To see an effect on muscle mass and strength in seven days is amazing. The vast majority of anabolic steroids do not work that quick. 

Comments???

[Ovidus]

A quote from the paper to hopefully get more people interested in this:

"Several sets of data have shown that the elevation of circulating FGF19 levels by pharmaceutical treatment or by transgenic overexpression leads to increased energy expenditure, reduced fat mass and improvement of lipid and glucose homeostasis in various mouse models, including high-fat-diet-fed mice8,10, leptin-deficient ob/ob mice8,11, mice lacking farnesoid X receptor12 and mice with marked reduction of brown adipose tissue"

[QuestforLife]

What's it's proposed mechanism of action?

[Ovidus]

from the paper:
"FGF15/19 binds to a receptor complex composed of FGFR1/4 and the transmembrane protein β-Klotho (KLB), which leads to activation of the extracellular-signal-regulated protein kinase 1/2 (ERK1/2) and other downstream kinases5,9. The co-receptor KLB enables FGF15/19 to signal through FGFR1/4, and is thus recognized as essential for the biological functions of FGF19 (refs. 2,3)."

 

among other effects....

[Ovidus]

Bump....