Has anyone looked at this combo? Both have long half lifes. Wellbutrin increases norepinephrine but weakly on Dopamine only 20% inhibition on DAT(dopamine transporter). So Modafinil according to wikipedia its mechanism of action is to inhibit DAT and I think thats all it does that is known. At 300mg it inhibits 50% DAT . So the two together wellbutrin and modafinil produce over 70% DAT inhibition and increase dopamine neurotransmission all day with their long half lifes = good constant Anti-Depressant effect.
Edited by farshad, 24 February 2018 - 02:43 PM.
