100 replies to this topic

[zoolander]

These days there are so many novel newly synthesized compounds on the market that it's hard to keep up.

Ones that come to mind are semax (not semanex), FK962 and N-PEP-12.

From the above the only one that is currently commercially avaliable is N-PEP-12. Sold under the brand name "MemoProve".

Here are some abstracts:

Neuropeptide dietary supplement N-PEP-12 enhances cognitive function and activates brain bioelectrical activity in healthy elderly subjects.

Alvarez XA, Corzo L, Laredo M, Sampedro C, Cacabelos R, Windisch M, Moessler H, Crook TH.

Department of Neuropharmacology, EuroEspes Biomedical Research Center, Santa Marta de Babio, Bergonodo, A Coruna, Spain. antonal@eresmas.com

N-PEP-12 is a dietary supplement consisting of neuropeptides and amino acids. In animal experiments, the compound has been shown to enhance cognitive function and reduce neurodegenerative events associated with aging. In this study, we investigated the effects of a single oral dose of N-PEP-12 (180 mg) on brain bioelectrical activity and cognitive performance in healthy elderly subjects. N-PEP-12 induced a significant (p < 0.05) increase in relative alpha-activity power 6 h after administration. This enhancement was accompanied by a generalized decrease in slow Delta-activity. Significant improvement in memory performance subtests was also seen 6 h after N-PEP-12 administration in some but not in all tests. Taken together, these data suggest that N-PEP-12 might be a reliable dietary supplement to be investigated for improving and, perhaps, maintaining brain function among healthy older adults. © 2005 Prous Science. All rights reserved.

Publication Types:

    * Clinical Trial


PMID: 16258593 [PubMed - indexed for MEDLINE]

N-PEP-12 - a novel peptide compound that protects cortical neurons in culture against different age and disease associated lesions.

Windisch M, Hutter-Paier B, Grygar E, Doppler E, Moessler H.

JSW-Research Forschungslabor GmbH, Graz, Austria.

The neuroprotective potency of N-PEP-12, a novel, proprietary compound consisting of biopeptides and amino acids was investigated. Lesion models have been applied in neuronal cultures of embryonic chicken cortex, pre-treated with N-PEP-12 from the first day onwards. On day 8 in vitro neurons were lesioned and cell viability was measured 24 and 48 hours later. To simulate acute brain ischemia, cytotoxic hypoxia was induced by sodium cyanide or by iodoacetate and excitotoxicity by L-glutamate. Ionomycin for up to 48 hours induced calcium overload. The cytoskeleton was disrupted by addition of colchicine. N-PEP-12 shows dose-dependent neuroprotection in all different models. The effect size depends on the recovery time but also on the extent of the lesion. In cases of mild to moderate lesion pronounced dose-dependent effects could be demonstrated. This indicates that chronic exposure to N-PEP-12 is able to prevent neuronal cell death associated to conditions occurring during normal aging and neurological disorders like ischemic stroke, hypoxia, brain trauma, or AD.

PMID: 15750682 [PubMed - in process]

Effects of N-PEP-12 on memory among older adults.

Crook TH, Ferris SH, Alvarez XA, Laredo M, Moessler H.

Psychologix, Inc., Fort Lauderdale, FL 33308, USA. tcrook@psychologix.com

N-PEP-12 is a derivative of cerebrolysin, a brain-derived neuropeptide compound that has been approved for the treatment of Alzheimer's disease (AD) in more than 30 countries. N-PEP-12 is much less potent than cerebrolysin but it can be administered orally whereas the parent compound must be administered through multiple intravenous infusions. This study was undertaken to determine whether N-PEP-12 is effective in improving memory and other cognitive abilities among healthy older adults who have experienced 'normal' age-related memory loss. Subjects were 54 males and females, aged 50 years and older, who presented both subjective and objective evidence of memory loss since early adulthood. The study was a fully randomized, double-blind comparison of N-PEP-12 and placebo. Cognitive assessments were performed at baseline and following 30 days of treatment. The primary outcome measure was the Alzheimer's Disease Assessment Scale-Cognitive (ADAS-cog) Memory score, with the Syndrom Kurz Test (SKT) test, digit cancellation, digit span, verbal fluency and clinical ratings as secondary outcomes. N-PEP-12 treated subjects performed better than placebo-treated subjects on the ADAS-cog Memory score, the SKT, clinical ratings and some, but not other tests. N-PEP-12 may be an effective treatment for memory loss in healthy older adults.

Publication Types:

    * Clinical Trial
    * Randomized Controlled Trial


PMID: 15729085 [PubMed - indexed for MEDLINE]

Of the above papers, I have a copy of the 2nd one mentioned. (PM me for details)

Now where did I put that paper?? Damn! it was right here in front of me!

Edited by zoolander, 30 March 2006 - 01:37 AM.

[acoli]

I'm gonna guinea pig memoprove, I'll let you guys know how it goes.

[arcticjoe]

just by looking at their marketing language it seems to be a load of hyped up crap which might show some results, though probably due to placebo effect rather than a real physiological changes. i call shenanigans

http://esourcenutrition.com/prod174.aspx?s...emoprove_$

[xanadu]

There are lots of novel compounds in the pipeline with interesting possibilities. I will let the early adopters be the test subjects. Perhaps in a few years I will consider trying them.

[zoolander]

Its a shame that these new novel compounds are being synthetical designed by large pharmaceutical companies. Many in Russia. Those crazy Russians.

As a result, most of these compounds are going to be expensive. Considering that cognitive changes occur with age, nootropic supplement sales are going to increase as the age of the population increases. This means that the richer will not just get richer but also smarter. So the next time I am at some swanky party and the rich guy with the BMW trys to make a fool of me, he may just may a total arse out of me. :(

What is up with the name "MemoProve" anyway? How lame is that name. It's like "Anusole" for heamarrhoids. I can't remember the last time a name got on my nerves so much. Pun intented

[benson123]

what other compounds are you refering to Xanudu?

[tracer]

You know, Zoo... I had a choice a while ago - Buy a BMW M3 second-hand or drive my Toyota... I had a great deal on the M3 but I chose to keep my Corolla. Why? So I could afford the other activites which I do. It was a simple choice really... I chose the noots.

A lot of people with Beemers just have different priorities than we do.

[mitkat]

What is up with the name "MemoProve" anyway? How lame is that name. It's like "Anusole" for heamarrhoids.  I can't remember the last time a name got on my nerves so much. Pun intented

I still feel the shame of when my girlfriend saw my box of the somewhat pretentiously named Intelectol® (memory secret™ - the poweful memory enhancer!!!) vinpocetine. [lol]

[zoolander]

Well using BMW was just a generalization. In fact, my experiance is a generalization.

I am a pretty witty and fast thinking guy. I have a very dry sense of humour.

I have been at parties or gathering where you have the guy/girl who thinks that they are better than everyone else. Their reason for acting like they are better than everyone else, from my experiance, is purely materialistic.

Call me sadistic, but this is where I don't mind stepping in. I'm a smart guy, witty quick thinking guy because I have workied hard for it. I am also very happy-go-lucky and enjoy socializing in a diverse range of groups. However, if someone wants to play the "I'm better than everyone else" game then it's time to come back down to earth. I don't get nasty though. I just start asking questions and with a reductionist approach, reality check 'em.

Maybe I need to see a therapist or something but bringing people with superiority complexes down to earth brings a deal of satisfaction to me

[mitkat]

Well using BMW was just a generalization. In fact, my experiance is a generalization.

I am a pretty witty and fast thinking guy. I have a very dry sense of humour.

I have been at parties or gathering where you have the guy/girl who thinks that they are better than everyone else. Their reason for acting like they are better than everyone else, from my experiance, is purely materialistic.

Call me sadistic, but this is where I don't mind stepping in. I'm a smart guy, witty quick thinking guy because I have workied hard for it. I am also very happy-go-lucky and enjoy socializing in a diverse range of groups. However, if someone wants to play the "I'm better than everyone else" game then it's time to come back down to earth. I don't get nasty though. I just start asking questions and with a reductionist approach, reality check 'em.

Maybe I need to see a therapist or something but bringing people with superiority complexes down to earth brings a deal of satisfaction to me

This really made me laugh, because it reminds me of myself (generalization ).

But Zoolander, you don't need a therapist, you are the therapist. [lol]

[zoolander]

Actually, I have read alot of your conversations and have often thought that you remind me of myself.

I like the term "remind me of myself". Its like you have forgotten or something

[doug123]

I guess this is most compelling sudy published:

Int Clin Psychopharmacol. 2005 Mar;20(2):97-100. 
   
Effects of N-PEP-12 on memory among older adults.

Crook TH, Ferris SH, Alvarez XA, Laredo M, Moessler H.

Psychologix, Inc., Fort Lauderdale, FL 33308, USA. tcrook@psychologix.com

N-PEP-12 is a derivative of cerebrolysin, a brain-derived neuropeptide compound that has been approved for the treatment of Alzheimer's disease (AD) in more than 30 countries. N-PEP-12 is much less potent than cerebrolysin but it can be administered orally whereas the parent compound must be administered through multiple intravenous infusions. This study was undertaken to determine whether N-PEP-12 is effective in improving memory and other cognitive abilities among healthy older adults who have experienced 'normal' age-related memory loss. Subjects were 54 males and females, aged 50 years and older, who presented both subjective and objective evidence of memory loss since early adulthood. The study was a fully randomized, double-blind comparison of N-PEP-12 and placebo. Cognitive assessments were performed at baseline and following 30 days of treatment. The primary outcome measure was the Alzheimer's Disease Assessment Scale-Cognitive (ADAS-cog) Memory score, with the Syndrom Kurz Test (SKT) test, digit cancellation, digit span, verbal fluency and clinical ratings as secondary outcomes. N-PEP-12 treated subjects performed better than placebo-treated subjects on the ADAS-cog Memory score, the SKT, clinical ratings and some, but not other tests. N-PEP-12 may be an effective treatment for memory loss in healthy older adults.

Publication Types:

        * Clinical Trial
        * Randomized Controlled Trial

PMID: 15729085 [PubMed - indexed for MEDLINE]

This one just says N-PEP-12 induces an alpha domainant brain wave state. I have read the same about Aniracetam and other conventional nootropics...

Methods Find Exp Clin Pharmacol. 2005 Sep;27(7):483-7.

Neuropeptide dietary supplement N-PEP-12 enhances cognitive function and activates brain bioelectrical activity in healthy elderly subjects.

Alvarez XA, Corzo L, Laredo M, Sampedro C, Cacabelos R, Windisch M, Moessler H, Crook TH.

Department of Neuropharmacology, EuroEspes Biomedical Research Center, Santa Marta de Babio, Bergonodo, A Coruna, Spain. antonal@eresmas.com

N-PEP-12 is a dietary supplement consisting of neuropeptides and amino acids. In animal experiments, the compound has been shown to enhance cognitive function and reduce neurodegenerative events associated with aging. In this study, we investigated the effects of a single oral dose of N-PEP-12 (180 mg) on brain bioelectrical activity and cognitive performance in healthy elderly subjects. N-PEP-12 induced a significant (p < 0.05) increase in relative alpha-activity power 6 h after administration. This enhancement was accompanied by a generalized decrease in slow Delta-activity. Significant improvement in memory performance subtests was also seen 6 h after N-PEP-12 administration in some but not in all tests. Taken together, these data suggest that N-PEP-12 might be a reliable dietary supplement to be investigated for improving and, perhaps, maintaining brain function among healthy older adults. © 2005 Prous Science. All rights reserved.

   
* Clinical Trial

PMID: 16258593 [PubMed - indexed for MEDLINE]

J Neural Transm. 2005 Oct;112(10):1331-43. Epub 2005 Mar 7. 
   
N-PEP-12 - a novel peptide compound that protects cortical neurons in culture against different age and disease associated lesions.

Windisch M, Hutter-Paier B, Grygar E, Doppler E, Moessler H.

JSW-Research Forschungslabor GmbH, Graz, Austria.

The neuroprotective potency of N-PEP-12, a novel, proprietary compound consisting of biopeptides and amino acids was investigated. Lesion models have been applied in neuronal cultures of embryonic chicken cortex, pre-treated with N-PEP-12 from the first day onwards. On day 8 in vitro neurons were lesioned and cell viability was measured 24 and 48 hours later. To simulate acute brain ischemia, cytotoxic hypoxia was induced by sodium cyanide or by iodoacetate and excitotoxicity by L-glutamate. Ionomycin for up to 48 hours induced calcium overload. The cytoskeleton was disrupted by addition of colchicine. N-PEP-12 shows dose-dependent neuroprotection in all different models. The effect size depends on the recovery time but also on the extent of the lesion. In cases of mild to moderate lesion pronounced dose-dependent effects could be demonstrated. This indicates that chronic exposure to N-PEP-12 is able to prevent neuronal cell death associated to conditions occurring during normal aging and neurological disorders like ischemic stroke, hypoxia, brain trauma, or AD.

PMID: 15750682 [PubMed - in process]

Purchase it here. Let me know what you think. Peace out. [thumb]

[exitscratch7]

no one has tried it yet? how was is it best to take this shit? empty stomach? full stomach? after raping goats and destroying the universe by throwing an amygdala at it?

INPUT FEEDBACK PLEASE MY LOVES.

[Bluejay1]

Sorry I am a few years late =)

Ok, I went ahead and bit the bullet. I tried the NPEP-dozen, only a little while into the trial though.

Things I've noticed:

~definitely active (would be a lot to mention for 1 post, so maybe Ill mention later)
~not as strong as Cerebro
~convenient dosing
~fair price, though not cheap. what makes up for the price is THE QUALITY OF THE RECIEVED PRODUCT! So long as Eb-pharm keep the product quality high and at reasonably the same price I will likely continue with my trial and report back results.

Please not I am not expecting the world from it. Only a mild boost. So far it has seemed to do that although not as profound as the injectable product.

Product so far is exceeding expectations.

my2cents

hope leaking this out doesnt drive up the price any or lessen the sourcing-availability

no one has tried it yet? how was is it best to take this shit? empty stomach? full stomach? after raping goats and destroying the universe by throwing an amygdala at it?

INPUT FEEDBACK PLEASE MY LOVES.

[yowza]

There's some more information on this on the 2nd page of the cerebrolysin thread (I'm just posting the link just to connect peices of info. together; not trying to be a one of those typical "This has already been discussed" kinds of people found in too many forums):
http://www.imminst.o...o...28171&st=20



Amidst the supplemental ingrediants seen in memoprove are also 2 peptides that can also be found in Cerebrolysin (note that it's only the peptides and not every ingrediant that is similar between cerebrolysin and memoprove). Also, unlike Cerebrolysin, which is injected, I'm not sure if these 2 peptides would ever cross the Blood Brain Barrier. This is unfortunately why there probably aren't more peptide based supplements on the market?

In my opinion, I see this product as a pretty good daily supplement for your daily nutrient intake at least.

Edited by yowza, 30 October 2009 - 12:39 AM.

[Bluejay1]

No problem Yowza, I do appreciate the link.. Im not into peeing contests either man so I don't get offended is someone corrects me,

Concerning NPEP it DEFINITELY crosses the BBB. First, Im not an overly imaginitive person nor do I dream anything memorable, but NPEP gives me psychotic nightmares even crazier than that of SSRI's or any other psych-med I've tried. Not just an amino acid supplement IMO. I made the mistake of taking 1g at once and boy those nightmares were scary as hell I can still remember them months later.. not like those weak dreams you barely remember as you start to wake only to completely forget.. Hard to explain just what I mean.. But nightmares that wake you and adrenaline is pumping hard like you're being mugged with a cold gun pressed to your forehead and any moment your brains are going splatter on the pavement. I can still remember those things screeching "Feed yourself!" over and over again.. it seems to be a common theme in NPEP nightmares, always these creatures and they want to eat warm convulsing flesh. The first I had was a swarm flesh eating insects, the second these black gorilla-like tree demons with glowing red eyes, the most recent one were blood covered vampire-dwarf creatures (that oddly looked like the dwarf in LOR all soaked in blook with blue-ish rotting cadaver like skin) in platemail armor chucking spears at people.. WTF?!?

Now that I think of it, I haven't gotten any tangible benefits from this stuff other than insomnia and these psychotic nightmares but still a bit too early and bumped myself down to 1/4 a pill / day. That would be funny if some other freaky chemical was doing this.

[yowza]

Hopefully, I didn't come off as correcting anything... Yeah, I understand what you're saying about the whole pissing and moaning that can occur too often on some forums.

As for the dreams, those sound like some pretty tripped out... At least you can remember them. I have a very difficult time recalling any dreams (unless I write something down right when I wake up) that I have but can recognize some if they're recurring. Freud would maybe ask if you have an overdemanding girlfriend.
Seriously though, is there anything else that you're taking besides "Memoprove"?

I notice you use the whole memoprove and N-pep terms interchangeably. I assume you're taking memoprove... Maybe there's something else in it that's causing this? Why do you feel it's N-Pep that's having the noticeable impact?

Edited by yowza, 01 November 2009 - 02:38 AM.

[Bluejay1]

Memoprove = Ebewe pharma's NPEP12, there is no other NPEP12 for sale that I know of since it is still patent pending.

I normally dont remember dreams either, in fact I rarely ever dream unless I take this stuff en masse.

I am only referring to 1 chem.

I think it increase REM at the expense of Delta sleep. Increases sensitivity to caffiene too. Got to love pig brains.

[yowza]

Are you taking anything else along with memoprove?

How do you know if it's the N-Pep that's doing this and not just a combination of other stuff that's in memoprove besides just N-Pep?

[Bluejay1]

This is a pseudo-quip of sorts.

When I got a free sample of MemoP the pill foil looks slightly different than the recent batch I just ordered..

Not to mention the free trial pills had a glossier coat. I'm hoping this means nothing of the new batch I just got - ie the quality of the medication, which of course is my only concern. So once I run out of the free pack I got I;ll learn whether they shipped me the same thing. Hope it aint sugar pillls or Ill send that junk back or report to FDA.. It just seems a little odd that the coatings aren't as uniform as the free stuff I got which was freaking potent .

The effect is definitely due to NPEP my friend. I am rather good at discerning what is doing what.. Being that nothing new has been introduced. It is the only new thing i've done in awhile, I dont even smoke and barely drink..
I'm just a little worried about the batch of pills I ordered, maybe I should pop a gram of that crap and see if I get psychotic dreams in order to tell if it is the real deal like I currently have.

CAn't reallly help you my friend. Just don't expect any miracles from it as I haven't been taking it long enough to notice too many benefits besides the wired-like feeling if I am on too much of the stuff, not to mention the crazy lucid nightmares.

Are you taking anything else along with memoprove?

How do you know if it's the N-Pep that's doing this and not just a combination of other stuff that's in memoprove besides just N-Pep?

[yowza]

Well, if it's from the same company I wouldn't worry too much about it.

Since you haven't been taking anything after starting memoprove, then it's probably how your body's responding to this. How much N-Pep is in each pill?

[Bluejay1]

90mg,

If you wind up giving it a trial Yowza, let me know how yours goes so we can compare notes.

[yowza]

90mg,

If you wind up giving it a trial Yowza, let me know how yours goes so we can compare notes.

I probably won't be able to try anything at least until sometime in December. I'm barely getting by at the moment financially. It's a sad situation. Thankfully, my lease ends in December. It sucks not getting any money to spend. All I've been able to do is talk about this stuff even though I'd like to trial the Cerebrolysin and a number of other nootropics.

[Bluejay1]

You should def try NEP12 first before Cerebrolysin, its cheaper, no pins needed and you can dose it easier. It is basically the same think just watered down a bit.

90mg,

If you wind up giving it a trial Yowza, let me know how yours goes so we can compare notes.

I probably won't be able to try anything at least until sometime in December. I'm barely getting by at the moment financially. It's a sad situation. Thankfully, my lease ends in December. It sucks not getting any money to spend. All I've been able to do is talk about this stuff even though I'd like to trial the Cerebrolysin and a number of other nootropics.

[yowza]

Well, I'm kind of pretty dry right now but will consider ordering some when I can.

There's a site Ebewe Pharma (not their official site) uses for marketing purposes found at
http://www.everpharm...n/products.html. They list memoprove (along with another supplement known as cebrium) as "food supplements".

The products website (www.memoprove.com as listed at the link I posted above) doesn't impress me much. They don't list the ingrediants and it seems to be all hype. A

Are there any details on the back of your memoprove packet that you can scan that may list the ingrediants? If you don't have a scanner, would you mind maybe typing these out?

[yowza]

I looked online trying to find an answer to my question that I just posted and wasn't able to come up with much. If there's any helpful info. on the back of your memoprove packet feel free to post it.

Up until now, I was under the impression that memoprove was a combination of different vitamins and other nutrients. However, I'm beginning to think that N-Pep-12 is the only nutrient in this memoprove product?

I also am beginning to realize that N-Pep being a single fragment from Cerebrolysin doesn't necessarily mean it's a single peptide (rather a single fragment containing a blend of 12 different peptides). I wonder what peptide combination goes into making N-Pep-12?



Here's how I think memoprove was developed:
I'm guessing a less potent oral variation of Cerebrolysin was developed by Ebewe but ultimately tossed to the wayside as just a research experiment (probably due to the lower potency, lower bioavailability, and not have lasting effects up to 3 months after taking it for a couple of weeks like the injectable cerebrolysin I'm guessing). To recoup some of the costs Ebewe pharma probably developed their "Food supplements". Since not all the ingrediants of cerebrolysin are probably orally bioavailable, by handpicking only the N-Pep-12 aspect out of cerebrolysin, they may have been able to market Memoprove?

On the Cerebrolysin thread (pg. 5 post 4) I mentioned a review I found on Cerebrolysin.

Here's a review that a doctor (who frequented some forum out there) wrote on Cerebrolysin:
http://wiseyoung.wordpress.com/2009/02/10/271/
QUOTE Cerebrolysin is a peptide mixture isolated from pig brain. A neurotrophic peptidergic mixture produced by standardized enzymatic breakdown of lipid-free porcine brain proteins, cerebrolysin is composed of 25% low molecular weight peptides (<10K DA) and 75% free amino acids, based on free nitrogen content [1]. The mixture has relatively high concentrations of magnesium, potassium, phosphorus, and selenium [2], as well as other elements [3, 4]. While the drug has antioxidant properties, it is much less than trolox or vitamin E [5]. The active ingredient(s) in the mixture are not known. Two concentrates of the peptide fraction of cerebrolysin are being tested, one called EO21 and the other N-PEP-12 [6].

Earlier in this thread (on the previous page) I probably incorrectly said that memoprove contains 2 peptides that can also be found in cerebrolysin (I was thinking of the EO21 and N-Pep-12). However, it appears that EO21 isn't in Memoprove as I had originally thought...? It appears to only be the N-Pep-12 fraction that's included in memoprove?

Edited by yowza, 03 November 2009 - 10:41 PM.

[Bluejay1]

hey, you're asking a bunch of good questions, most of which I dont have the answer to. Concerning the memoprove Im 99% certain all it has in it is 90mg NPEP12, and nothing else besides pill fillers, glazes and that sort of thing. Honestly I wouldn't want the full on effects of something stronger than memoprove to last for 3mo! That would probably be too much for me. The pills are quite strong even though they are are much weaker than Cerebrolysin.

I have no idea what their other oral product, Cebrium is. It doesn't even say on their website besides the listing of some common AA's. I seriously doubt those AA's would be effective unless they are bound to form peptides that cross BBB. Thanks for bringing that one to my attention.

I'm also not sure what you mean by, EO21 - namely I am not familiar with that compound. More info or a link on that?

The best way I can summarize the Memoprove is that 1 pill (90mg) may be too much for me as it became so activating it started to aggrevate my insomnia, so lately I've cut the pill into 4ths, later on I will move back to halves, then if my body acclimates to it without insomnia I will jump back up to 90mg /day. The stuff is challenging such that it is obviously not just a plain jane amino acid supplement. I can't really give more info than that as I haven't had more than 2mo experience with it. When I got the stuff I first made the mistake of underestimating and took WAY too much with interesting results. I'm trying to get some positive results from it now so I expect it will take a little effort on my part to get the dose right and allow my body time to adjust.

[Bluejay1]

Just pubmed N-PEP-12, when I did 3 articles show up. It's a legit compound, I just have no idea what it does yet lol

[yowza]

Concerning the memoprove Im 99% certain all it has in it is 90mg NPEP12, and nothing else besides pill fillers, glazes and that sort of thing

That's what I thought.

This makes sense since here's how things seem to add together without getting too specific:
Amino Acids (contained in each peptide)--->peptides (each one built up out of a specific combo of amino acids)--->Specific Peptide Fragment used in Memoprove (N-Pep 12; a combination of 12 peptides)

While I already knew a specific amino acid sequence adds into making a peptide (and peptides go into making a fragment), I just got screwed around with various sites introducing memoprove as "a blend of amino acids and peptides" thinking there was more than just the N-Pep-12 in memoprove.

I have no idea what their other oral product, Cebrium is. It doesn't even say on their website besides the listing of some common AA's. I seriously doubt those AA's would be effective unless they are bound to form peptides that cross BBB. Thanks for bringing that one to my attention.

I have no idea how Ebewe developed Cebrium but I have a good idea as to why. It seems like nothing more than a daily amino acid supplement you'd find at the local Walgreens. The only thing that seems to seperate it are that the amino acids are in "patented peptone form" whatever that means?

I'm also not sure what you mean by, EO21 - namely I am not familiar with that compound. More info or a link on that?

All I know about EO21 was the information given in that Cerebrolysin review. It's kind of tough to explain the concept behind a "peptide fragment" as to what it is exactly. Like N-Pep, this is another kind of fragment that's been derived from Cerebrolysin.

I haven't found any products trying to market EO21 but will link to these if I do.

The best way I can summarize the Memoprove is that 1 pill (90mg) may be too much for me as it became so activating it started to aggrevate my insomnia, so lately I've cut the pill into 4ths, later on I will move back to halves, then if my body acclimates to it without insomnia I will jump back up to 90mg /day. The stuff is challenging such that it is obviously not just a plain jane amino acid supplement. I can't really give more info than that as I haven't had more than 2mo experience with it. When I got the stuff I first made the mistake of underestimating and took WAY too much with interesting results. I'm trying to get some positive results from it now so I expect it will take a little effort on my part to get the dose right and allow my body time to adjust.

While N-Pep is made up of peptides, each of which are made of amino acids, it's definitely not some plain 'ole amino acid supplement. Although, I was kind of under the impression that it didn't have much benefit besides supplying the body with amino acids (seeing as how peptides usually get broken down in the digestive tract).

Do you notice a pronounced effect during the daytime or is mainly just at night?

Just pubmed N-PEP-12, when I did 3 articles show up. It's a legit compound, I just have no idea what it does yet lol

I don't either. It would be interesting to find out though.

Did these 3 articles that you found mention how the N-Pep was administered? (was it by mouth?)

[trevyn]

- Novartis recently bought Ebewe Pharma's generics business (announced May 2009, approved Sep 2009). This specifically did not include Ebewe's "injectable neurological products business" -- i.e. Cerebrolysin.

- The "new" Ebewe that now makes Cerebrolysin/N-PEP-12 is "Ebewe Neuro Pharma". ebewe-neuro.com was active for a while, it now redirects to everpharma.com but displays the same Ebewe Neuro site. (Impending name change?)

- N-PEP-12 is an unspecified "derivative of cerebrolysin" "consisting of biopeptides and amino acids". I doubt you'll find anything more specific than that, but I'd love to be proven wrong. I personally would not be surprised if it just is Cerebrolysin prepared for tabletization.

- E021 is a "peptide fraction" of Cerebrolysin, from my reading all the peptides in Cerebrolysin without the amino acids. It shows up in some studies, but is not available for purchase, and is slightly less effective than Cerebrolysin anyway. (e.g. PMID 9700667)

- Peptides are somewhat orally bioavailable, but quite poorly. (PMID 10837560)

- My favorite quote so far: "Cerebrolysin is probably not an appropriate treatment for disorders that are less profound than AD because it can only be administered through multiple (often 20) intravenous infusions." (PMID 16258593)