So we're back to looking for mTORC1 inhibitors and telomere elongators. What about methylation, DNA damage and epigenetic changes though?
Nate-2004, You're right.
I too come to the same conclusions.
After a while, I will publish a modernized method that includes complex therapy.
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The essence is as follows:
1. Extension of telomeres is a necessary (really necessary!) Action.
However, elongation of telomeres causes acceleration of the epigenetic clock.
This may mean an increased likelihood of some types of cancer, for example, melanoma. Therefore, together with 1 point, item 2 is mandatory.
2. Change in the profile of gene expression for a younger age.
The change in the gene expression profile to a younger age is, in my opinion, achieved by the following groups of substances:
a) substances that shift the hormonal balance toward a younger age.
b) substances that cause activation of sirtuins in cells.
c) substances and controls that change the profile of gene expression when they are in the bloodstream (temporary inclusion).
By indirect (not straightforward!) Signs, one can judge the recoil of the epigenetic clock to a younger profile.
From points 1 and 2 it follows that the body will maintain itself in a fairly young state, until we come across the following things:
a) the increasing thickness of the intima-media complex of the common carotid artery (both left and right)
b) decrease in the content in the brain of vitamin B12
c) Glucosepane
The solution of these problems will be discussed in paragraphs 3 and 4
3. Increase own pool of stem cells
4. Measures to prevent individual changes in the body associated with aging.
It will be interesting!
