18 replies to this topic

[nooguyz]

I was planning to take a couple of MAOIs because I have a very overactive MAO system, or at the very least least MAOA. But now I realized - MAOIs are both addictive and they build tolerance. So I wonder - is it still possible to cycle them? And if not, then what should I do about it? Cycle MAOIs every 2-3 weeks by adding more supplements to produce more dopamine, GABA and other neurotransmitters that I underproduce (I am already planning to take supplements that enhance their production alongside MAOIs)?

 

What is the best solution here?

[Nate-2004]

Interesting, I was not at all aware of this issue. So you can build a tolerance to say, rhodiola? Maybe stick with lithium orotate, b6 and EGCG, and cycle rhodiola. The first three will just optimize the situation with tyrosine hydroxylase upregulation, substrates, some minor MAOB inhibition and COMT inhibition. The rhodiola can come in and do the rest. Or cycle EGCG with rhodiola?

Edited by Nate-2004, 06 March 2018 - 09:45 PM.

[CWF1986]

How do you know you have an "overactive MAO system"?

 

Psychiatrist and researchers don't know enough to say that MAOi's work because they reduce the effects of an 'overactive MAO system'.  They only know that through the mechanism of irreversible MAO inhibition amongst other properties that certain MAOi's exert, a certain percentage of people with depression and some other disorders achieve relief of depression symptoms.  

 

We're not at a point where we can pinpoint the physical cause of depression and prescribe a specific medication to fix it.  It's a very complicated disorder and there may not even be one type of depression just as there isn't one type of cancer that's treated the same way.  In a sense, we're still in the dark ages regarding mental health.  

 

All we can do is say that different antidepressants with different pharmacologic profiles treat some symptoms of depression in a certain percentage of people.

 

For example, if someone is very lethargic and can't get moving, not prone to anxiety, and sad most of the time than buproprion might be a good fit because it has 'activating' properties to it so it might be able to treat the symptom of lethargy and mood symptoms.  We don't know enough to say that buproprion is 'balancing' this person's neurotransmitters like the 30 second commercials say.  

[Nate-2004]

Not sure he's talking about depression though. Some people have more COMT, some people just want more dopamine, frankly I can see why. It not only feels good, makes you quick witted, potent and horny but also it makes you motivated and productive. It's something worth trying to hack if you can. I'd just cycle them if you can but take a break for a while, use the combination I suggested above. It should keep you at least optimized until you go back on it.

[nooguyz]

Interesting, I was not at all aware of this issue. So you can build a tolerance to say, rhodiola? Maybe stick with lithium orotate, b6 and EGCG, and cycle rhodiola. The first three will just optimize the situation with tyrosine hydroxylase upregulation, substrates, some minor MAOB inhibition and COMT inhibition. The rhodiola can come in and do the rest. Or cycle EGCG with rhodiola?

Yeah, I've read numerous reports that recommend cycling Rhodiola weekly, taking a week's break. Some say it's every 2-4 weeks, but knowing how substances affect me (even alcohol and weed), I'd say I'd be on the other side of the scale. I think I'll skip Rhodiola because of two reasons, the second one being that it's a DHT inhibitor, and that's my main issue. I think even my depression comes mainly from lack of Dopamine - on days when I do things (and if I take stimulants), I actually feel great. The longer this lasts and the more things I get done, the better I feel overall.

 

To comment on your suggestions (and I do appreciate them, so please don't see my comments as me criticizing or something - people get that idea from me sometimes, and I don't really know why):

Lithium I will try - I have to wait long shipping times in Europe. I am also waiting for a few other vitamins/minerals to arrive.

I'm already taking B6 daily in higher-than-RDI doses. I will reduce the dosage once I receive a precision scale, now I'm just messing around with powder on the edge of my folding knife, haha. I started that recently, but since it's water-soluble, the effects should be noticeable within the hour and not build up over a period of time, and honestly - I don't feel any better at all.

EGCG - I haven't read about it yet, and it's on my todo list. It's likely I will be taking it. Strong Macha tea either makes me calm and sleepy (I really hate being sleepy until my body is worn out and I have to sleep to get more energy - if I could I'd love to stay awake for days, working, but unfortunately that is not possible in a human body).

Rhodiola, I actually commented above, hah.

 

How do you know you have an "overactive MAO system"?

 

Psychiatrist and researchers don't know enough to say that MAOi's work because they reduce the effects of an 'overactive MAO system'.  They only know that through the mechanism of irreversible MAO inhibition amongst other properties that certain MAOi's exert, a certain percentage of people with depression and some other disorders achieve relief of depression symptoms.  

 

We're not at a point where we can pinpoint the physical cause of depression and prescribe a specific medication to fix it.  It's a very complicated disorder and there may not even be one type of depression just as there isn't one type of cancer that's treated the same way.  In a sense, we're still in the dark ages regarding mental health.  

 

All we can do is say that different antidepressants with different pharmacologic profiles treat some symptoms of depression in a certain percentage of people.

 

For example, if someone is very lethargic and can't get moving, not prone to anxiety, and sad most of the time than buproprion might be a good fit because it has 'activating' properties to it so it might be able to treat the symptom of lethargy and mood symptoms.  We don't know enough to say that buproprion is 'balancing' this person's neurotransmitters like the 30 second commercials say.  

Well, I certainly wouldn't trust psychiatrists, most of who say that everything is psychological and if not, "you just have to manage it by doing this" - that has never worked for me. So instead, I took a look at my genes. All genes that are associated with MAO activity are overactive in my system, and most genes that produce neurotransmitters are inhibited. That's from what I could find spending a night or two researching on caffeine. I know a lot of that information is heavily underresearched, but it all correlates with my experiences throughout my life and how I reacted to various substances, life situations and all of that, so I am rather confident about my findings in genetics.

 

Speaking of depression though, my main problem is lack of dopamine. I can feel sad, anxious, whatever, but as long as I can concentrate and do not have racing thoughts, I will sit down and do my thing, and feel great about myself afterwards. Of course it would be great to not feel those other negatives while doing those things - it would be a more pleasant experience overall, I would suppose.

 

In short - my main problem is that it's very hard for me to feel like doing anything, and depending on the substances I ingest - I might feel like doing something, but my thoughts are racing and I cannot concentrate. Sometimes I can concentrate but not feel like doing anything "productive" but I can get myself to watch a TV show I enjoy or play a video game that I like or prepare food or something else. Whenever I get a dopamine kick from some substance, it helps me substancially. Sometimes I can't concentrate still, but I am still able to do something, and that's the important part for me.

 

Not sure he's talking about depression though. Some people have more COMT, some people just want more dopamine, frankly I can see why. It not only feels good, makes you quick witted, potent and horny but also it makes you motivated and productive. It's something worth trying to hack if you can. I'd just cycle them if you can but take a break for a while, use the combination I suggested above. It should keep you at least optimized until you go back on it.

You're right 100%. :-) Dopamine kick makes me feel like "myself". Normally I just feel like I am not me, but I cannot get myself to be "myself" no matter how hard I try. Trying in my normal state just makes me make a lot of mistakes, both socially and practically, which then leads me to feel like a failure when I look back the next day or the day after that, or whenever the consequences of those mistakes kicks in. Not to mention my total lack of motivation and constant unproductivity that I mentioned.

 

 

//On topic of multiple MAOIs: 

I still want to learn about stacking and cycling MAOIs, and if taking different MAOIs, cycling them, would be an option, or if they all would just lose efficacy over time, and I would have to go back to the normal "not myself" for a week or two, not being able to work or do anything again. Really, I should ask the same question about dopaminergic supplements - if I can cycle them and still get higher levels of dopamine (and for that matter other neurotransmintters), or if they just all lose efficacy and I have to stop for awhile, to feel some mental pain for awhile, haha.

[Nate-2004]

This is why Wellbutrin works well for some since it is a very mild DRI and much stronger NRI. Many MAOIs are rough because of their awful long list of food and drug interactions. MAO-B is safer to inhibit but apparently as I learned from this thread there's a tolerance.

 

You might also try following my guide to conquering depression. No one thing to try helps and that's the point of the guide, most people try something, it works a little then they discard it, not realizing it's a smaller, required piece of the machine.

[nooguyz]

This is why Wellbutrin works well for some since it is a very mild DRI and much stronger NRI. Many MAOIs are rough because of their awful long list of food and drug interactions. MAO-B is safer to inhibit but apparently as I learned from this thread there's a tolerance.

 

You might also try following my guide to conquering depression. No one thing to try helps and that's the point of the guide, most people try something, it works a little then they discard it, not realizing it's a smaller, required piece of the machine.

Well, honestly I don't mind food-drug interactions - I do not eat many foods, my diet would drive most people crazy, but it's healthy even in a precautionary way. I know that you cannot eat anything with tyramine, which includes teas, and I love teas because I cannot find a non-water alternative to drink other than tea... I exclude all sweeteners, sugars, coffee, carbonated drinks, dairy... Coconut water is the only alternative I have found, and it is unfortunately very costly. It'd cost me 3eu for a glass of coconut water, and that's about twice of what I spend on ALL that I eat per day on average, so I cannot afford that. If someone has suggestions for nice drinks - feel free though, it would really help me out to cut off teas (and caffeine, of course).

 

I will check out your guide - I was having trouble yesterday and so far today (to an extend) to get myself moving and doing something, but perhaps now I will get my ass moving a little. I still want to reply to another thread here, but I need to do some research before I do. I'll comment on your depression guide after I read it.

 

By the way, if someone still has any input about MAOI supplement tolerance and cycling, please - do add to the topic!

[CWF1986]

I hope I didn't ruffle your feathers with my post.  I should of glossed over your post history before I responded.  A lot of people on these boards... or in general just see the little commercials or read short articles on depression and think they understand how it works when as you already know it gets much much more complicated real quick.  

 

I had some thoughts and experiences about dopaminergics and cycling a few years ago because of adhd, but was prescribed adderall and nortriptyline for adhd and fortunately I have a great response to the combination in treating adhd in addition to treatment of anxiety and depression.  I'm one of those lucky people who hasn't developed tolerance to the positive effects of adderall.  I attribute that to getting lots and lots of exercise.  Granted that's speculatory.

 

I've tried theacrine with great results.  In combination with adrafinil, I get the closest to the results I've had with the above medications for adhd.  I would have some coffee with it too when I needed to actually get up and move around for certain tasks as opposed to sit down and focus.  I still do this when I take a few days off the adderall.  I took theacrine for a month twice a day at 200mg morning and 100mg afternoon, but during that month I never experienced any tolerance.  I rapidly develop tolerance to caffeine within about two weeks.  

 

The combination of phenylpiracetam and adrafinil works great for about a week, then I can't tell I'm taking the phenyl anymore.  

 

I get very little out of adrafinil taken by itself.  

 

Rhodiola works okay.  Mostly, I find it most useful for getting focus and motivation back after very stressful periods of time.  It does little for me during normal circumstances.  

 

Subulthiamine in combination with caffeine is outstanding for a couple of weeks, then tolerance rapidly builds.  What's great about this one is that it actually increases dopamine receptor density as opposed to reducing it like most.  I can't remember which d type is effected the most off-hand.  I have not tried it in combination with theacrine.... hmmm

 

Uridine taken at night helps with energy and motivation the next day for me.  My understanding is that it increases dopamine receptor density.  I remember it would turn off the stimulatory effects of adderall and I used to take it night.  

 

I have taken wellbutrin before.  It's great more energy level and moods, but only okay as far as focus and concentration goes.  It hikes anxiety levels more than adderall for me, but of course ymmv.  I would actually say it does a better job for motivation than adderall for me.  But it doesn't help nearly as much for the focus and does nothing for adhd restlessness.  

 

I used to know so much more about the moa's and pathways for these substances and the level of research but it's been too long since I've looked that stuff up.  So if nothing else, I hope I've given you some food for thought.  

 

If we're talking pharmaceutical irreversible MAOI's, then my understanding is that you're not going to get much more activating than Parnate and selegeline.  Parnate in and of itself in addition to both MAO A and B inhibition is a dopamine releasing substance but is weak compared to amphetamine and selegeline has levo methamphetamine as a metabolite.  Most reports I've read of Nardil is that it tends to be much more calming and can even be sedating.  It has metabolites that have effects on GABA.  

 

If we're talking about the MAOI activity of various herbals... then keep in mind that a lot the research that points this out doesn't go as far as finding out if the level of the MAOI is clinicallly relevant.  

[nooguyz]

I hope I didn't ruffle your feathers with my post.  I should of glossed over your post history before I responded.  A lot of people on these boards... or in general just see the little commercials or read short articles on depression and think they understand how it works when as you already know it gets much much more complicated real quick.  

 

I had some thoughts and experiences about dopaminergics and cycling a few years ago because of adhd, but was prescribed adderall and nortriptyline for adhd and fortunately I have a great response to the combination in treating adhd in addition to treatment of anxiety and depression.  I'm one of those lucky people who hasn't developed tolerance to the positive effects of adderall.  I attribute that to getting lots and lots of exercise.  Granted that's speculatory.

 

I've tried theacrine with great results.  In combination with adrafinil, I get the closest to the results I've had with the above medications for adhd.  I would have some coffee with it too when I needed to actually get up and move around for certain tasks as opposed to sit down and focus.  I still do this when I take a few days off the adderall.  I took theacrine for a month twice a day at 200mg morning and 100mg afternoon, but during that month I never experienced any tolerance.  I rapidly develop tolerance to caffeine within about two weeks.  

 

The combination of phenylpiracetam and adrafinil works great for about a week, then I can't tell I'm taking the phenyl anymore.  

 

I get very little out of adrafinil taken by itself.  

 

Rhodiola works okay.  Mostly, I find it most useful for getting focus and motivation back after very stressful periods of time.  It does little for me during normal circumstances.  

 

Subulthiamine in combination with caffeine is outstanding for a couple of weeks, then tolerance rapidly builds.  What's great about this one is that it actually increases dopamine receptor density as opposed to reducing it like most.  I can't remember which d type is effected the most off-hand.  I have not tried it in combination with theacrine.... hmmm

 

Uridine taken at night helps with energy and motivation the next day for me.  My understanding is that it increases dopamine receptor density.  I remember it would turn off the stimulatory effects of adderall and I used to take it night.  

 

I have taken wellbutrin before.  It's great more energy level and moods, but only okay as far as focus and concentration goes.  It hikes anxiety levels more than adderall for me, but of course ymmv.  I would actually say it does a better job for motivation than adderall for me.  But it doesn't help nearly as much for the focus and does nothing for adhd restlessness.  

 

I used to know so much more about the moa's and pathways for these substances and the level of research but it's been too long since I've looked that stuff up.  So if nothing else, I hope I've given you some food for thought.  

 

If we're talking pharmaceutical irreversible MAOI's, then my understanding is that you're not going to get much more activating than Parnate and selegeline.  Parnate in and of itself in addition to both MAO A and B inhibition is a dopamine releasing substance but is weak compared to amphetamine and selegeline has levo methamphetamine as a metabolite.  Most reports I've read of Nardil is that it tends to be much more calming and can even be sedating.  It has metabolites that have effects on GABA.  

 

If we're talking about the MAOI activity of various herbals... then keep in mind that a lot the research that points this out doesn't go as far as finding out if the level of the MAOI is clinicallly relevant.  

Well, I don't look through post history myself when replying either. You're definitely right about people like that... I have a friend who just watches YouTube videos all day of what I see as salesman type of youtubers, and for him they are full of credible information and he feels like he knows everything. Not even believes, but "knows the truth". But maybe that's an extreme, haha. Anyway, onto the post!

 

Well, I have tried getting a prescription for dexamphetamines myself, but in Europe it's a completely different story than the US, so unfortunately that didn't work out. Glad you found a solution to your ADHD though, I know how it feels!

 

Wow, I actually looked up theacrine, but for some reason I didn't have it in my todo list. Reading your experience and doing light research, it seems like it's exactly what I need, although 300mg/day would cost around 30eu/month off eBay, and that's always the cheapest source for anything that I can find, so unless it works wonders by itself, I definitely cannot afford it. I spend less than twice that on food for the whole month.

 

But I'm still interested - what is the dose of Adderal that you would compare to 200mg and 100mg of theacrine, and is it Adderall or XR? Perhaps you can draw more comparisons of some sort?

 

Racetams and finils don't interest me precisely for that reason. 150mg Modvigil pill didn't do much for me. Still couldn't focus and didn't feel motivated - it was a very disappointing experience.

 

Rhodiola is also a DHT inhibitor, so I crossed it off. I also don't have stressful periods - I'm at risk of becoming homeless again if I don't fix my brain before I run out of money again, and I can't say I feel stressed or even mcuh anxiety. I don't stress about events so much, and I only feel some anxiety, but that comes from me not being myself, which is cured by dopamine kick from something like Adderall.

 

I'm interested about your dosage for Sulbutiamine - the recommended dosage that I found was around 750mg, and that would end up costing me around 25-30eu/month if we aren't counting the cycling, and since I'd have to cycle, I'd have to buy other supplements as well, which also takes it out of the picture, unfortunately...

 

Hmm, that's an interesting point with Uridine. It was on my todo list, so I did a preliminary research while answering. It seems like I might benefit more from ALCAR than Uridine, especially since I already eat plenty of broccoli daily (source of Uridine). It's also very costly to supplement - 15eu/month. And I'm not sure about my receptor density, but I am sure about severely underproducing dopamine and breaking it down way too quickly when I do get a kick, so I think it's best to cross it off for me or switch it up to ALCAR instead.

 

Thank you for your long and detailed reply! That's the kind of information that I'm looking for. :-)

 

Good point about research and MAOI activity - I will look more into experience reports like yours for the herbs that I went through already and for those that I will research in the future. I know that for example Rhodiola is said to be a MAOI, but I've read multiple reports that the MAOI of it is negligible, not to mention that it's a DHT inhibitor as well, which makes it not so useful for me, because my dopamine production is so low.

[Nate-2004]

You guys do realize that rhodiola only has a half life of 45 minutes right? That means any DHT inhibition is pretty minimal. I am still wondering if it shouldn't be taken more than once a day because of this.

[CWF1986]

It sounds like you have a doc you can go to or did at one time.  You can't get adderall or dex, got it.  Is methyphenidate possible to get as a prescription?  It works very well for adhd for me, but it has a great side effect profile for me.  But what about an activating antidepressant?  

 

In some small scale studies selegeline has shown effectiveness similar to methylphenidate.  Reboxetine is supposed to be very activating and as already mentioned wellbutrin.  Reboxetine is supposed to be better for treating adhd.  Desipramine is a tricyclic AD that's highly potent and selective for NRI and it's supposed to be very activating.  I don't have any personal experience with any of these except bupropion.  

 

I know here in the US you can find organizations that give relatively inexpensive healthcare including scripts for low and no income people.  It might be worth a look.  

 

Your issues sound like they go far beyond just optimization so it might be time to pull out the bigger guns.    

 

I take Adderall 20mg XR.  It was the theacrine in combination with adrafinil that produced effects closest to adderall that I've ever had.  Theacrine by itself helps some but nearly as much as the combo.  I found the effect of the combo was greater than the sum of it's parts.  

[nooguyz]

You guys do realize that rhodiola only has a half life of 45 minutes right? That means any DHT inhibition is pretty minimal. I am still wondering if it shouldn't be taken more than once a day because of this.

I actually didn't know that, but then it sounds even less like the kinda herb I should be taking anyway - I'm after long-term effects, at least a few hours (unless I can take it without food after), but preferably lasting whole day in the first place.

 

It sounds like you have a doc you can go to or did at one time.  You can't get adderall or dex, got it.  Is methyphenidate possible to get as a prescription?  It works very well for adhd for me, but it has a great side effect profile for me.  But what about an activating antidepressant?  

 

In some small scale studies selegeline has shown effectiveness similar to methylphenidate.  Reboxetine is supposed to be very activating and as already mentioned wellbutrin.  Reboxetine is supposed to be better for treating adhd.  Desipramine is a tricyclic AD that's highly potent and selective for NRI and it's supposed to be very activating.  I don't have any personal experience with any of these except bupropion.  

 

I know here in the US you can find organizations that give relatively inexpensive healthcare including scripts for low and no income people.  It might be worth a look.  

 

Your issues sound like they go far beyond just optimization so it might be time to pull out the bigger guns.    

 

I take Adderall 20mg XR.  It was the theacrine in combination with adrafinil that produced effects closest to adderall that I've ever had.  Theacrine by itself helps some but nearly as much as the combo.  I found the effect of the combo was greater than the sum of it's parts.  

I don't have a doc and never did, but I do have some experience with meds people shared for recreational purposes (except I pocketed them and used them when not intoxicated and in a much more controlled environment. Methylphenidate is perhaps possible - I'm still working on it, but I found a psych who was willing to do the assessment, and I know that Ritalin is prescribed here. However my underproduction for dopamine leads me to think that it won't have much of an effect, not to mention the potential side-effects. What side-effects does it give you?

 

I'm currently trying to get a list of medication that could be potentially prescribed if I do get the official diagnosis to determine if it's worth for me to even do that - it would cost me a month's rent to do that, and that's a serious hit on my financial situation, so I will see if they do prescribe any of the meds you mentioned including Adrafinil. I'm looking in the monthly costs for meds and the insurance coverage as well, as I actually failed to think of that before and just assumed that insurance should cover it because what the hell else is it for if not helping people function? That falls under my inability to understand how the world works, because many things just do not make sense to me, like the fact that the government is supposed to help you... But yeah, you're right, my issues go far beyond optimization, which is why I'm spending hours daily (when I can get myself to do it at all) researching supplements. Most supplements out there seem to be helpful for just adding a slight positive edge, but some seem to have much greater effect than others, and that's what I have to look into.

 

I'll post an update once I get the list of meds.

[Nate-2004]

I would choose Ritalin over Adderall if you're gonna go that route, or a Modafinil every 4 days might be even better.   

[nooguyz]

I would choose Ritalin over Adderall if you're gonna go that route, or a Modafinil every 4 days might be even better.   

That really made me think and actually not want Adderall and similar meds anymore, even though they help significantly.  I was wondering if a better route would be to combine Ritalin (or even better - simple potent MAOI herbs) with highly dopaminergic herbs instead, and just abandon the idea of ADHD meds. I also didn't think about the costs before, and I doubt it will be below 30eu/month. Also I confirmed that my insurance doesn't cover anything but the most basic healthcare, that is, if you have to be taken in an ambulance for an emergency. That's it. Nothing else. That's good in a way. I can stop feeling bad about not getting medication and focus on supplements. Hopefully they will be strong enough to fix my situation.

[Junipersun]

I have some experience with the issue. What works best for me is taking memantine in combination with tranylcypromine. Sometimes I add sublingual Agmatine to get a boost, but memantine alone works good in preventing the maoi poop out. I have also tried combining it with other maois - I think I got some added benefit from taking moclobemid, but that wasn't worth the extra cost. What works great is adding 9-me-bc, which is itself a maoi, but does a lot of other things to boost dopamine (which is where most of the undesireable tolerance comes from I think).

[Nate-2004]

Amphetamines and other stimulant drugs, MDMA, Coke, Meth, etc, can be neurotoxic in higher doses or with chronic use. I'd use them sparingly and use some antioxidant supplementation (example) when taking them.

[CWF1986]

Amphetamines and other stimulant drugs, MDMA, Coke, Meth, etc, can be neurotoxic in higher doses or with chronic use. I'd use them sparingly and use some antioxidant supplementation (example) when taking them.

 

There are risks with any drugs.  One also has to decide if it's an even greater risk to leave ADHD untreated.  I know there are risk to taking adderall, but the risks involved with ineffectively treated adhd are much greater.  Nothing by a long shot has helped as much as the adderall and I do need to take it nearly everyday.  

 

I do drink a lot of tea and have coffee in the morning so I'm thinking I'm getting my antioxidants there.  

[CWF1986]

I have some experience with the issue. What works best for me is taking memantine in combination with tranylcypromine. Sometimes I add sublingual Agmatine to get a boost, but memantine alone works good in preventing the maoi poop out. I have also tried combining it with other maois - I think I got some added benefit from taking moclobemid, but that wasn't worth the extra cost. What works great is adding 9-me-bc, which is itself a maoi, but does a lot of other things to boost dopamine (which is where most of the undesireable tolerance comes from I think).

 

MAOI's have always scared me off because of all the interactions between foods and other medications including some OTC's.  How was the adjustment for you?

[Junipersun]

 

I have some experience with the issue. What works best for me is taking memantine in combination with tranylcypromine. Sometimes I add sublingual Agmatine to get a boost, but memantine alone works good in preventing the maoi poop out. I have also tried combining it with other maois - I think I got some added benefit from taking moclobemid, but that wasn't worth the extra cost. What works great is adding 9-me-bc, which is itself a maoi, but does a lot of other things to boost dopamine (which is where most of the undesireable tolerance comes from I think).

 

MAOI's have always scared me off because of all the interactions between foods and other medications including some OTC's.  How was the adjustment for you?

 

 

Really no problem at all. The food thing is way overblown, that's what everybody tells you who is on non-selective, irreversible maois. There is a tiny percentage of people who do get food reactions, you just have to test it out if you belong to them. I don't even think about what I can eat or not anymore, as I have eaten all the "dangerous" stuff in high quantities without having any problem. I take care in relation to medication, which pretty much only concerns everything that fucks with serotonin. I can't take DXM for example if I have a bad cough. A badly treated depression or anxiety is WAY worse than the small adjustments you have to make because of taking maois.